Cited by 359Probiotics and Fermented FoodsReproductive tract infections researchInfant Nutrition and Health

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Probiotic Agents and Infectious Diseases: A Modern Perspective on a Traditional Therapy

Alvarez-Olmos, M. I., Oberhelman, R. A.·2001·Clinical Infectious Diseases

DOI 10.1086/320518

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Abstract

There is an increasing scientific and commercial interest in the use of beneficial microorganisms, or "probiotics," for the prevention and treatment of disease. The microorganisms most frequently used as probiotic agents are lactic-acid bacteria such as Lactobacillus rhamnosus GG (LGG), which has been extensively studied in recent literature. Multiple mechanisms of action have been postulated, including lactose digestion, production of antimicrobial agents, competition for space or nutrients, and immunomodulation. We have reviewed recent studies of probiotics for the treatment and control of infectious diseases. Studies of pediatric diarrhea show substantial evidence of clinical benefits from probiotic therapy in patients with viral gastroenteritis, and data on LGG treatment for Clostridium difficile diarrhea appear promising. However, data to support use of probiotics for prevention of traveler's diarrhea are more limited. New research suggests potential applications in vaccine development and prevention of sexually transmitted diseases. Further studies are needed to take full advantage of this traditional medical approach and to apply it to the infectious diseases of the new millennium.

