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Interleukin‐10, Polymorphism in SLC11A1(formerly NRAMP1), and Susceptibility to Tuberculosis
Abstract
Host genetic factors are major determinants of susceptibility to tuberculosis, and an understanding of the molecular basis of this observation has major implications for the development of novel therapies and vaccines. Slc11a1 (formerly Nramp1), the first murine infection susceptibility locus identified, regulates early innate responses to intracellular pathogens. Variation in the human homologue SLC11A1 is associated with and linked to tuberculosis in genetically different populations. In a case-control study of 329 tuberculosis case patients and 324 control subjects, the association between allele 2 of a functional SLC11A1 polymorphism and tuberculosis has been reproduced. This variant is associated with higher lipopolysaccharide-induced production of the macrophage-deactivating cytokine interleukin-10. Furthermore, monocytes from persons who develop tuberculosis innately produce more interleukin-10 than do monocytes from healthy control subjects. These data therefore confirm the importance of SLC11A1 in tuberculosis susceptibility in humans and suggest that SLC11A1 influences tuberculosis susceptibility by regulation of interleukin-10.
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“In both humans and mice, the function of NRAMP1 affects the balance between proinflammatory mediators such as TNF and IFN-γ and antiinflammatory ones such as IL-10 towards adequate production of the former (Awomoyi et al., 2002;Fritsche et al., 2003Fritsche et al., , 2008;;Kovarova et al., 2000).”
From Iron in infection and immunity (2020) · cites this paper as Awomoyi et al., 2002
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Metadata
- Authors
- Awomoyi, A. A., Marchant, A., Howson, J. M. M., McAdam, K. P. W. J., Blackwell, J. M., & Newport, M. J.
- Affiliations
- MRC Unit the Gambia (GM)
- John Radcliffe Hospital (GB)
- Addenbrooke's Hospital (GB)
- Corresponding author
- Awomoyi, Agnes A.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-12-15
- Volume
- 186
- Issue
- 12
- Pages
- 1808-1814
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2171429463
- Cited by
- 153
- References
- 54
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 11 · 2012: 9
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Figshare (submittedVersion)
- Sussex Research Online (University of Sussex) (submittedVersion)
- Funders
- Alexander and Margaret Stewart Trust
- Wellcome Trust (065642)
- Sir Halley Stewart Trust
- Medical Research Council
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- tuberculosis susceptibility, SLC11A1, NRAMP1, IL-10, genetic polymorphism, host genetic factors, monocytes, lipopolysaccharide, innate immunity, intracellular pathogens
- MeSH terms
- Natural Resistance-associated Macrophage Protein 1, Adult, Alleles, Gambia, Genotype, Humans, Immunity, Innate, Male, Middle Aged, Monocytes, Mycobacterium tuberculosis, Polymorphism, Genetic, Tuberculosis, Pulmonary, Case-Control Studies, Interleukin-10, Genetic Predisposition to Disease, Cation Transport Proteins
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