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Furosemide inhibition of chloride transport in human red blood cells.
Open accessAbstract
The chloride self-exchange flux across the human red cell membrane is rapidly and reversibly inhibited by 10(-4) M furosemide, a potent chloruretic agent. Furosemide reduces the chloride flux at all chloride concentrations and increases the cellular chloride concentration at which the flux is half-maximum. Kinetic analysis of the flux measurements made at several furosemide and chloride concentrations yields a pattern of mixed inhibition with a dissociation constant for the inhibitor-transport mechanism complex of 5 X 10(-5) M. From this pattern of inhibition and other observations, including that the percent inhibition is independent of pH (range 5.6-8.9), we conclude that the anionic form of furosemide interacts primarily with the chloride transport mechanism at a site separate from both the transport site and the halide-reactive modifier site.
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Citations
Cited by
Ioav Cabantchik, Z., Knauf, P. A., & Rothstein, A. (1978) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(78)90016-3 · Cited by 721
Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures
Kimelberg, H., Goderie, S., Higman, S., Pang, S., & Waniewski, R. (1990) · The Journal of Neuroscience · doi:10.1523/jneurosci.10-05-01583.1990 · Cited by 690
The Role of Chloride Transport in Postsynaptic Inhibition of Hippocampal Neurons
Misgeld, U., Deisz, R. A., Dodt, H. U., & Lux, H. D. (1986) · Science · doi:10.1126/science.2424084 · Cited by 398
Metadata
- Authors
- Brazy, P. C., & Gunn, R. B.
- Venue
- The Journal of general physiology
- Publisher
- Rockefeller University Press
- Published
- 1976-12-01
- Volume
- 68
- Issue
- 6
- Pages
- 583-599
- ISSN
- 0022-1295 (ISSN-L)
- 1540-7748
- OpenAlex
- W2116549996
- Cited by
- 233
- References
- 0
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Brazy, P. C., & Gunn, R. B. (1976). Furosemide inhibition of chloride transport in human red blood cells. The Journal of general physiology. https://doi.org/10.1085/jgp.68.6.583
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