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MICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436
The American Journal of Gastroenterology
(2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.80003397.x · Cited by 2,202
Functional food science and gastrointestinal physiology and function
Salminen, S., Bouley, C., Boutron, M.-C., Cummings, J. H., Franck, A., Gibson, G. R., Isolauri, E., Moreau, M.-C., Roberfroid, M., & Rowland, I. (1998) · British Journal of Nutrition · doi:10.1079/bjn19980108 · Cited by 1,398
Analysis of Intestinal Flora Development in Breast-Fed and Formula-Fed Infants by Using Molecular Identification and Detection Methods
Harmsen, H. J. M., Wildeboer-Veloo, A. C. M., Raangs, G. C., Wagendorp, A. A., Klijn, N., BINDELS, J. G., & Welling, G. W. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001000-00019 · Cited by 1,326
Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus
Saavedra, J. M., Bauman, N. A., Perman, J. A., Yolken, R. H., Saavedra, J. M., Bauman, N. A., & Oung, I. (1994) · The Lancet · doi:10.1016/s0140-6736(94)91708-6 · Cited by 958
Overview of gut flora and probiotics
Holzapfel, W. H., Haberer, P., Snel, J., Schillinger, U., & Veld, J. H. J. H. I. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00044-0 · Cited by 884
Demonstration of safety of probiotics—A review
Salminen, S. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00128-7 · Cited by 884
Probiotics inhibit enteropathogenic E. coli adherence in vitro by inducing intestinal mucin gene expression
Mack, D. R., Michail, S. K., Wei, S. H., McDougall, L., & Hollingsworth, M. A. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.4.g941 · Cited by 839
Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis
Eschenbach, D. A., Davick, P., Williams, B. L., Klebanoff, S. J., Young-Smith, K., Critchlow, C. M., & Holmes, K. K. (1989) · Journal of Clinical Microbiology · doi:10.1128/jcm.27.2.251-256.1989 · Cited by 709
Enhancement of the Circulating Antibody Secreting Cell Response in Human Diarrhea by a Human Lactobacillus Strain
Kaila, M., Isolauri, E., Soppi, E. T., Virtanen, E., Laine, S., & Arvilommi, H. S. (1992) · Pediatric Research · doi:10.1203/00006450-199208000-00002 · Cited by 700
Probiotic Spectra of Lactic Acid Bacteria (LAB)
Naidu, A. S., Bidlack, W. R., & Clemens, R. (1999) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408699991279187 · Cited by 690
A human Lactobacillus strain (Lactobacillus casei sp strain GG) promotes recovery from acute diarrhea in children.
Isolauri, E., Juntunen, M., Rautanen, T., Sillanaukee, P., & Koivula, T. (1991) · PubMed · Cited by 684
Lactobacillus GG Administered in Oral Rehydration Solution to Children with Acute Diarrhea: A Multicenter European Trial
Guandalini, S., Pensabene, L., Zikri, M. A., Dias, J. A., Casali, L. G., Hoekstra, H., Kolaček, S., Massar, K., Mičetić‐Turk, D., Papadopoulou, A., et al. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001000-00018 · Cited by 659
HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis
Sewankambo, N. K., Gray, R. H., Wawer, M. J., Paxton, L. A., McNairn, D., Wabwire‐Mangen, F., Serwadda, D., Li, C., Kiwanuka, N., Hillier, S. L., et al. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01063-5 · Cited by 657
Antimicrobial substance from a human Lactobacillus strain
Silva, M., Jacobus, N. V., Deneke, C. F., & Gorbach, S. L. (1987) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.31.8.1231 · Cited by 558
Lactic Acid Bacteria in the Treatment of Acute Rotavirus Gastroenteritis
Majamaa, H., Isolauri, E., Saxelin, M., & Vesikari, T. (1995) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199504000-00012 · Cited by 551
Lactobacillus GG in the prevention of antibiotic-associated diarrhea in children
Vanderhoof, J. A., Whitney, D. B., Antonson, D. L., Hanner, T. L., Lupo, J. V., & Young, R. J. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70053-3 · Cited by 536
Taxonomy and physiology of probiotic lactic acid bacteria
Klein, G., Pack, A., Bonaparte, C., & Reuter, G. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00049-x · Cited by 505
Ecological control of the gastrointestinal tract. The role of probiotic flora
Bengmark, S. (1998) · Gut · doi:10.1136/gut.42.1.2 · Cited by 505
Lactic acid bacteria, their metabolic products and interference with microbial growth
Vandenbergh, P. A. (1993) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1993.tb00020.x · Cited by 475
