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Cited by 266Inflammatory Bowel DiseaseNitric Oxide and Endothelin EffectsInflammatory mediators and NSAID effects

Greatly increased luminal nitric oxide in ulcerative colitis

Lundberg, J.O.N., Lundberg, J.M., Alving, K., Hellström, P.M.·1994·The Lancet
DOI 10.1016/s0140-6736(94)90460-x
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Abstract

A role for nitric oxide (NO) in ulcerative colitis has been suggested because mucosal NO synthase activity, measured by indirect assays, is increased in this disorder. We directly measured luminal NO in the colons of twelve controls and six patients with active ulcerative colitis. During colonoscopy, gas was aspirated from different parts of the colon and immediately analysed by a chemiluminescence technique. NO concentrations were more than 100 times higher in the patients than in the controls. Luminal NO is rapidly and easily measurable and may be used to monitor inflammatory bowel disease.

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Crossref · 10.1016/s0140-6736(94)90460-x

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  • In inflammatory bowel disease, massive blooms of pathogenic, nitrate-reducing Salmonella and Escherichia coli are seen in response to inflammation.

    “This shift is particularly notable in the context of inflammatory bowel disease, where massive blooms of pathogenic, nitrate-reducing Salmonella and Escherichia coli are seen in response to inflammation[333,334,338,339].”

    From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [339]

  • Salivary nitrate is reduced to nitrite by commensal anaerobic bacteria on the tongue.

    “which is then reduced to nitrite by commensal anaerobic bacteria on the tongue [22].”

    From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [22]

  • Chronic inflammation, including inflammatory bowel disease and Helicobacter pylori-induced gastritis, induces iNOS and generates large quantities of NO, forming nitrosating and oxidant species such as N2O3 and peroxynitrite, which might cause mutagenesis through deamination, nitration of DNA, or inhibition of the DNA repair system.

    “However, chronic inflammation, including inflammatory bowel disease and Helicobacter pylori-induced gastritis induce inducible NOS (iNOS) and generate large quantities of NO [22,146,147], forming nitrosating and oxidant species such as N2O3 and peroxynitrite, which might cause mutagenesis through deamination, nitration of DNA, or inhibition of the DNA repair system [148,149].”

    From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [22]

  • Acidic disproportionation of nitrite can lead to increased levels of NO.

    “Acidic disproportionation of nitrite can lead to increased levels of NO [84–86].”

    From Inorganic nitrite therapy: historical perspective and future directions (2011) · cites this paper as [86]

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Authors
Lundberg, J. O. N., Lundberg, J. M., Alving, K., & Hellström, P. M.
Affiliations
  • Karolinska Institutet (SE)
  • Karolinska University Hospital (SE)
Corresponding author
Lundberg, J.O.N.
ORCID
Venue
The Lancet
Publisher
Elsevier BV
Published
1994-12
Volume
344
Issue
8938
Pages
1673-1674
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/s0140-6736(94)90460-x
OpenAlex
W2054157046
Cited by
266
References
8
Citations by year
2026: 4 · 2025: 6 · 2024: 6 · 2023: 6 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 10 · 2015: 8 · 2014: 2 · 2013: 6 · 2012: 10
FWCI
5.68
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Keywords
nitric oxide, ulcerative colitis, nitric oxide synthase, inflammatory bowel disease, chemiluminescence measurement, colon, disease surveillance
MeSH terms
Adult, Aged, Colitis, Ulcerative, Colon, Colonoscopy, Humans, Luminescent Measurements, Middle Aged, Nitric Oxide

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