Inbreeding effects on fertility in humans: evidence for reproductive compensation.

Ober, Carole; Hyslop, Terry; Hauck, Walter W.

doi:10.1086/302198

Cited by 115Evolution and Genetic DynamicsGenetic Associations and EpidemiologyAnimal Behavior and Reproduction

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Inbreeding effects on fertility in humans: evidence for reproductive compensation.

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Ober, Carole, Hyslop, Terry, Hauck, Walter W.·1999·The American Journal of Human Genetics

DOI 10.1086/302198PMC PMC1377721

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Abstract

The effects of inbreeding on prereproductive mortality have been demonstrated in many natural populations, including humans. However, little is known about the effects in inbred individuals who survive to adulthood. We have investigated the effects of inbreeding on fertility among inbred adult Hutterites and demonstrate significantly reduced fecundity among the most inbred Hutterite women, as evidenced by longer interbirth intervals (P=.024) and longer intervals to a recognized pregnancy (P=.010) but not by increased rates of fetal loss (P>.50). These data suggest the presence of recessive alleles that adversely affect fecundity among the population. In contrast, completed family sizes do not differ among the more and the less-inbred Hutterite women who were born after 1920, suggesting that reproductive compensation is occurring among the more-inbred and less-fecund women. This recent reproductive strategy would facilitate the maintenance of recessive alleles and contribute to an overall decline in fertility in the population.

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Such a decrease would be lessened or nullified by reproductive compensation, as might occur in the Hutterites.
“Moreover, such a decrease would be lessened or nullified by reproductive compensation (Overall et al. 2002), as might occur in the Hutterites (Ober et al. 1999).”
From An Estimate of the Average Number of Recessive Lethal Mutations Carried by Humans (2015) · cites this paper as Ober et al. 1999

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Authors: Ober, C., Hyslop, T., & Hauck, W. W.
Affiliations: University of Chicago (US)
Thomas Jefferson University (US)
Corresponding author: Ober, Carole
ORCID: Ober, Carole
Hyslop, Terry
Venue: The American Journal of Human Genetics
Publisher: Elsevier BV
Published: 1999-01
Volume: 64
Issue: 1
Pages: 225-231
ISSN: 0002-9297 (ISSN-L)
DOI: 10.1086/302198
PMC: PMC1377721
OpenAlex: W2087819223
Cited by: 114
References: 26
Citations by year: 2025: 4 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 9 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 3 · 2013: 3 · 2012: 7
FWCI: 2.28
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 5313 d)
Locations: The American Journal of Human Genetics (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD021244, HD21244)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Animal Behavior and Reproduction
Keywords: inbreeding, fecundity, reproductive compensation, Hutterites, birth interval, time to pregnancy, fetal death, recessive alleles, family size, fertility decline, inbred populations
MeSH terms: Adult, Consanguinity, Female, Fertility, Humans, Male, Maternal Age, Parity, Pregnancy, Pregnancy Outcome, Survival Analysis

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Inbreeding effects on fertility in humans: evidence for reproductive compensation.

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