SUCCESSFUL TREATMENT OF RELAPSING CLOSTRIDIUM DIFFICILE COLITIS WITH LACTOBACILLUS GG
Gorbach, S., Chang, T., & Goldin, B. R. (1987) · The Lancet · doi:10.1016/s0140-6736(87)92646-8 · Cited by 467
Oral tolerance.
Weiner, H. L. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.10762 · Cited by 455
Immune responses to dietary antigens: oral tolerance
Ströbel, S., & Mowat, A. M. (1998) · Immunology Today · doi:10.1016/s0167-5699(97)01239-5 · Cited by 454
Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake
Link‐Amster, H., Rochat, F., Saudan, K.-Y., Mignot, O., & Aeschlimann, J. (1994) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1994.tb00011.x · Cited by 432
Effects of probiotic bacteria on diarrhea, lipid metabolism, and carcinogenesis: a review of papers published between 1988 and 1998
de Roos, N. M., & Katan, M. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.405 · Cited by 430
Prophylactic Lactobacillus GGReduces Antibiotic-Associated Diarrhea in Children With Respiratory Infections: A Randomized Study
Arvola, T., Laiho, K., Torkkeli, S., Mykkänen, H. M., Salminen, S., Maunula, L., & Isolauri, E. (1999) · PEDIATRICS · doi:10.1542/peds.104.5.e64 · Cited by 426
Lactobacillus reuteri as a Therapeutic Agent in Acute Diarrhea in Young Children
Shornikova, A., Casas, I. A., Isolauri, E., Mykkänen, H. M., & Vesikari, T. (1997) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199704000-00008 · Cited by 394
Prevention of Travellers Diarrhoea by Lactobacillus GG
Oksanen, P. J., Salminen, S., Saxelin, M., Hämäläinen, P., Ihantola-Vormisto, A., Muurasniemi-Isoviita, L., Nikkari, S. T., Oksanen, T., Pörsti, I. H., Salminen, E. K., et al. (1990) · Annals of Medicine · doi:10.3109/07853899009147242 · Cited by 362
Human Colonic Microbiota: Ecology, Physiology and Metabolic Potential of Intestinal Bacteria
Macfarlane, G. T., & Macfarlane, S. (1997) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1997.11720708 · Cited by 349
Probiotics and prebiotics: can regulating the activities of intestinal bacteria benefit health?
Macfarlane, G. T., & Cummings, J. H. (1999) · BMJ · doi:10.1136/bmj.318.7189.999 · Cited by 347
Lactobacilli and Streptococci Induce Interleukin-12 (IL-12), IL-18, and Gamma Interferon Production in Human Peripheral Blood Mononuclear Cells
Miettinen, M., Matikainen, S., Vuopio‐Varkila, J., Pirhonen, J., Varkila, K., Kurimoto, M., & Julkunen, I. (1998) · Infection and Immunity · doi:10.1128/iai.66.12.6058-6062.1998 · Cited by 343
Prevention of beta-lactam-associated diarrhea by Saccharomyces boulardii compared with placebo.
McFarland, L. V., Surawicz, C. M., Greenberg, R. N., Elmer, G. W., Moyer, K. A., Melcher, S. A., Bowen, K., & Cox, J. L. (1995) · PubMed · Cited by 338
Probiotics and gastrointestinal health
Gorbach, S. L. (2000) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(99)00806-0 · Cited by 331
Effect ofLactobacillusGG Yoghurt in Prevention of Antibiotic Associated Diarrhoea
Siitonen, S., Vapaatalo, H., Salminen, S., Gordin, A., Saxelin, M., Wikberg, R., & Kirkkola, A.-L. (1990) · Annals of Medicine · doi:10.3109/07853899009147243 · Cited by 326
Biotherapeutic agents. A neglected modality for the treatment and prevention of selected intestinal and vaginal infections
Elmer, G. W. (1996) · JAMA · doi:10.1001/jama.275.11.870 · Cited by 326
Efficacy ofLactobacillus GGas a Diarrheal Preventive in Travelers
Hilton, E., Kolakowski, P., Singer, C., & Smith, M. A. M. (1997) · Journal of Travel Medicine · doi:10.1111/j.1708-8305.1997.tb00772.x · Cited by 322
Selection and design of probiotics
Klaenhammer, T. R. (1999) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(99)00076-8 · Cited by 317
Prevention of Helicobacter pylori infection by lactobacilli in a gnotobiotic murine model.
Kabir, A. M., Aiba, Y., Takagi, A., Kamiya, S., Miwa, T., & Koga, Y. (1997) · Gut · doi:10.1136/gut.41.1.49 · Cited by 308
Role of competition for nutrients in suppression of Clostridium difficile by the colonic microflora
Wilson, K. H., & Perini, F. (1988) · Infection and Immunity · doi:10.1128/iai.56.10.2610-2614.1988 · Cited by 297
HL-A ANTIGENS IN MYASTHENIA GRAVIS
Fritze, D., Herrmann, C., Naeim, F., Smith, G., & Walford, R. L. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91370-1 · Cited by 296
Oral Bacterial Therapy Reduces the Duration of Symptoms and of Viral Excretion in Children with Mild Diarrhea
Guarino, A., Canani, R. B., Spagnuolo, M. I., Albano, F., & Benedetto, L. D. (1997) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199711000-00005 · Cited by 294
