The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Type III Protein Secretion Is Associated with Death in Lower Respiratory and Systemic Pseudomonas aeruginosa Infections
Abstract
The ability of Pseudomonas aeruginosa to secrete specific toxins using the type III-mediated pathway has been reported. To determine the association of this phenotype with human illness, immunoblot analysis was used to detect expression of type III secretory proteins in P. aeruginosa isolates from respiratory tract or blood cultures of 108 consecutive patients. Relative risk of mortality was 6-fold greater with expression of the type III secretory proteins ExoS, ExoT, ExoU, or PcrV. Phenotype was independently correlated with toxicity in cellular and murine models. Prevalence of this phenotype was significantly higher in acutely infected patients than in chronically infected patients with cystic fibrosis. These results suggest that the type III protein secretion system is integral to increased P. aeruginosa virulence. A positive phenotype is a predictor of poor clinical outcome. In the future, such analyses may help distinguish potentially lethal infection from colonization and help determine appropriate therapy for critically ill patients.
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Cites
Type III Protein Secretion Systems in Bacterial Pathogens of Animals and Plants
Hueck, C. J. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.2.379-433.1998 · Cited by 2,394
Nosocomial infections in medical intensive care units in the United States
Richards, M. J., Edwards, J. R., Culver, D. H., & Gaynes, R. P. (1999) · Critical Care Medicine · doi:10.1097/00003246-199905000-00020 · Cited by 1,565
RE: “ESTIMABILITY AND ESTIMATION IN CASE-REFERENT STUDIES”
Halperin, M. (1977) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112409 · Cited by 1,542
Type III Secretion Machines: Bacterial Devices for Protein Delivery into Host Cells
Galán, J. E., & Collmer, A. (1999) · Science · doi:10.1126/science.284.5418.1322 · Cited by 1,319
Incidence, Risk, and Prognosis Factors of Nosocomial Pneumonia in Mechanically Ventilated Patients
Torres, A., Aznar, R., Gatell, J. M., Jiménez, P., González, J., Ferrer, A., Celis, R., & Rodriguez-Roisin, R. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/142.3.523 · Cited by 916
Nosocomial Infections in Pediatric Intensive Care Units in the United States
Richards, M. J., Edwards, J. R., Culver, D. H., Gaynes, R. P., & System, T. N. N. I. S. (1999) · Pediatrics · doi:10.1542/peds.103.4.e39 · Cited by 572
ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury
Finck‐Barbançon, V., Goranson, J., Zhu, L., Sawa, T., Wiener‐Kronish, J. P., Fleiszig, S. M. J., Wu, C., Mende‐Mueller, L., & Frank, D. W. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.4891851.x · Cited by 518
Self-citationFabregas, N., Ewig, S., Torres, A., El-Ebiary, M., Ramirez, J., de la Bellacasa, J. P., Bauer, T., & Cabello, H. (1999) · Thorax · doi:10.1136/thx.54.10.867 · Cited by 487
ExoY, an adenylate cyclase secreted by the Pseudomonas aeruginosa type III system
Yahr, T. L., Vallis, A. J., Hancock, M. K., Barbieri, J. T., & Frank, D. W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13899 · Cited by 464
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Cited by
The Epidemiology and Pathogenesis and Treatment of Pseudomonas aeruginosa Infections: An Update
Reynolds, D., & Kollef, M. (2021) · Drugs · doi:10.1007/s40265-021-01635-6 · Cited by 721
Analysis of quorum sensing-deficient clinical isolates of Pseudomonas aeruginosa
Schaber, J. A., Carty, N. L., McDonald, N. A., Graham, E. D., Cheluvappa, R., Griswold, J. A., & Hamood, A. N. (2004) · Journal of Medical Microbiology · doi:10.1099/jmm.0.45617-0 · Cited by 224
Metadata
- Authors
- Roy‐Burman, A., Savel, R. H., Racine, S., Swanson, B. L., Revadigar, N. S., Fujimoto, J., Sawa, T., Frank, D. W., & Wiener‐Kronish, J. P.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-06-15
- Volume
- 183
- Issue
- 12
- Pages
- 1767-1774
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2161014327
- Cited by
- 455
- References
- 25
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- Roy‐Burman, A., Savel, R. H., Racine, S., Swanson, B. L., Revadigar, N. S., Fujimoto, J., Sawa, T., Frank, D. W., & Wiener‐Kronish, J. P. (2001). Type III Protein Secretion Is Associated with Death in Lower Respiratory and Systemic Pseudomonas aeruginosa Infections. The Journal of Infectious Diseases. https://doi.org/10.1086/320737
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
