The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The Role of Toll‐like Receptor (TLR) 2 and TLR4 in the Host Defense against Disseminated Candidiasis
Open accessAbstract
Toll-like receptors (TLRs) represent the main class of pattern-recognition receptors involved in sensing pathogenic microorganisms. The aim of the present study was to assess the role of TLR4 in the defense against Candida albicans infection. The outgrowth of C. albicans was 10-fold higher in TLR4-defective C3H/HeJ mice, compared with that in control C3H/HeN mice (P<.05). Production of tumor necrosis factor (TNF) and interleukin (IL)-1alpha and IL-1beta by mouse macrophages in response to C. albicans stimulation was not affected by TLR4, and the candidacidal capacities of the neutrophils and macrophages of C3H/HeJ mice were normal. In contrast, production of the CXC chemokines KC and macrophage inhibitory protein-2 was 40%-60% lower by the macrophages of C3H/HeJ mice (P<.05), which resulted in a 40% decrease in neutrophil recruitment to the site of infection. Candida-induced TNF and IL-1beta production by human peripheral blood mononuclear cells was significantly inhibited by blocking anti-TLR2 antibodies in vitro. In conclusion, TLR4-defective C3H/HeJ mice are more susceptible to C. albicans infection, and this is associated with impaired chemokine expression and neutrophil recruitment.
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Cites
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 1×
“Indeed, studies performed during recent years have demonstrated that TLRs are the most important class of pattern-recognition receptors in mammals: TLR2 for peptidoglycans [4–6], lipoarabinomannan [7], and bacterial lipoproteins [8]; TLR4 for lipopolysaccharide (LPS) [9] and lipoteichoic acid [5]; TLR5 for flagellin […”
BackgroundPeptidoglycan- and Lipoteichoic Acid-induced Cell Activation Is Mediated by Toll-like Receptor 2
Schwandner, R., Dziarski, R., Wesche, H., Rothe, M., & Kirschning, C. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17406 · Cited by 1,704
Interaction of Candida albicans with Human Leukocytes and Serum
Lehrer, R. I., & Cline, M. J. (1969) · Journal of Bacteriology · doi:10.1128/jb.98.3.996-1004.1969 · Cited by 531
Lundqvist, H., & Dahlgren, C. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02189-2 · Cited by 221 · cited 1×
“Luminol-enhanced chemiluminescence of proteose-peptone–elicited PMNL was measured on a Victor 1420 multilabel counter (Wallac) at 20 C by use of white 96-well microplates (Costar), as described elsewhere [19].”
MethodCD14 and other recognition molecules for lipopolysaccharide: A review
Kielian, T. L., & Blecha, F. (1995) · Immunopharmacology · doi:10.1016/0162-3109(95)00003-c · Cited by 152
Cited by
Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793
Dectin-1: a signalling non-TLR pattern-recognition receptor
Brown, G. D. (2006) · Nature Reviews Immunology · doi:10.1038/nri1745 · Cited by 1,158
An integrated model of the recognition of Candida albicans by the innate immune system
Netea, M. G., Brown, G. D., Kullberg, B. J., & Gow, N. A. R. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1815 · Cited by 946
Self-citationCandida albicans morphogenesis and host defence: discriminating invasion from colonization
Gow, N. A. R., van de Veerdonk, F. L., Brown, A. J. P., & Netea, M. G. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2711 · Cited by 888
Self-citationBellocchio, S., Montagnoli, C., Bozza, S., Gaziano, R., Rossi, G., Mambula, S. S., Vecchi, A., Mantovani, A., Levitz, S. M., & Romani, L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.3059 · Cited by 515
Metadata
- Authors
- Netea, M. G., Van der Graaf, C. A. A., Vonk, A. G., Verschueren, I., Van der Meer, J. W. M., & Kullberg, B. J.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-05-15
- Volume
- 185
- Issue
- 10
- Pages
- 1483-1489
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2145564764
- Cited by
- 486
- References
- 5
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Netea, M. G., Van der Graaf, C. A. A., Vonk, A. G., Verschueren, I., Van der Meer, J. W. M., & Kullberg, B. J. (2002). The Role of Toll‐like Receptor (TLR) 2 and TLR4 in the Host Defense against Disseminated Candidiasis. The Journal of Infectious Diseases. https://doi.org/10.1086/340511
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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