The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Interleukin‐1 Signaling Is Essential for Host Defense during Murine Pulmonary Tuberculosis
Open accessAbstract
Interleukin (IL)-1 signaling is required for the containment of infections with intracellular microorganisms, such as Listeria monocytogenes and Leishmania major. To determine the role of IL-1 in the host response to tuberculosis, we infected IL-1 type I receptor-deficient (IL-1R(-/-)) mice, in which IL-1 does not exert effects, with Mycobacterium tuberculosis. IL-1R(-/-) mice were more susceptible to pulmonary tuberculosis, as reflected by an increased mortality and an enhanced mycobacterial outgrowth in lungs and distant organs, which was associated with defective granuloma formation, containing fewer macrophages and fewer lymphocytes, whereas granulocytes were abundant. Lymphocytes were predominantly confined to perivascular areas, suggesting a defective migration of cells into inflamed tissue in the absence of IL-1 signaling. Impaired host defense in IL-1R(-/-) mice was further characterized by a decrease in the ability of splenocytes to produce interferon-gamma. Analysis of these data suggests that IL-1 plays an important role in the immune response to M. tuberculosis.
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Wilkinson, R. J., Patel, P., Llewelyn, M., Hirsch, C. S., Pasvol, G., Snounou, G., Davidson, R. N., & Toossi, Z. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.12.1863 · Cited by 295
Cited by
Genetic Dissection of Immunity to Mycobacteria: The Human Model
Casanova, J.-L., & Abel, L. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.081501.125851 · Cited by 991
Innate Immune Recognition of Mycobacterium tuberculosis
Kleinnijenhuis, J., Oosting, M., Joosten, L. A. B., Netea, M. G., & Van Crevel, R. (2011) · Clinical and Developmental Immunology · doi:10.1155/2011/405310 · Cited by 414
Fremond, C. M., Togbe, D., Doz, E., Rose, S., Vasseur, V., Maillet, I., Jacobs, M., Ryffel, B., & Quesniaux, V. F. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.1178 · Cited by 338
Inflammasome-independent regulation of IL-1-family cytokines
Netea, M. G., van de Veerdonk, F. L., van der Meer, J. W. M., Dinarello, C. A., & Joosten, L. A. B. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112306 · Cited by 326
Silva Miranda, M., Breiman, A., Allain, S., Deknuydt, F., & Altare, F. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/139127 · Cited by 318
Metadata
- Authors
- Juffermans, N. P., Florquin, S., Camoglio, L., Verbon, A., Kolk, A. H., Speelman, P., van Deventer, S. J. H., & van der Poll, T.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-09
- Volume
- 182
- Issue
- 3
- Pages
- 902-908
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2118033114
- Cited by
- 278
- References
- 1
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Juffermans, N. P., Florquin, S., Camoglio, L., Verbon, A., Kolk, A. H., Speelman, P., van Deventer, S. J. H., & van der Poll, T. (2000). Interleukin‐1 Signaling Is Essential for Host Defense during Murine Pulmonary Tuberculosis. The Journal of Infectious Diseases. https://doi.org/10.1086/315771
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