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Probiotic Agents and Infectious Diseases: A Modern Perspective on a Traditional Therapy
Abstract
There is an increasing scientific and commercial interest in the use of beneficial microorganisms, or "probiotics," for the prevention and treatment of disease. The microorganisms most frequently used as probiotic agents are lactic-acid bacteria such as Lactobacillus rhamnosus GG (LGG), which has been extensively studied in recent literature. Multiple mechanisms of action have been postulated, including lactose digestion, production of antimicrobial agents, competition for space or nutrients, and immunomodulation. We have reviewed recent studies of probiotics for the treatment and control of infectious diseases. Studies of pediatric diarrhea show substantial evidence of clinical benefits from probiotic therapy in patients with viral gastroenteritis, and data on LGG treatment for Clostridium difficile diarrhea appear promising. However, data to support use of probiotics for prevention of traveler's diarrhea are more limited. New research suggests potential applications in vaccine development and prevention of sexually transmitted diseases. Further studies are needed to take full advantage of this traditional medical approach and to apply it to the infectious diseases of the new millennium.
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“As probiotics have been reported in several studies to restore the intestinal microbiota and gut barrier as well as hinder bacterial translocation, the therapeutic potential of probiotics in IBS has become of strong interest.10,11”
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Metadata
- Authors
- Alvarez-Olmos, M. I., & Oberhelman, R. A.
- Affiliations
- Tulane University (US)
- Corresponding author
- Oberhelman, R. A.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-06-01
- Volume
- 32
- Issue
- 11
- Pages
- 1567-1576
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2145683869
- Cited by
- 359
- References
- 104
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 14 · 2023: 7 · 2022: 9 · 2021: 24 · 2020: 10 · 2019: 11 · 2018: 18 · 2017: 11 · 2016: 11 · 2015: 14 · 2014: 13 · 2013: 25 · 2012: 21
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- probiotics, lactic acid bacteria, Lactobacillus rhamnosus GG, infectious diseases, childhood diarrhea, viral gastroenteritis, Clostridium difficile-associated diarrhea, traveler's diarrhea, immunomodulation, antimicrobial agents, vaccine development, sexually transmitted infections
- MeSH terms
- Animals, Antidiarrheals, Bifidobacterium, Biological Therapy, Communicable Diseases, Diarrhea, Gastric Mucosa, Humans, Intestinal Mucosa, Lactobacillus, Immunity, Mucosal, Probiotics
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