Cited by 153Tuberculosis Research and EpidemiologyImmune responses and vaccinationsGenetic Associations and Epidemiology

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Interleukin‐10, Polymorphism in SLC11A1(formerly NRAMP1), and Susceptibility to Tuberculosis

Awomoyi, Agnes A., Marchant, Arnaud, Howson, Joanna M. M., McAdam, Keith P. W. J., Blackwell, Jenefer M., Newport, Melanie J.·2002·The Journal of Infectious Diseases

DOI 10.1086/345920

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Abstract

Host genetic factors are major determinants of susceptibility to tuberculosis, and an understanding of the molecular basis of this observation has major implications for the development of novel therapies and vaccines. Slc11a1 (formerly Nramp1), the first murine infection susceptibility locus identified, regulates early innate responses to intracellular pathogens. Variation in the human homologue SLC11A1 is associated with and linked to tuberculosis in genetically different populations. In a case-control study of 329 tuberculosis case patients and 324 control subjects, the association between allele 2 of a functional SLC11A1 polymorphism and tuberculosis has been reproduced. This variant is associated with higher lipopolysaccharide-induced production of the macrophage-deactivating cytokine interleukin-10. Furthermore, monocytes from persons who develop tuberculosis innately produce more interleukin-10 than do monocytes from healthy control subjects. These data therefore confirm the importance of SLC11A1 in tuberculosis susceptibility in humans and suggest that SLC11A1 influences tuberculosis susceptibility by regulation of interleukin-10.

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Authors: Awomoyi, A. A., Marchant, A., Howson, J. M. M., McAdam, K. P. W. J., Blackwell, J. M., & Newport, M. J.
Affiliations: MRC Unit the Gambia (GM)
John Radcliffe Hospital (GB)
Addenbrooke's Hospital (GB)
Corresponding author: Awomoyi, Agnes A.
ORCID: Marchant, Arnaud
Howson, Joanna M. M.
Blackwell, Jenefer M.
Newport, Melanie J.
Venue: The Journal of Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2002-12-15
Volume: 186
Issue: 12
Pages: 1808-1814
ISSN: 0022-1899 (ISSN-L)
1537-6613
DOI: 10.1086/345920
OpenAlex: W2171429463
Cited by: 153
References: 54
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 11 · 2012: 9
FWCI: 7.56
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Figshare (submittedVersion)
Sussex Research Online (University of Sussex) (submittedVersion)
Funders: Alexander and Margaret Stewart Trust
Wellcome Trust (065642)
Sir Halley Stewart Trust
Medical Research Council
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords: tuberculosis susceptibility, SLC11A1, NRAMP1, IL-10, genetic polymorphism, host genetic factors, monocytes, lipopolysaccharide, innate immunity, intracellular pathogens
MeSH terms: Natural Resistance-associated Macrophage Protein 1, Adult, Alleles, Gambia, Genotype, Humans, Immunity, Innate, Male, Middle Aged, Monocytes, Mycobacterium tuberculosis, Polymorphism, Genetic, Tuberculosis, Pulmonary, Case-Control Studies, Interleukin-10, Genetic Predisposition to Disease, Cation Transport Proteins

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Interleukin‐10, Polymorphism in SLC11A1(formerly NRAMP1), and Susceptibility to Tuberculosis

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