The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Killing of Mycobacterium avium and Mycobacterium tuberculosis by a Mycobacteriophage Delivered by a Nonvirulent Mycobacterium: A Model for Phage Therapy of Intracellular Bacterial Pathogens
Abstract
Mycobacterium avium causes disseminated infection in patients with acquired immune deficiency syndrome. Mycobacterium tuberculosis is a pathogen associated with the deaths of millions of people worldwide annually. Effective therapeutic regimens exist that are limited by the emergence of drug resistance and the inability of antibiotics to kill dormant organisms. The present study describes a system using Mycobacterium smegmatis, an avirulent mycobacterium, to deliver the lytic phage TM4 where both M. avium and M. tuberculosis reside within macrophages. These results showed that treatment of M. avium-infected, as well as M. tuberculosis-infected, RAW 264.7 macrophages, with M. smegmatis transiently infected with TM4, resulted in a significant time- and titer-dependent reduction in the number of viable intracellular bacilli. In addition, the M. smegmatis vacuole harboring TM4 fuses with the M. avium vacuole in macrophages. These results suggest a potentially novel concept to kill intracellular pathogenic bacteria and warrant future development.
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Sturgill-Koszycki, S., Schlesinger, P. H., Chakraborty, P., Haddix, P. L., Collins, H. L., Fok, A. K., Allen, R. D., Gluck, S. L., Heuser, J., & Russell, D. G. (1994) · Science · doi:10.1126/science.8303277 · Cited by 1,302
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Population and evolutionary dynamics of phage therapy
Levin, B. R., & Bull, J. J. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro822 · Cited by 511
Experimental Phage Therapy against Staphylococcus aureus in Mice
Capparelli, R., Parlato, M., Borriello, G., Salvatore, P., & Iannelli, D. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01513-06 · Cited by 300
Phage therapy: Facts and fiction
Skurnik, M., & Strauch, E. (2006) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2005.09.002 · Cited by 296
Drulis-Kawa, Z., Majkowska-Skrobek, G., Maciejewska, B., Delattre, A.-S., & Lavigne, R. (2012) · Current Protein & Peptide Science · doi:10.2174/138920312804871193 · Cited by 261
Metadata
- Authors
- Broxmeyer, L., Sosnowska, D., Miltner, E., Chacón, O., Wagner, D., McGarvey, J., Barletta, R. G., & Bermudez, L. E.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-10-15
- Volume
- 186
- Issue
- 8
- Pages
- 1155-1160
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2120266933
- Cited by
- 160
- References
- 1
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Broxmeyer, L., Sosnowska, D., Miltner, E., Chacón, O., Wagner, D., McGarvey, J., Barletta, R. G., & Bermudez, L. E. (2002). Killing of Mycobacterium avium and Mycobacterium tuberculosis by a Mycobacteriophage Delivered by a Nonvirulent Mycobacterium: A Model for Phage Therapy of Intracellular Bacterial Pathogens. The Journal of Infectious Diseases. https://doi.org/10.1086/343812
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
