The DOI matches its Crossref record.
Immunogenicity and Impact on Nasopharyngeal Carriage of a Nonavalent Pneumococcal Conjugate Vaccine
Abstract
The safety, immunogenicity, and impact on carriage of a nonvalent pneumococcal vaccine given at ages 6, 10, and 14 weeks were examined in a double-blind, randomized, placebo-controlled trial in 500 infants in Soweto, South Africa. No serious local or systemic side effects were recorded. Significant antibody responses to all pneumococcal serotypes were observed 4 weeks after the third dose. Haemophilus influenzae type b polyribosylribitol phosphate (geometric mean titer, 11.62 microg/mL) and diphtheria (1.39 IU/mL) antibodies were significantly higher in children receiving pneumococcal conjugate, compared with placebo recipients (4.58 microgram/mL and 0.98 IU/mL, respectively). Nasopharyngeal carriage of vaccine serotypes decreased in vaccinees at age 9 months (18% vs. 36%), whereas carriage of nonvaccine serotypes increased (36% vs. 25%). Carriage of penicillin-resistant pneumococci (21% vs. 41%) and cotrimoxazole-resistant pneumococci (23% vs. 35%) were significantly reduced 9 months after vaccination, compared with controls.
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Citations
Cited by
Streptococcus pneumoniae colonisation: the key to pneumococcal disease
Bogaert, D., de Groot, R., & Hermans, P. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)00938-7 · Cited by 1,929
Efficacy of a Pneumococcal Conjugate Vaccine against Acute Otitis Media
Eskola, J., Kilpi, T., Palmu, A., Jokinen, J., Eerola, M., Haapakoski, J., Herva, E., Takala, A., Käyhty, H., Karma, P., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102083440602 · Cited by 1,455
Serotype replacement in disease after pneumococcal vaccination
Weinberger, D. M., Malley, R., & Lipsitch, M. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62225-8 · Cited by 1,020
A role for Streptococcus pneumoniae in virus-associated pneumonia
Madhi, S. A., Klugman, K. P., & The Vaccine Trialist Group (2004) · Nature Medicine · doi:10.1038/nm1077 · Cited by 565
Self-citationKaplan, S. L., Mason, E. O., Wald, E. R., Schutze, G. E., Bradley, J. S., Tan, T. Q., Hoffman, J. A., Givner, L. B., Yogev, R., & Barson, W. J. (2004) · Pediatrics · doi:10.1542/peds.113.3.443 · Cited by 417
Metadata
- Authors
- Mbelle, N., Huebner, R. E., Wasas, A. D., Kimura, A., Chang, I., & Klugman, K. P.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-10
- Volume
- 180
- Issue
- 4
- Pages
- 1171-1176
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2142965789
- Cited by
- 515
- References
- 0
- FWCI
- 31.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Immunogenicity and Impact on Nasopharyngeal Carriage of a Nonavalent Pneumococcal Conjugate Vaccine. https://app.cochat.ai/papers/10.1086/315009
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- Mbelle, N., Huebner, R. E., Wasas, A. D., Kimura, A., Chang, I., & Klugman, K. P. (1999). Immunogenicity and Impact on Nasopharyngeal Carriage of a Nonavalent Pneumococcal Conjugate Vaccine. The Journal of Infectious Diseases. https://doi.org/10.1086/315009
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
