The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Effects of Zinc Deficiency on Th1 and Th2 Cytokine Shifts
Abstract
Nutritional deficiency of zinc is widespread throughout developing countries, and zinc-deficient persons have increased susceptibility to a variety of pathogens. Zinc deficiency in an experimental human model caused an imbalance between Th1 and Th2 functions. Production of interferon-gamma and interleukin (IL)-2 (products of Th1) were decreased, whereas production of IL-4, IL-6, and IL-10 (products of Th2) were not affected during zinc deficiency. Zinc deficiency decreased natural killer cell lytic activity and percentage of precursors of cytolytic T cells. In HuT-78, a Th0 cell line, zinc deficiency decreased gene expression of thymidine kinase, delayed cell cycle, and decreased cell growth. Gene expression of IL-2 and IL-2 receptors (both alpha and beta) and binding of NF-kappaB to DNA were decreased by zinc deficiency in HuT-78. Decreased production of IL-2 in zinc deficiency may be due to decreased activation of NF-kappaB and subsequent decreased gene expression of IL-2 and IL-2 receptors.
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Zinc and immune function: the biological basis of altered resistance to infection
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Self-citationA TH1→TH2 switch is a critical step in the etiology of HIV infection
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Age, Thymopoiesis, and CD4+ T-Lymphocyte Regeneration after Intensive Chemotherapy
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Prasad, A. S., Halsted, J. A., & Nadimi, M. (1961) · The American Journal of Medicine · doi:10.1016/0002-9343(61)90137-1 · Cited by 791
Self-citationPrasad, A. S., Miale, A., FARID, Z., Sandstead, H. H., & Schulert, A. R. (1963) · PubMed · Cited by 586
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Bonaventura, P., Benedetti, G., Albarède, F., & Miossec, P. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2014.11.008 · Cited by 798
Zinc as a Gatekeeper of Immune Function
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Contribution of Selected Vitamins and Trace Elements to Immune Function
Wintergerst, E. S., Maggini, S., & Hornig, D. H. (2007) · Annals of Nutrition and Metabolism · doi:10.1159/000107673 · Cited by 692
Zinc and immunity: An essential interrelation
Maares, M., & Haase, H. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.03.022 · Cited by 346
Influence of Stress and Nutrition on Cattle Immunity
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Metadata
- Authors
- Prasad, A. S.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-09
- Volume
- 182
- Issue
- s1
- Pages
- S62-S68
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2132557486
- Cited by
- 396
- References
- 42
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- closed
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