Association of human herpesvirus 6 reactivation with severe cytomegalovirus-associated disease in orthotopic liver transplant recipients

DesJardin, Jeffrey A.; Cho, Eunhui; Supran, Stacey; Gibbons, Laurie; Werner, Barbara G.; Snydman, David R.

doi:10.1086/323336

Cited by 74Cytomegalovirus and herpesvirus researchViral-associated cancers and disordersHerpesvirus Infections and Treatments

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Association of human herpesvirus 6 reactivation with severe cytomegalovirus-associated disease in orthotopic liver transplant recipients

DesJardin, Jeffrey A., Cho, Eunhui, Supran, Stacey, Gibbons, Laurie, Werner, Barbara G., Snydman, David R.·2001·Clinical Infectious Diseases

DOI 10.1086/323336

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Abstract

To explore the possible interaction between human herpesvirus 6 (HHV-6) and cytomegalovirus (CMV) in patients who have undergone organ transplantation, stored serum samples from 139 orthotopic liver transplant recipients were tested for HHV-6 immunoglobulin (Ig) G and IgM antibodies. HHV-6 reactivation occurred in 87 patients (62.6%) and was associated with CMV disease (P=.01), severe CMV-associated disease (P=.01), older age (P=.005), and use of muromonab-CD3 (Orthoclone; Orthobiotech) as treatment for rejection (P=.02). Trends for an association between HHV-6 reactivation and invasive fungal disease (P=.12), bacteremia (P=.10), and graft loss (P=.12) were seen. In a multivariate analysis of risk factors for severe CMV-associated disease, HHV-6 reactivation (relative risk [RR], 3.5; 95% confidence interval [CI], 1.2-10.2; P=.02), CMV donor-positive-recipient-negative match (RR, 5.7; 95% CI, 2.5-13.2; P<.001), and elevated serum creatinine level (P<.0001) were independent predictors. HHV-6 reactivation is associated with severe CMV-associated disease in liver transplant recipients.

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In the article by [5], only half of HHV-6 reactivations were detected by both an increase in IgG antibodies and presence of IgM antibodies, and 40% of the remaining patients had only a rise in IgG without IgM.
“In the article by [5], only half of the HHV-6 reactivations were detected by both an increase in IgG antibodies and presence of IgM antibodies. 40 % of the remaining patients had only a rise in IgG without IgM.”
From Meningoencephalitis in a background of inherited chromosomic integration of HHV-6 and CMV infection in an immunocompetent adult, which one is the culprit? (2025) · cites this paper as [5]

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Self-citation

Human Herpesvirus–6 Is Associated with Cytomegalovirus Reactivation in Liver Transplant Recipients
Humar, A., Malkan, G., Moussa, G., Greig, P. D., Levy, G. A., & Mazzulli, T. (2000) · The Journal of Infectious Diseases · doi:10.1086/315391 · Cited by 122
HHV-6 reactivation is often associated with CMV infection in liver transplant patients
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Interactions Between Cytomegalovirus, Human Herpesvirus‐6, and the Recurrence of Hepatitis C After Liver Transplantation
Humar, A., Kumar, D., Raboud, J., Caliendo, A. M., Moussa, G., Levy, G. A., & Mazzulli, T. (2002) · American Journal of Transplantation · doi:10.1034/j.1600-6143.2002.20511.x · Cited by 99
Seroconversion to Human Herpesvirus 6 following Liver Transplantation Is a Marker of Cytomegalovirus Disease
Dockrell, D. H., Prada, J., Jones, M. F., Patel, R., Badley, A. D., Harmsen, W. S., Ilstrup, D. M., Wiesner, R. H., Krom, R. A. F., Smith, T. F. A., et al. (1997) · The Journal of Infectious Diseases · doi:10.1086/514104 · Cited by 121
The Activation of Cytomegalovirus and Human Herpes Virus 6 After Liver Transplantation
Nasimfar, A., Sadeghi, E., Alborzi, A., Sepehrvand, N., Ziyaeyan, M., Jamalidoust, M., & Malek‐Hosseini, S. A. (2018) · Hepatitis Monthly · doi:10.5812/hepatmon.11987 · Cited by 8

Authors: DesJardin, J. A., Cho, E., Supran, S., Gibbons, L., Werner, B. G., & Snydman, D. R.
Affiliations: Tufts University (US)
Massachusetts Department of Public Health (US)
Corresponding author: Snydman, David R.
ORCID: Snydman, David R.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2001-10-15
Volume: 33
Issue: 8
Pages: 1358-1362
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1086/323336
OpenAlex: W2066104990
Cited by: 74
References: 12
Citations by year: 2026: 1 · 2025: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 1 · 2012: 4
FWCI: 4.07
Type: journal article
Language: en
Open access: closed
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Funders: CYTED Ciencia y Tecnología para el Desarrollo
National Institute of Allergy and Infectious Diseases (AI-07329, T32AI007329)
Topics: Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
Keywords: human herpesvirus 6, HHV-6 reactivation, cytomegalovirus disease, liver transplantation, co-infection, muromonab-CD3, graft rejection, serum creatinine, graft loss, invasive fungal infections, bacteremia, risk factors
MeSH terms: Adult, Antibodies, Viral, Cytomegalovirus Infections, Cytomegalovirus, Female, Herpesviridae Infections, Humans, Male, Middle Aged, Retrospective Studies, Virus Activation, Herpesvirus 6, Human, Liver Transplantation

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Association of human herpesvirus 6 reactivation with severe cytomegalovirus-associated disease in orthotopic liver transplant recipients

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