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Cited by 721

The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.

The Epidemiology and Pathogenesis and Treatment of Pseudomonas aeruginosa Infections: An Update

Open access
Reynolds, Dan, Kollef, Marin·2021·Drugs

Abstract

Pseudomonas aeruginosa is a Gram-negative bacterial pathogen that is a common cause of nosocomial infections, particularly pneumonia, infection in immunocompromised hosts, and in those with structural lung disease such as cystic fibrosis. Epidemiological studies have identified increasing trends of antimicrobial resistance, including multi-drug resistant (MDR) isolates in recent years. P. aeruginosa has several virulence mechanisms that increase its ability to cause severe infections, such as secreted toxins, quorum sensing and biofilm formation. Management of P. aeruginosa infections focuses on prevention when possible, obtaining cultures, and prompt initiation of antimicrobial therapy, occasionally with combination therapy depending on the clinical scenario to ensure activity against P. aeruginosa. Newer anti-pseudomonal antibiotics are available and are increasingly being used in the management of MDR P. aeruginosa.

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Metadata

Authors
Reynolds, D., & Kollef, M.
Venue
Drugs
Published
2021-11-07
Volume
81
Issue
18
Pages
2117-2131
ISSN
  • 0012-6667 (ISSN-L)
  • 1179-1950
OpenAlex
W3211805452
Cited by
721
References
131
FWCI
23.28
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: The Epidemiology and Pathogenesis and Treatment of Pseudomonas aeruginosa Infections: An Update. https://app.cochat.ai/papers/10.1007/s40265-021-01635-6
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Reynolds, D., & Kollef, M. (2021). The Epidemiology and Pathogenesis and Treatment of Pseudomonas aeruginosa Infections: An Update. Drugs. https://doi.org/10.1007/s40265-021-01635-6

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.