The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Serotype replacement in disease after pneumococcal vaccination
Open accessAbstract
Vaccination with the protein-polysaccharide conjugate vaccine, PCV7, has significantly reduced the burden of pneumococcal disease in populations where it is in widespread use and has had an important public health benefit. This vaccine targets only 7 of the more than 92 pneumococcal serotypes, and there have been concerns that the non-vaccine serotypes (NVTs) could increase in prevalence and reduce the benefits of vaccination. Indeed, among asymptomatic carriers, the prevalence of NVTs has increased substantially, and as a result, there has been little or no net change in the carriage prevalence of the bacteria. In many populations, there has been an increase in pneumococcal disease caused by NVT, but in most cases this increase in NVT disease has been less than the increase in NVT carriage. In this article, we review the evidence for serotype replacement in carriage and disease and address the surveillance biases that might affect these findings. We then discuss possible reasons for the discrepancy between near-complete replacement in carriage and partial replacement for disease, and address the possibility that differences in invasiveness between vaccine serotypes and those causing replacement could contribute to this difference. We contend that the magnitude of serotype replacement in disease can be attributed, in part, to a combination of lower invasiveness of the replacing serotypes, biases in the pre-vaccine carriage data (unmasking), and biases in the disease surveillance systems that could underestimate the true amount of replacement. We conclude by discussing the potential for serotype replacement in disease in the future and the need for ongoing surveillance.
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Cites
Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children
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Association of Serotype with Risk of Death Due to Pneumococcal Pneumonia: A Meta‐Analysis
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Self-citation
Cited by
Respiratory risks from household air pollution in low and middle income countries
Gordon, S. B., Bruce, N. G., Grigg, J., Hibberd, P. L., Kurmi, O. P., Lam, K.-B. H., Mortimer, K., Asante, K. P., Balakrishnan, K., Balmes, J., et al. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70168-7 · Cited by 953
Waight, P. A., Andrews, N. J., Ladhani, S. N., Sheppard, C. L., Slack, M. P. E., & Miller, E. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)70044-7 · Cited by 589
Andrews, N. J., Waight, P. A., Burbidge, P., Pearce, E., Roalfe, L., Zancolli, M., Slack, M., Ladhani, S. N., Miller, E., & Goldblatt, D. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(14)70822-9 · Cited by 545
Feikin, D. R., Kagucia, E. W., Loo, J. D., Link-Gelles, R., Puhan, M. A., Cherian, T., Levine, O. S., Whitney, C. G., O’Brien, K. L., Moore, M. R., et al. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001517 · Cited by 470
Immunosenescence and pneumococcal disease: an imbalance in host-pathogen interactions.
Krone, C. L., van de Groep, K., Trzciński, K., Sanders, E. A. M., & Bogaert, D. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70165-6 · Cited by 134
Metadata
- Authors
- Weinberger, D. M., Malley, R., & Lipsitch, M.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 378
- Issue
- 9807
- Pages
- 1962-1973
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2150562212
- Cited by
- 1,020
- References
- 73
- FWCI
- 51.22
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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