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Cidofovir Protects Mice against Lethal Aerosol or Intranasal Cowpox Virus Challenge
Abstract
The efficacy of cidofovir for treatment of cowpox virus infection in BALB/c mice was investigated in an effort to evaluate new therapies for virulent orthopoxvirus infections of the respiratory tract in a small animal model. Exposure to 2(-5)x10(6) pfu of cowpox virus by aerosol or intranasally (inl) was lethal in 3- to 7-week-old animals. One inoculation of 100 mg/kg cidofovir on day 0, 2, or 4, with respect to aerosol infection, resulted in 90%-100% survival. Treatment on day 0 reduced peak pulmonary virus titers 10- to 100-fold, reduced the severity of viral pneumonitis, and prevented pulmonary hemorrhage. The same dose on day -6 to 2 protected 80%-100% of inl infected mice, whereas 1 inoculation on day -16 to -8 or day 3 to 6 was partially protective. Cidofovir delayed but did not prevent the death of inl infected mice with severe combined immunodeficiency. Treatment at the time of tail scarification with vaccinia virus did not block vaccination efficacy.
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Cited by
De Clercq, E. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.4.569-596.2003 · Cited by 369
Tscharke, D. C., Karupiah, G., Zhou, J., Palmore, T., Irvine, K. R., Haeryfar, S. M. M., Williams, S., Sidney, J., Sette, A., Bennink, J. R., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041912 · Cited by 299
Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections
Baker, R. O., Bray, M., & Huggins, J. W. (2003) · Antiviral Research · doi:10.1016/s0166-3542(02)00196-1 · Cited by 279
Self-citationProgress in the Discovery of Compounds Inhibiting Orthopoxviruses in Animal Models
Smee, D. F. (2008) · Antiviral Chemistry and Chemotherapy · doi:10.1177/095632020801900302 · Cited by 84
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Metadata
- Authors
- Bray, M., Martinez, M., Smee, D. F., Kefauver, D., Thompson, E., & Huggins, J. W.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-01
- Volume
- 181
- Issue
- 1
- Pages
- 10-19
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2101990110
- Cited by
- 216
- References
- 0
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bray, M., Martinez, M., Smee, D. F., Kefauver, D., Thompson, E., & Huggins, J. W. (2000). Cidofovir Protects Mice against Lethal Aerosol or Intranasal Cowpox Virus Challenge. The Journal of Infectious Diseases. https://doi.org/10.1086/315190
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