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The Selective Inhibition of Delayed Potassium Currents in Nerve by Tetraethylammonium Ion
Open accessAbstract
The effect of tetraethylammonium ion (TEA) on the voltage clamp currents of nodes of Ranvier of frog myelinated nerve fibers is studied. The delayed K currents can be totally abolished by TEA without affecting the transient Na currents or the leakage current in any way. Both inward and outward currents disappear. In low TEA concentrations small K currents remain with normal time constants. The dose-response relationship suggests the formation of a complex between TEA and a receptor with a dissociation constant of 0.4 mM. Other symmetrical quaternary ammonium ions have very little effect. There is no competition between TEA and agents that affect the Na currents such as Xylocaine, tetrodotoxin, or Ca ions. The pharmacological data demonstrate that the Na, K, and leakage permeabilities are chemically independent, probably because their mechanisms occupy different sites on the nodal membrane. The data are gathered and analyzed by digital computer.
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Citations
Cited by
Diversity and ubiquity of K channels
Rudy, B. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90033-4 · Cited by 1,312
Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons
Armstrong, C. M. (1971) · The Journal of General Physiology · doi:10.1085/jgp.58.4.413 · Cited by 929
Meech, R. W., & Standen, N. B. (1975) · The Journal of Physiology · doi:10.1113/jphysiol.1975.sp011012 · Cited by 624
Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block
Wang, C., Takeuchi, K., Pinto, L. H., & Lamb, R. A. (1993) · Journal of Virology · doi:10.1128/jvi.67.9.5585-5594.1993 · Cited by 494
The aromatic binding site for tetraethylammonium ion on potassium channels
Heginbotham, L., & MacKinnon, R. (1992) · Neuron · doi:10.1016/0896-6273(92)90276-j · Cited by 451
Metadata
- Authors
- Hille, B.
- Venue
- The Journal of General Physiology
- Publisher
- Rockefeller University Press
- Published
- 1967-05-01
- Volume
- 50
- Issue
- 5
- Pages
- 1287-1302
- ISSN
- 0022-1295 (ISSN-L)
- 1540-7748
- OpenAlex
- W1964015678
- Cited by
- 490
- References
- 0
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Hille, B. (1967). The Selective Inhibition of Delayed Potassium Currents in Nerve by Tetraethylammonium Ion. The Journal of General Physiology. https://doi.org/10.1085/jgp.50.5.1287
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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