The DOI matches its Crossref record.
Frequency of Symptomatic and Asymptomatic Herpes Simplex Virus Type 2 Reactivations among Human Immunodeficiency Virus–Infected Men
Open accessAbstract
Herpes simplex virus (HSV) infection is common in persons coinfected with human immunodeficiency virus (HIV). In a prospective study, daily viral cultures of the mouth, genitals, and rectum were collected from 68 HIV-positive and 13 HIV-negative men who have sex with men. Subjects completed a median of 57 days of follow-up. Anogenital HSV-2 cultures were positive on 405 (9.7%) of 4167 days for HIV-positive men and on 24 (3.1%) of 766 days for HIV-negative men. Most reactivations were perirectal and subclinical. Risk factors for increased HSV-2 shedding among HIV-positive men were low CD4 cell count (odds ratio, 2.5; 95% confidence interval, 1.2-5.4) and antibodies to both HSV-1 and HSV-2 versus HSV-2 only (odds ratio, 1.9; 95% confidence interval, 1.0-3.7). Three isolates obtained from 3 separate subjects were resistant to acyclovir. Thus, subclinical HSV-2 reactivation is an important opportunistic infection in persons with HIV infection. Further studies are necessaryto determine the impact of subclinical HSV-2 reactivation on the natural history of HIV infection.
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Cited by
Masur, P. B. H., Kaplan, J. E., & Holmes, K. K. (2002) · Annals of Internal Medicine · doi:10.7326/0003-4819-137-5_part_2-200209031-00002 · Cited by 567
Effect of Herpes Simplex Suppression on Incidence of HIV among Women in Tanzania
Watson-Jones, D., Weiss, H. A., Rusizoka, M., Changalucha, J., Baisley, K., Mugeye, K., Tanton, C., Ross, D., Everett, D., Clayton, T., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0800260 · Cited by 371
Ratnam, I., Chiu, C., Kandala, N. B., & Easterbrook, P. J. (2006) · Clinical Infectious Diseases · doi:10.1086/499356 · Cited by 355
Sobngwi‐Tambekou, J., Taljaard, D., Lissouba, P., Zarca, K., Puren, A., Lagarde, E., & Auvert, B. (2009) · The Journal of Infectious Diseases · doi:10.1086/597208 · Cited by 142
The etiology of infectious proctitis in men who have sex with men differs according to HIV status.
Bissessor, M., Fairley, C. K., Read, T., Denham, I., Bradshaw, C., & Chen, M. (2013) · Sexually Transmitted Diseases · doi:10.1097/olq.0000000000000022 · Cited by 65
Metadata
- Authors
- Schacker, T., Zeh, J., Hu, H., Hill, E., & Corey, L.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-12
- Volume
- 178
- Issue
- 6
- Pages
- 1616-1622
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2138483700
- Cited by
- 236
- References
- 0
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schacker, T., Zeh, J., Hu, H., Hill, E., & Corey, L. (1998). Frequency of Symptomatic and Asymptomatic Herpes Simplex Virus Type 2 Reactivations among Human Immunodeficiency Virus–Infected Men. The Journal of Infectious Diseases. https://doi.org/10.1086/314486
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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