The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Association of Hepatitis C Virus–Specific CD8+T Cells with Viral Clearance in Acute Hepatitis C
Open accessAbstract
CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for acute hepatitis C is unclear. Our aim was to correlate the CD8+ T cell response with the outcome of infection. Eighteen patients with acute hepatitis C and 19 normal donors were studied. Hepatitis C virus (HCV)-specific CD8+ T cells were identified in the enzyme-linked immunospot assay by their interferon-gamma (IFN-gamma) production after specific stimulation. The highest numbers of IFN-gamma-producing HCV-specific CD8+ T cells were found in patients with acute hepatitis C and a self-limited course of disease during the first 6 months after onset of disease, but these numbers dropped thereafter to undetectable levels. The differences in responsiveness between patients with self-limited disease versus patients with a chronic course were statistically significant (P<.001). Our data show that the number of IFN-gamma-producing HCV-specific CD8+ T cells during the first 6 months after onset of disease is associated with eradication of the HCV infection.
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Cites
Phenotypic Analysis of Antigen-Specific T Lymphocytes
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T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Schoenberger, S. P., Toes, R. E. M., van der Voort, E. I. H., Offringa, R., & Melief, C. J. M. (1998) · Nature · doi:10.1038/31002 · Cited by 2,615
Help for cytotoxic-T-cell responses is mediated by CD40 signalling
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Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection
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Hepatitis B Virus Immunopathogenesis
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Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNA
Ogg, G. S., Jin, X., Bonhoeffer, S., Dunbar, P. R., Nowak, M. A., Monard, S., Segal, J. P., Cao, Y., Rowland-Jones, S. L., Cerundolo, V., et al. (1998) · Science · doi:10.1126/science.279.5359.2103 · Cited by 1,383
Analysis of a Successful Immune Response against Hepatitis C Virus
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Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection
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Gerlach, J. T., Diepolder, H. M., Jung, M., Gruener, N. H., Schraut, W. W., Zachoval, R., Hoffmann, R., Schirren, C. A., Santantonio, T., & Pape, G. R. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70353-7 · Cited by 714
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Cited by
Course and outcome of hepatitis C
Hoofnagle, J. H. (2002) · Hepatology · doi:10.1002/hep.1840360704 · Cited by 1,084
Memory CD8 + T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection
Shoukry, N. H., Grakoui, A., Houghton, M., Chien, D. Y., Ghrayeb, J., Reimann, K. A., & Walker, C. M. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030239 · Cited by 656
Orland, J. R., Wright, T. L., & Cooper, S. (2001) · Hepatology · doi:10.1053/jhep.2001.22112 · Cited by 196
Metadata
- Authors
- Grüner, N. H., Gerlach, T. J., Jung, M., Diepolder, H. M., Schirren, C. A., Schraut, W. W., Hoffmann, R., Zachoval, R., Santantonio, T., Cucchiarini, M., Cerny, A., & Pape, G. R.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-05
- Volume
- 181
- Issue
- 5
- Pages
- 1528-1536
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2164783799
- Cited by
- 365
- References
- 23
- FWCI
- 18.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Grüner, N. H., Gerlach, T. J., Jung, M., Diepolder, H. M., Schirren, C. A., Schraut, W. W., Hoffmann, R., Zachoval, R., Santantonio, T., Cucchiarini, M., Cerny, A., & Pape, G. R. (2000). Association of Hepatitis C Virus–Specific CD8+T Cells with Viral Clearance in Acute Hepatitis C. The Journal of Infectious Diseases. https://doi.org/10.1086/315450
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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