Increased Nitric Oxide in Infective Gastroenteritis
Abstract
Nitric oxide (NO) production is increased in several inflammatory disorders, although the role of this gas is not clear. The purpose of this study was to determine whether luminal NO in the intestine is increased in infective gastroenteritis. Rectal gas was sampled in 17 patients with gastroenteritis and 10 healthy volunteers, with balloon catheters made of 100% silicone and analyzed for NO by chemiluminescence. Plasma nitrate and nitrite levels were determined by capillary electrophoresis. Rectal NO was (mean+/-SEM) 9441+/-3126 parts per billion (ppb) in the patients and 74+/-13 ppb in controls (P<.0001). There was no individual overlap. Plasma nitrite but not nitrate was significantly increased in patients compared with controls. These data indicate that luminal NO is greatly increased in gastroenteritis. The high levels of NO are easily measurable by rectal sampling, and measurement of luminal NO seems to be useful for evaluating local NO production in the gut in health and disease.
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Cites
Greatly increased luminal nitric oxide in ulcerative colitis
Lundberg, J. O. N., Lundberg, J. M., Alving, K., & Hellström, P. M. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90460-x · Cited by 266 · see citing works
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Biology of nitrogen oxides in the gastrointestinal tract
Lundberg, J. O., & Weitzberg, E. (2013) · Gut · doi:10.1136/gutjnl-2011-301649 · Cited by 200 · see citing works
Self-citationNitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care
Weitzberg, E., Hezel, M., Lundberg, J. O., & Warner, D. S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181fcf3cc · Cited by 145 · see citing works
Self-citationGastrointestinal nitric oxide generation in germ-free and conventional rats
Sobko, T., Reinders, C., Norin, E., Midtvedt, T., Gustafsson, L. E., & Lundberg, J. O. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00203.2004 · Cited by 75 · see citing works
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- Authors
- Herulf, M., Svenungsson, B., Lagergren, Å., Ljung, T., Morcos, E., Wiklund, N. P., Lundberg, J. O. N., & Weitzberg, E.
- Affiliations
- Karolinska Institutet (SE)
- Karolinska University Hospital (SE)
- Corresponding author
- Herulf, M.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-08
- Volume
- 180
- Issue
- 2
- Pages
- 542-545
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2169040393
- Cited by
- 48
- References
- 1
- Citations by year
- 2025: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2012: 1
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Tore Nilsons Stiftelse för Medicinsk Forskning
- Karolinska Institutet
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- nitric oxide, plasma nitrite, plasma nitrate, chemiluminescence
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Gastroenteritis, Gram-Negative Bacteria, Humans, Luminescent Measurements, Male, Middle Aged, Nitrates, Nitric Oxide, Nitrites, Rectum, Gram-Negative Bacterial Infections
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