Ingestion of Yogurt Containing Lactobacillus acidophilus as Prophylaxis for Candidal Vaginitis
Hilton, E., Isenberg, H. D., Alperstein, P., France, K., & Borenstein, M. T. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-5-353 · Cited by 288
Viable versus inactivated lactobacillus strain GG in acute rotavirus diarrhoea.
Kaila, M., Isolauri, E., Saxelin, M., Arvilommi, H. S., & Vesikari, T. (1995) · Archives of Disease in Childhood · doi:10.1136/adc.72.1.51 · Cited by 287
A placebo-controlled trial of Lactobacillus GG to prevent diarrhea in undernourished Peruvian children
Oberhelman, R. A., Gilman, R. H., Sheen, P., Taylor, D. N., Black, R. E., Cabrera, L. Z., Lescano, A. G., Meza, R. A., & Madico, G. E. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70366-5 · Cited by 284
Self-citation
Treatment of Recurrent Clostridium difficile Colitis With Lactobacillus GG
Biller, J. A., Katz, A. J., Flores, A. F., Buie, T. M., & Gorbach, S. L. (1995) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199508000-00016 · Cited by 283
Saccharomyces boulardii inhibits Clostridium difficile toxin A binding and enterotoxicity in rat ileum
Pothoulakis, C., Kelly, C. P., Joshi, M. A., Gao, N., O'Keane, C. J., Castagliuolo, I., & LaMont, J. T. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90280-p · Cited by 280
Prevention and Treatment of Traveler's Diarrhea
Wood, A. J. J., DuPont, H. L., & Ericsson, C. D. (1993) · New England Journal of Medicine · doi:10.1056/nejm199306243282507 · Cited by 274
Heat-killed Lactobacillus plantarum L-137 suppresses naturally fed antigen–specific IgE production by stimulation of IL-12 production in mice
Murosaki, S., Yamamoto, Y., Ito, K., Inokuchi, T., Kusaka, H., Ikeda, H., & Yoshikai, Y. (1998) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(98)70055-7 · Cited by 273
Viricidal effect of Lactobacillus acidophilus on human immunodeficiency virus type 1: possible role in heterosexual transmission.
Klebanoff, S. J., & Coombs, R. W. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.1.289 · Cited by 273
Effect of perorally administered lactobacilli on macrophage activation in mice
Perdigón, G., de Macias, M. E. N., Alvarez, S., Oliver, G. D., & Holgado, A. A. D. R. (1986) · Infection and Immunity · doi:10.1128/iai.53.2.404-410.1986 · Cited by 265
Is there a role for lactobacilli in prevention of urogenital and intestinal infections?
Reid, G., Bruce, A. W., McGroarty, J. A., Cheng, K. J., & Costerton, J. W. (1990) · Clinical Microbiology Reviews · doi:10.1128/cmr.3.4.335 · Cited by 247
Lactobacilli from human gastrointestinal mucosa are strong stimulators of IL-12 production
Hessle, C. C., Hanson, L. A., & Wold, A. E. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.00885.x · Cited by 230
Prevention and Treatment of Traveler's Diarrhea
Cesarman, G., Cesarman, E., & Lagos, G. (1993) · New England Journal of Medicine · doi:10.1056/nejm199311183292122 · Cited by 206
YOGHURT WITH BIFIDOBACTERIUM LONGUM REDUCES ERYTHROMYCIN-INDUCED GASTROINTESTINAL EFFECTS
Colombel, J., Cortot, A., Neut, C., & Romond, C. (1987) · The Lancet · doi:10.1016/s0140-6736(87)93078-9 · Cited by 197
Biotherapeutic Agents
Elmer, G. W. (1996) · JAMA · doi:10.1001/jama.1996.03530350052034 · Cited by 196
Lactobacillus GG promotes recovery from acute nonbloody diarrhea in Pakistan
RAZA, S., Graham, S. M., Allen, S. J., Sultana, S., Cuevas, L. E., & Hart, C. A. (1995) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-199502000-00005 · Cited by 195
Lactobacilli and Bacteremia in Southern Finland, 1989-1992
Saxelin, M., Chuang, N.-H., Chassy, B., Rautelin, H., Makela, P. H., Salminen, S., & Gorbach, S. L. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.3.564 · Cited by 186
The Annals of Pharmacotherapy
(1996) · Annals of Pharmacotherapy · doi:10.1177/106002809603000125 · Cited by 185
Saccharomyces boulardii Enhances Rat Intestinal Enzyme Expression by Endoluminal Release of Polyamines
Buts, J., Keyser, N. D., & Raedemaeker, L. D. (1994) · Pediatric Research · doi:10.1203/00006450-199410000-00019 · Cited by 175
Use of Probiotics in Childhood Gastrointestinal Disorders
Vanderhoof, J. A., & Young, R. J. (1998) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199809000-00011 · Cited by 168
A trial in the Karelian Republic of oral rehydration and Lactobacillus GG for treatment of acute diarrhoea
Shornikova, A., Isolauri, E., Burkanova, L., Lukovnikova, S., & Vesikari, T. (1997) · Acta Paediatrica · doi:10.1111/j.1651-2227.1997.tb08913.x · Cited by 164
