The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Neurological Manifestations of Enterovirus 71 Infection in Children during an Outbreak of Hand, Foot, and Mouth Disease in Western Australia
Abstract
Enterovirus 71 (EV71) causes epidemics of hand, foot, and mouth disease associated with neurological complications in young children. We report an outbreak of EV71-associated neurological disease that occurred from February through September 1999 in Perth, Western Australia. Fourteen children with culture-proven, EV71-induced neurological disease were identified. Nine patients (64%) developed severe neurological disease; 4 of these patients developed long-term neurological sequelae. Neurological syndromes included aseptic meningitis, Guillain-Barré syndrome, acute transverse myelitis, acute cerebellar ataxia, opso-myoclonus syndrome, benign intracranial hypertension, and a febrile convulsion. Clinical and magnetic resonance imaging data indicated that immunopathology was a major factor in the pathogenesis of neurological disease in this outbreak. This finding is in contrast to reports of previous EV71 epidemics, in which virus-induced damage to gray matter was the most frequent cause of neurological disease.
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“Previous studies demonstrated EV71 can cause severe complications including aseptic meningitis, encephalitis and poliomyelitis-like paralysis [30]–[32]”
From Molecular Epidemiology of Human Enterovirus Associated with Aseptic Meningitis in Shandong Province, China, 2006–2012 (2014) · cites this paper as [30]
Citations
Cites
Bulletin of the World Health Organization
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Adams, R. D., & Victor, M. (1977) · Medical Entomology and Zoology · Cited by 1,718
An Epidemic of Enterovirus 71 Infection in Taiwan
Ho, M., Chen, E.-R., Hsu, K.-H., Twu, S., Chen, K., Tsai, S.-F., Wang, J., & Shih, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909233411301 · Cited by 1,165
Oberste, M. S., Maher, K., Kilpatrick, D. R., & Pallansch, M. A. (1999) · Journal of Virology · doi:10.1128/jvi.73.3.1941-1948.1999 · Cited by 854
An Apparently New Enterovirus Isolated from Patients with Disease of the Central Nervous System
Schmidt, N. J., Lennette, E. H., & Ho, H. H. (1974) · The Journal of Infectious Diseases · doi:10.1093/infdis/129.3.304 · Cited by 792
Neurologic Complications in Children with Enterovirus 71 Infection
Huang, C., Liu, C., Chang, Y., Chen, C., Wang, S., & Yeh, T. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909233411302 · Cited by 714
Fatal enterovirus 71 encephalomyelitis
Lum, L. C., Wong, K. T., Lam, S. K., Chua, K. B., Goh, A. Y. T., Lim, W., Ong, B. B., Paul, G. O., AbuBakar, S., & Lambert, M. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70155-6 · Cited by 318
Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria
Chumakov, M. P., Voroshilova, M. K., Shindarov, L., Lavrova, I. K., Грачева, Л. А., Koroleva, G. A., Vasilenko, S., Brodvarova, I., Nikolova, M., Gyurova, S., et al. (1979) · Archives of Virology · doi:10.1007/bf01317504 · Cited by 314
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Rotbart, H. A. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/20.4.971 · Cited by 312
Wang, S., Liu, C., Tseng, H., Wang, J., Huang, C., Chen, Y., Yang, Y., Lin, S., & Yeh, T. (1999) · Clinical Infectious Diseases · doi:10.1086/520149 · Cited by 303
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- Shindarov, 1979, Journal of hygiene, epidemiology, microbiology, and immunology, 23, 284
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Enterovirus infections in children
Chen, X., Guo, L., Lei, X., Zhao, L., Hei, M., Shen, J., Yin, J., Li, F., Deng, J., Liu, G., et al. (2026) · Pediatric Investigation · doi:10.1002/ped4.70081
Metadata
- Authors
- McMinn, P., Stratov, I., Nagarajan, L., & Davis, S.
- Affiliations
- Princess Margaret Hospital for Children (AU)
- Sir Charles Gairdner Hospital (AU)
- Corresponding author
- McMinn, P.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-01-15
- Volume
- 32
- Issue
- 2
- Pages
- 236-242
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2087572168
- Cited by
- 401
- References
- 25
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 11 · 2023: 9 · 2022: 14 · 2021: 10 · 2020: 7 · 2019: 15 · 2018: 16 · 2017: 23 · 2016: 22 · 2015: 35 · 2014: 39 · 2013: 33 · 2012: 27
- FWCI
- 8.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Outbreaks Research
- Keywords
- enterovirus 71, hand, foot and mouth disease, neurological complications, Guillain-Barré syndrome, aseptic meningitis, acute transverse myelitis, acute cerebellar ataxia, opsoclonus-myoclonus syndrome, idiopathic intracranial hypertension, febrile seizures, immunopathology, long-term neurological sequelae, outbreak, children
- MeSH terms
- Acute Disease, Antibodies, Viral, Australia, Cerebellar Ataxia, Child, Child, Preschool, Disease Outbreaks, Enterovirus Infections, Enterovirus, Female, Hand, Foot and Mouth Disease, Humans, Infant, Magnetic Resonance Imaging, Male, Meningitis, Aseptic, Myelitis, Transverse, Nervous System Diseases, Guillain-Barre Syndrome, Paraneoplastic Syndromes, Nervous System
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