The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Experimental Phage Therapy against Staphylococcus aureus in Mice
Open accessAbstract
The present study describes a bacteriophage (M Sa ) active against Staphylococcus aureus , including methicillin-resistant staphylococcal strains. When inoculated into mice simultaneously with S. aureus A170 (10 8 CFU/mouse), phage (10 9 PFU) rescued 97% of the mice; when applied to nonlethal (5 × 10 6 CFU/mouse) 10-day infections, the phage also fully cleared the bacteria. The phage M Sa , delivered inside macrophages by S. aureus , kills the intracellular staphylococci in vivo and in vitro. The phage can also prevent abscess formation and reduce the bacterial load and weight of abscesses. These results suggest a potential use of the phage for the control of both local and systemic human S. aureus infections.
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Cites
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Genetic Analysis of a High-Level Vancomycin-Resistant Isolate of Staphylococcus aureus
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Cited by
Formulation, stabilisation and encapsulation of bacteriophage for phage therapy
Malik, D. J., Sokolov, I. J., Vinner, G. K., Mancuso, F., Cinquerrui, S., Vladisavljevic, G. T., Clokie, M. R. J., Garton, N. J., Stapley, A. G. F., & Kirpichnikova, A. (2017) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2017.05.014 · Cited by 594
Bacteriophage-encoded depolymerases: their diversity and biotechnological applications
Pires, D. P., Oliveira, H., Melo, L. D. R., Sillankorva, S., & Azeredo, J. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-7247-0 · Cited by 517
Phage Choice, Isolation, and Preparation for Phage Therapy
Gill, J., & Hyman, P. (2010) · Current Pharmaceutical Biotechnology · doi:10.2174/138920110790725311 · Cited by 441
Abuladze, T., Li, M., Menetrez, M. Y., Dean, T., Senecal, A., & Sulakvelidze, A. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.01465-08 · Cited by 353
Standardized bacteriophage purification for personalized phage therapy
Luong, T., Salabarria, A.-C., Edwards, R. A., & Roach, D. R. (2020) · Nature Protocols · doi:10.1038/s41596-020-0346-0 · Cited by 274
Metadata
- Authors
- Capparelli, R., Parlato, M., Borriello, G., Salvatore, P., & Iannelli, D.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2007-08
- Volume
- 51
- Issue
- 8
- Pages
- 2765-2773
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2121605092
- Cited by
- 300
- References
- 34
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