Saccharomyces boulardii: A Review of an Innovative Bio therapeutic Agent
McFarland, L. V., & Bernasconi, P. (1993) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v6i4.8126 · Cited by 153
The Vaginal Microbial Ecosystem and Resistance to HIV
Hillier, S. L. (1998) · AIDS Research and Human Retroviruses · doi:10.1177/088922299801401s05 · Cited by 150
THE EFFECT OF SUPPLEMENTATION WITH MILK FERMENTED BY LACTOBACILLUS CASEI (STRAIN DN‐114 001) ON ACUTE DIARRHOEA IN CHILDREN ATTENDING DAY CARE CENTRES
Pedone, C., Bernabeu, A. S., Postaire, E., Bouley, C., & Reinert, P. (1999) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.1999.tb11698.x · Cited by 142
A Double-Blind, Placebo-Controlled Study of the Efficacy of Lactinex in the Prophylaxis of Amoxicillin-Induced Diarrhea
Tankanow, R. M., Ross, M. B., Ertel, I. J., Dickinson, D. G., McCormick, L. S., & GARFINKEL, J. (1990) · DICP · doi:10.1177/106002809002400408 · Cited by 140
Healthy gut microflora and allergy: factors influencing development of the microbiota
Kirjavainen, P. V., & Gibson, G. R. (1999) · Annals of Medicine · doi:10.3109/07853899908995892 · Cited by 138
Lactobacillus GG and acute diarrhoea in young children in the tropics
Pant, A. (1996) · Journal of Tropical Pediatrics · doi:10.1093/tropej/42.3.162 · Cited by 138
Saccharomyces boulardii'. A Review of an Innovative Biotherapeutic Agent
McFarland, L. V., & Bernasconi, P. (1993) · Microbial Ecology in Health and Disease · doi:10.3109/08910609309141323 · Cited by 133
Probiotic use of lactobacilli in the human female urogenital tract
McGroarty, J. A. (1993) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1993.tb00337.x · Cited by 132
Clinical Evaluation of the Addition of Lyophilized, Heat-Killed Lactobacillus acidophilus LB to Oral Rehydration Therapy in the Treatment of Acute Diarrhea in Children
Simakachorn, N., Pichaipat, V., Rithipornpaisarn, P., Kongkaew, C., Tongpradit, P., & Varavithya, W. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001000-00020 · Cited by 130
Probiotics and infectious diarrhea
Saavedra, J. M. (2000) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(99)00811-4 · Cited by 128
Lactobacillus prophylaxis for diarrhea due to enterotoxigenic Escherichia coli
Clements, M. L., Levine, M. M., Black, R. E., Robins-Browne, R. M., Cisneros, L., Drusano, G. L., Lanata, C. F., & Saah, A. J. (1981) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.20.1.104 · Cited by 113
Clinical Evaluation of the Addition of Lyophilized, Heat-Killed Lactobacillus acidophilus LB to Oral Rehydration Therapy in the Treatment of Acute Diarrhea in Children
&NA; (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200002000-00030 · Cited by 104
Controlled trial of orally administered lactobacilli in acute infantile diarrhea
Pearce, J., & Hamilton, J. R. (1974) · The Journal of Pediatrics · doi:10.1016/s0022-3476(74)80618-9 · Cited by 103
Fungemia with Saccharomyces boulardii in a 1-Year-Old Girl with Protracted Diarrhea
Pletincx, M., Legein, J., & Vandenplas, Y. (1995) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199507000-00022 · Cited by 102
Lactobacillemia in liver transplant patients
Patel, R., Cockerill, F. R., Porayko, M. K., Osmon, D. R., Ilstrup, D. M., & Keating, M. R. (1994) · Clinical Infectious Diseases · doi:10.1093/clinids/18.2.207 · Cited by 100
Mucosal Immunity and Gastrointestinal Antigen Processing
Mayer, L. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001001-00002 · Cited by 99
Lactobacillus GG vaginal suppositories and vaginitis
Hilton, E., Rindos, P., & Isenberg, H. D. (1995) · Journal of Clinical Microbiology · doi:10.1128/jcm.33.5.1433-1433.1995 · Cited by 95
“Probiotic” remedies are not what they seem
Hamilton-Miller, J. M. T., Shah, S., & Smith, C. T. (1996) · BMJ · doi:10.1136/bmj.312.7022.55c · Cited by 92
SAFETY OF COMMERCIAL PRODUCTS WITH VIABLE LACTOBACILLUS STRAINS
Saxelin, M., Rautelin, H. I. K., Salminen, S., & Mäkelä, P. H. (1996) · Infectious Diseases in Clinical Practice · doi:10.1097/00019048-199606000-00011 · Cited by 90
Efficacy of SF 68 in the Treatment of Acute Diarrhea a Placebo-Controlled Trial
Buydens, P., & Debeuckelaere, S. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609051997 · Cited by 84
Microbes to Fight Microbes
Saavedra, J. M. (1995) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199508000-00001 · Cited by 82
Effects of feeding premature infants with Lactobacillus GG on gut fermentation.
