Ober, Carole

Genetic determinants of the gut microbiome in UK twins

Goodrich, J. K., Davenport, E. R., Beaumont, M., Jackson, M. A., Knight, R., Ober, C., Spector, T. D., Bell, J. T., Clark, A. G., & Ley, R. E. (2016) · Cell Host & Microbe

Gut microbiota and healthGenetic Associations and Epidemiology

Cited by 1,048

PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice

Baudat, F., Buard, J., Grey, C., Fledel-Alon, A., Ober, C., Przeworski, M., Coop, G., & de Massy, B. (2010) · Science

Genomics and Chromatin DynamicsChromosomal and Genetic Variations

Cited by 1,026

Innate Immunity and Asthma Risk in Amish and Hutterite Farm Children

Stein, M. M., Hrusch, C. L., Gozdz, J., Igartua, C., Pivniouk, V., Murray, S. E., Ledford, J. G., Marques dos Santos, M., Anderson, R. L., Metwali, N., et al. (2016) · New England Journal of Medicine

Asthma and respiratory diseasesAllergic Rhinitis and Sensitization

Cited by 939

A common variant associated with prostate cancer in European and African populations

Amundadottir, L. T., Sulem, P., Gudmundsson, J., Helgason, A., Baker, A., Agnarsson, B. A., Sigurdsson, A., Benediktsdottir, K. R., Cazier, J.-B., Sainz, J., et al. (2006) · Nature Genetics

Genetic Associations and EpidemiologyProstate Cancer Treatment and Research

Cited by 787

Sex-specific genetic architecture of human disease

Ober, C., Loisel, D. A., & Gilad, Y. (2008) · Nature Reviews Genetics

Sex and Gender in HealthcareGenetic Associations and Epidemiology

Cited by 787

Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes

Gudmundsson, J., Sulem, P., Steinthorsdottir, V., Bergthorsson, J. T., Thorleifsson, G., Manolescu, A., Rafnar, T., Gudbjartsson, D., Agnarsson, B. A., Baker, A., et al. (2007) · Nature Genetics

Genetic Associations and EpidemiologyProstate Cancer Treatment and Research

Cited by 723

The genetics of asthma and allergic disease: a 21st century perspective

Ober, C., & Yao, T. (2011) · Immunological Reviews

Asthma and respiratory diseasesIL-33, ST2, and ILC Pathways

Cited by 698

Seasonal Variation in Human Gut Microbiome Composition

Davenport, E. R., Mizrahi-Man, O., Michelini, K., Barreiro, L. B., Ober, C., & Gilad, Y. (2014) · PLoS ONE

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 314

Whole-genome association study identifies STK39 as a hypertension susceptibility gene

Wang, Y., O'Connell, J. R., McArdle, P. F., Wade, J. B., Dorff, S. E., Shah, S. J., Shi, X., Pan, L., Rampersaud, E., Shen, H., et al. (2009) · Proceedings of the National Academy of Sciences

Blood Pressure and Hypertension StudiesGenetic Associations and Epidemiology

Cited by 298

Estimating the human mutation rate using autozygosity in a founder population.

Campbell, C. D., Chong, J. X., Malig, M., Ko, A., Dumont, B. L., Han, L., Vives, L., O'Roak, B. J., Sudmant, P. H., Shendure, J., et al. (2012) · Nature Genetics

Genomics and Rare DiseasesEvolution and Genetic Dynamics

Cited by 215

TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone.

Huang, L., Szymanska, K., Jensen, V. L., Janecke, A. R., Innes, A. M., Davis, E. E., Frosk, P., Li, C., Willer, J. R., Chodirker, B. N., et al. (2011) · The American Journal of Human Genetics

Genetic and Kidney Cyst DiseasesCystic Fibrosis Research Advances

Cited by 194

DNA methylation in lung cells is associated with asthma endotypes and genetic risk

Nicodemus-Johnson, J., Myers, R. A., Sakabe, N. J., Sobreira, D. R., Hogarth, D. K., Naureckas, E. T., Sperling, A. I., Solway, J., White, S. R., Nobrega, M. A., et al. (2016) · JCI Insight

Asthma and respiratory diseasesEpigenetics and DNA Methylation

Cited by 180

Broad and narrow heritabilities of quantitative traits in a founder population

Abney, M., McPeek, M. S., & Ober, C. (2001) · The American Journal of Human Genetics

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 157

Sex-specific genetic architecture of whole blood serotonin levels

Weiss, L. A., Abney, M., Cook, E. H., & Ober, C. (2005) · The American Journal of Human Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 137

The effects of EBV transformation on gene expression levels and methylation profiles

Çalışkan, M., Cusanovich, D. A., Ober, C., & Gilad, Y. (2011) · Human Molecular Genetics

Epigenetics and DNA MethylationGenomics and Chromatin Dynamics

Cited by 134

Prenatal tobacco smoke exposure is associated with childhood DNA cpg methylation

Breton, C. V., Siegmund, K. D., Joubert, B. R., Wang, X., Qui, W., Carey, V., Nystad, W., Håberg, S. E., Ober, C., Nicolae, D., et al. (2014) · PLoS ONE

Epigenetics and DNA MethylationSmoking Behavior and Cessation

Cited by 119

Inbreeding effects on fertility in humans: evidence for reproductive compensation.

Ober, C., Hyslop, T., & Hauck, W. W. (1999) · The American Journal of Human Genetics

Evolution and Genetic DynamicsGenetic Associations and Epidemiology

Cited by 114

An Estimate of the Average Number of Recessive Lethal Mutations Carried by Humans

Gao, Z., Waggoner, D., Stephens, M., Ober, C., & Przeworski, M. (2015) · Genetics

Evolution and Genetic DynamicsGenomics and Rare Diseases

Cited by 109

Stress and bronchodilator response in children with asthma

Brehm, J. M., Ramratnam, S. K., Tse, S. M., Croteau-Chonka, D. C., Pino-Yanes, M., Rosas-Salazar, C., Litonjua, A. A., Raby, B. A., Boutaoui, N., Han, Y.-Y., et al. (2015) · American Journal of Respiratory and Critical Care Medicine

Asthma and respiratory diseasesChronic Obstructive Pulmonary Disease (COPD) Research

Cited by 106

A population-based study of autosomal-recessive disease-causing mutations in a founder population.

Chong, J. X., Ouwenga, R., Anderson, R. L., Waggoner, D. J., & Ober, C. (2012) · The American Journal of Human Genetics

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 55

Reducing mitochondrial reads in ATAC-seq using CRISPR/Cas9

Montefiori, L., Hernandez, L., Zhang, Z., Gilad, Y., Ober, C., Crawford, G., Nobrega, M., & Jo Sakabe, N. (2017) · Scientific Reports

Genomics and Chromatin DynamicsChromatin Remodeling and Cancer

Cited by 54

Evaluation of pediatric epigenetic clocks across multiple tissues

Fang, F., Zhou, L., Perng, W., Marsit, C. J., Knight, A. K., Cardenas, A., Aung, M. T., Hivert, M.-F., Aris, I. M., Goodrich, J. M., et al. (2023) · Clinical Epigenetics

Epigenetics and DNA MethylationBirth, Development, and Health

Cited by 33