The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
The Role of Chloride Transport in Postsynaptic Inhibition of Hippocampal Neurons
Abstract
Hippocampal inhibitory postsynaptic potentials are depolarizing in granule cells but hyperpolarizing in CA3 neurons because the reversal potentials and membrane potentials of these cells differ. Here the hippocampal slice preparation was used to investigate the role of chloride transport in these inhibitory responses. In both cell types, increasing the intracellular chloride concentration by injection shifted the reversal potential of these responses in a positive direction, and blocking the outward transport of chloride with furosemide slowed their recovery from the injection. In addition, hyperpolarizing and depolarizing inhibitory responses and the hyperpolarizing and depolarizing responses to the inhibitory neurotransmitter γ-aminobutyric acid decreased in the presence of furosemide. These effects of furosemide suggest that the internal chloride activity of an individual hippocampal neuron is regulated by two transport processes, one that accumulates chloride and one that extrudes chloride.
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Cites
A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons
Hotson, J. R., & Prince, D. A. (1980) · Journal of Neurophysiology · doi:10.1152/jn.1980.43.2.409 · Cited by 569
Alger, B. E., & Nicoll, R. A. (1982) · The Journal of Physiology · doi:10.1113/jphysiol.1982.sp014256 · Cited by 518
Two different responses of hippocampal pyramidal cells to application of gamma‐amino butyric acid.
Andersen, P., Dingledine, R., Gjerstad, L., Langmoen, I. A., & Laursen, A. M. (1980) · The Journal of Physiology · doi:10.1113/jphysiol.1980.sp013363 · Cited by 482
Newberry, N. R., & Nicoll, R. A. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015107 · Cited by 329
GABA-mediated biphasic inhibitory responses in hippocampus
Alger, B. E., & Nicoll, R. A. (1979) · Nature · doi:10.1038/281315a0 · Cited by 326
Anomalous inward rectification in hippocampal neurons
Hotson, J. R., Prince, D. A., & Schwartzkroin, P. A. (1979) · Journal of Neurophysiology · doi:10.1152/jn.1979.42.3.889 · Cited by 247
Furosemide inhibition of chloride transport in human red blood cells.
Brazy, P. C., & Gunn, R. B. (1976) · The Journal of general physiology · doi:10.1085/jgp.68.6.583 · Cited by 233
Ammonium and Chloride Extrusion: Hyperpolarizing Synaptic Inhibition in Spinal Motoneurons
Lux, H. D. (1971) · Science · doi:10.1126/science.173.3996.555 · Cited by 200
Self-citationCellular factors influencing GABA response in hippocampal pyramidal cells
Wong, R. K., & Watkins, D. J. (1982) · Journal of Neurophysiology · doi:10.1152/jn.1982.48.4.938 · Cited by 175
Biphasic response of hippocampal pyramidal neurons to GABA
Thalmann, R. H., Peck, E. J., & Ayala, G. F. (1981) · Neuroscience Letters · doi:10.1016/0304-3940(81)90224-x · Cited by 112
Cited by
The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
Rivera, C., Voipio, J., Payne, J. A., Ruusuvuori, E., Lahtinen, H., Lamsa, K., Pirvola, U., Saarma, M., & Kaila, K. (1999) · Nature · doi:10.1038/16697 · Cited by 2,152
How brains make chaos in order to make sense of the world
Skarda, C. A., & Freeman, W. J. (1987) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00047336 · Cited by 2,097
Functional significance of cell volume regulatory mechanisms
LANG, F., BUSCH, G. L., RITTER, M., VÖLKL, H., WALDEGGER, S., GULBINS, E., & HÄUSSINGER, D. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.247 · Cited by 1,891
Giant synaptic potentials in immature rat CA3 hippocampal neurones.
Ben‐Ari, Y., Cherubini, E., Corradetti, R., & Gaiarsa, J. L. (1989) · The Journal of Physiology · doi:10.1113/jphysiol.1989.sp017762 · Cited by 1,317
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
Ben-Ari, Y., Gaiarsa, J.-L., Tyzio, R., & Khazipov, R. (2007) · Physiological Reviews · doi:10.1152/physrev.00017.2006 · Cited by 1,304
Metadata
- Authors
- Misgeld, U., Deisz, R. A., Dodt, H. U., & Lux, H. D.
- Venue
- Science
- Published
- 1986-06-13
- Volume
- 232
- Issue
- 4756
- Pages
- 1413-1415
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2071702312
- Cited by
- 398
- References
- 13
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Misgeld, U., Deisz, R. A., Dodt, H. U., & Lux, H. D. (1986). The Role of Chloride Transport in Postsynaptic Inhibition of Hippocampal Neurons. Science. https://doi.org/10.1126/science.2424084
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