Stansbridge, E. M., Walker, V., Hall, M. A., Smith, S. L., Millar, M. R., Bacon, C., & Chen, S. (1993) · Archives of Disease in Childhood · doi:10.1136/adc.69.5_spec_no.488 · Cited by 77
Immunopharmacological effects of Saccharomyces boulardii in healthy human volunteers
Caetano, J. A. M., Paramés, M. T., Babo, M. J., Santos, A., Ferreira, A. B., Freitas, A. A., Coelho, M. R. C., & Mateus, A. M. (1986) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(86)90106-2 · Cited by 76
Management of acute diarrhoea with low osmolarity oral rehydration solutions and Lactobacillus strain GG
Rautanen, T., Isolauri, E., Salo, E., & Vesikari, T. (1998) · Archives of Disease in Childhood · doi:10.1136/adc.79.2.157 · Cited by 73
Inhibitory activity of saccharomyces yeasts on the adhesion ofEntamoeba histolytica trophozoites to human erythrocytes in vitro
Rigothier, M. C., Maccario, J., & Gayral, P. (1994) · Parasitology Research · doi:10.1007/bf00932617 · Cited by 69
Normal Immune Responses to Ingested Foods
Husby, S. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200001001-00003 · Cited by 50
Vaginal Immunization with Recombinant Gram‐Positive Bacteria
Medaglini, D., Oggioni, M. R., & Pozzi, G. (1998) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.1998.tb00354.x · Cited by 50
Augmentation of host resistance to Listeria monocytogenes infection by Lactobacillus casei.
Nomoto, K., Miake, S., Hashimoto, S., Yokokura, T., Mutai, M., Yoshikai, Y., & Nomoto, K. (1985) · PubMed · Cited by 48
Bacterial competition as a means of preventing neonatal diarrhea in pigs
Davidson, J. N., & Hirsh, D. C. (1976) · Infection and Immunity · doi:10.1128/iai.13.6.1773-1774.1976 · Cited by 46
Erratum to “Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake” [FEMS Immunology and Medical Microbiology 10 (1994) 55–64]
Link‐Amster, H., Rochat, F., Saudan, K.-Y., Mignot, O., & Aeschlimann, J. (1995) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.1995.tb00203.x · Cited by 43
Enhancement of host resistance againstSalmonella typhimuriuminfection by a diet supplemented with yogurt
Simone, C. D., Tzantzoglou, S., Baldinelli, L., Difabio, S., Bianchi-Salvadori, B., Jirillo, E., & Vesely, R. (1988) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923978809041429 · Cited by 41
Immune-epithelial interactions in host defense.
Berin, M. C., McKay, D. M., & Perdue, M. H. (1999) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1999.60.16 · Cited by 40
Strategies for mucosal vaccine development.
Boyaka, P. N., Marinaro, M., VanCott, J. L., Takahashi, I., Fujihashi, K., Yamamoto, M. M., van Ginkel, F. W., Jackson, R. J., Kiyono, H., & McGhee, J. R. (1999) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1999.60.35 · Cited by 39
Ontogeny of Mucosal Immunity and Aging
Gleeson, M., & Cripps, A. W. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00011-2 · Cited by 28
Short Report: A Placebo-Controlled Study of Lactobacillus GG Colonization in One-to-Three-Year-Old Peruvian Children
Sheen, P., Oberhelman, R. A., Gilman, R. H., Cabrera, L., Verástegui, M., & Madico, G. E. (1995) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1995.52.389 · Cited by 25
Self-citation
Regulation of the mucosal immune response.
Ernst, P. B., Song, F., Klimpel, G. R., Haeberle, H. A., Bamford, K. B., Crowe, S. E., Ye, G., & Reyes, V. (1999) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1999.60.2 · Cited by 22
Induction by Lactobacillus casei of increase in macrophage colony-forming cells and serum colony-stimulating activity in mice.
Nanno, M., Ohwaki, M., & Mutai, M. (1986) · PubMed · Cited by 19
Prevention of diarrhea by the probiotic, Lactobacillus GG
DuPont, H. L. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70360-4 · Cited by 18
Regulation of Mucosal Immune Responses: Distinct Antigens and Antigen Presenting Cells
Mayer, L. (1997) · Journal of Clinical Immunology · doi:10.1023/a:1027382805727 · Cited by 7
Multiple antibiotic-resistant lactic acid bacteria preparation eliminated MRSA from the decubitus of a bed-ridden elderly patient.
Shigeru, K., yumiko, T., Hiroko, T., Shigehiko, M., Haruki, K., & Motoharu, K. (1997) · PubMed · Cited by 7
Oxford Handbook of Nursing Older People
(2009) · Oxford University Press eBooks · doi:10.1093/med/9780199213283.001.0001 · Cited by 6
Alternative repair pathways for UV-induced DNA damage
Yasui, A., & McCready, S. J. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199804)20:4

