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A Potential Virulence Gene,hylEfm, Predominates in Enterococcus faecium of Clinical Origin
Abstract
An open reading frame (hyl(Efm)) with homologies to previously described hyaluronidase genes has been identified in nonstool isolates of Enterococcus faecium. E. faecium isolates (n=577) from diverse sources were screened for the presence of hyl(Efm) and esp(Efm), a putative virulence gene associated with epidemic E. faecium strains. The presence of esp(Efm) was roughly twice that of hyl(Efm), but both were found primarily in vancomycin-resistant E. faecium isolates in nonstool cultures obtained from patients hospitalized in the United States. These data suggest that specific E. faecium strains may be enriched in determinants that make them more likely to cause clinical infections. Differences in the prevalence of these strains may help explain variations in the clinical importance of multiresistant E. faecium across different continents.
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Cited by
Enterococci as probiotics and their implications in food safety
Franz, C. M. A. P., Huch, M., Abriouel, H., Holzapfel, W., & Gálvez, A. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.08.014 · Cited by 788
Vankerckhoven, V., Van Autgaerden, T., Vael, C., Lammens, C., Chapelle, S., Rossi, R., Jabes, D., & Goossens, H. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.10.4473-4479.2004 · Cited by 594
Self-citationThe Genus Enterococcus: Between Probiotic Potential and Safety Concerns—An Update
Hanchi, H., Mottawea, W., Sebei, K., & Hammami, R. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01791 · Cited by 569
Fiore, E., Van Tyne, D., & Gilmore, M. S. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0053-2018 · Cited by 503
Ahmed, M. O., & Baptiste, K. E. (2018) · Microbial Drug Resistance · doi:10.1089/mdr.2017.0147 · Cited by 438
Metadata
- Authors
- Rice, L. B., Carias, L., Rudin, S., Vael, C., Goossens, H., Konstabel, C., Klare, I., Nallapareddy, S. R., Huang, W., & Murray, B. E.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-02
- Volume
- 187
- Issue
- 3
- Pages
- 508-512
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2116673555
- Cited by
- 261
- References
- 0
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Potential Virulence Gene,hylEfm, Predominates in Enterococcus faecium of Clinical Origin. https://app.cochat.ai/papers/10.1086/367711
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- Rice, L. B., Carias, L., Rudin, S., Vael, C., Goossens, H., Konstabel, C., Klare, I., Nallapareddy, S. R., Huang, W., & Murray, B. E. (2003). A Potential Virulence Gene,hylEfm, Predominates in Enterococcus faecium of Clinical Origin. The Journal of Infectious Diseases. https://doi.org/10.1086/367711
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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