The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Innate Immune Recognition of Mycobacterium tuberculosis
Open accessAbstract
Tuberculosis (TB), caused by Mycobacterium tuberculosis(MTB), is a major health problem, with 10 million new cases diagnosed each year. Innate immunity plays an important role in the host defense against M. tuberculosis, and the first step in this process is recognition of MTB by cells of the innate immune system. Several classes of pattern recognition receptors (PPRs) are involved in the recognition of M. tuberculosis, including Toll-like receptors (TLRs), C-type lectin receptors (CLRs), and Nod-like receptors (NLRs). Among the TLR family, TLR2, TLR4, and TLR9 and their adaptor molecule MyD88 play the most prominent roles in the initiation of the immune response against tuberculosis. In addition to TLRs, other PRRs such as NOD2, Dectin-1, Mannose receptor, and DC-SIGN are also involved in the recognition of M. tuberculosis. Human epidemiological studies revealed that genetic variation in genes encoding for PRRs and downstream signaling products influence disease susceptibility, severity, and outcome. More insight into PRRs and the recognition of mycobacteria, combined with immunogenetic studies in TB patients, does not only lead to a better understanding of the pathogenesis of tuberculosis but also may contribute to the design of novel immunotherapeutic strategies.
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Cites
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Redelman-Sidi, G., Glickman, M. S., & Bochner, B. H. (2014) · Nature Reviews Urology · doi:10.1038/nrurol.2014.15 · Cited by 729
Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection
Bell, L. C. K., & Noursadeghi, M. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.128 · Cited by 389
Immunology of Mycobacterium tuberculosis Infections
Sia, J. K., & Rengarajan, J. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0022-2018 · Cited by 312
Simeone, R., Sayes, F., Song, O., Gröschel, M. I., Brodin, P., Brosch, R., & Majlessi, L. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004650 · Cited by 198
Bartens, M.-C., Gibson, A. J., Etherington, G. J., Di Palma, F., Holder, A., Werling, D., & Willcocks, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.764390 · Cited by 19
Metadata
- Authors
- Kleinnijenhuis, J., Oosting, M., Joosten, L. A. B., Netea, M. G., & Van Crevel, R.
- Venue
- Clinical and Developmental Immunology
- Publisher
- Hindawi Limited
- Published
- 2011
- Volume
- 2011
- Pages
- 1-12
- ISSN
- 1740-2522 (ISSN-L)
- 1740-2530
- OpenAlex
- W2156861171
- Cited by
- 414
- References
- 114
- FWCI
- 23.83
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kleinnijenhuis, J., Oosting, M., Joosten, L. A. B., Netea, M. G., & Van Crevel, R. (2011). Innate Immune Recognition of Mycobacterium tuberculosis. Clinical and Developmental Immunology. https://doi.org/10.1155/2011/405310
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