Research works printed but not linked: 14

1998, CHEMISTRY INDUSTRY, 8, 300
1999, 53, 67
1999, American Journal of Physiology -- Legacy Content, 276, G941
1997, 112, A1042
Nomoto, 1985, Journal of clinical & laboratory immunology, 17, 91
1993, 104, 1108
Nanno, 1986, Cancer Science, 77, 703
Isolauri, 1991, Pediatrics, 88, 90
1999, Pediatrics, 104, 1121
Hilton, 1992, Annals of Internal Medicine, 116, 353, 10.1059/0003-4819-116-5-353 · DOI
1998, AIDS research and human retroviruses, 14, S17
1996, INT CONF AIDS, 11, 383
1998, INT CONF AIDS, 12, 261
1997, Chinese medical journal, 110, 157

Sorted by citations

Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens
Servin, A. L. (2004) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2004.01.003 · Cited by 1,267
Antioxidant Properties of Probiotic Bacteria
Wang, Y., Wu, Y., Wang, Y., Xu, H., 梅小强, Yu, D., Wang, Y., & Li, W. (2017) · Nutrients · doi:10.3390/nu9050521 · Cited by 930
Lactobacillus Sepsis Associated With Probiotic Therapy
Land, M. H., Rouster-Stevens, K., Woods, C. R., Cannon, M. L., Cnota, J., & Shetty, A. K. (2005) · Pediatrics · doi:10.1542/peds.2004-2137 · Cited by 599
Survival of Probiotic Lactobacilli in Acidic Environments Is Enhanced in the Presence of Metabolizable Sugars
Corcoran, B. M., Stanton, C., Fitzgerald, G. F., & Ross, R. P. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.6.3060-3067.2005 · Cited by 547
An overview of the last advances in probiotic and prebiotic field
Saad, N., Delattre, C., Urdaci, M. C., Schmitter, J., & Bressollier, P. (2012) · LWT · doi:10.1016/j.lwt.2012.05.014 · Cited by 540

See all 359

Authors: Alvarez-Olmos, M. I., & Oberhelman, R. A.
Affiliations: Tulane University (US)
Corresponding author: Oberhelman, R. A.
ORCID: Alvarez-Olmos, M. I.
Oberhelman, R. A.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2001-06-01
Volume: 32
Issue: 11
Pages: 1567-1576
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1086/320518
OpenAlex: W2145683869
Cited by: 359
References: 104
Citations by year: 2026: 7 · 2025: 7 · 2024: 14 · 2023: 7 · 2022: 9 · 2021: 24 · 2020: 10 · 2019: 11 · 2018: 18 · 2017: 11 · 2016: 11 · 2015: 14 · 2014: 13 · 2013: 25 · 2012: 21
FWCI: 3.15
Type: journal article
Language: en
Open access: closed
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: probiotics, lactic acid bacteria, Lactobacillus rhamnosus GG, infectious diseases, childhood diarrhea, viral gastroenteritis, Clostridium difficile-associated diarrhea, traveler's diarrhea, immunomodulation, antimicrobial agents, vaccine development, sexually transmitted infections
MeSH terms: Animals, Antidiarrheals, Bifidobacterium, Biological Therapy, Communicable Diseases, Diarrhea, Gastric Mucosa, Humans, Intestinal Mucosa, Lactobacillus, Immunity, Mucosal, Probiotics

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Probiotic Agents and Infectious Diseases: A Modern Perspective on a Traditional Therapy

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