The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Role of Neuraminidase in Lethal Synergism between Influenza Virus and Streptococcus pneumoniae
Open accessAbstract
A lethal synergism exists between influenza virus and Streptococcus pneumoniae, accounting for excess mortality during influenza epidemics.Using a model of viral-bacterial synergism, we assessed the role that the influenza virus neuraminidase (NA) has in priming mice for pneumococcal infection.Administration of the selective NA inhibitor oseltamivir improved survival, independent of viral replication and morbidity from influenza.Both pathologic examination of the lungs and live imaging of pneumonic lesions, using a bioluminescent pneumococcus, suggested that the effect of NA inhibition was to limit the extent of pneumococcal pneumonia during early infection.Adherence assays and immunohistochemical staining for sialic acids in lungs from infected mice demonstrated that the influenza virus NA potentiates development of pneumonia by stripping sialic acid from the lung, thus exposing receptors for pneumococcal adherence.Selective NA inhibitors may be useful clinically to interrupt this novel mechanism of synergism and to prevent excess mortality from secondary bacterial pneumonia.A synergism exists between influenza virus and bacterial pathogens, accounting for excess mortality during influenza epidemics [1-3].Combined, influenza and pneumonia rank as the sixth leading cause of death worldwide and as the leading infectious cause of death [4].The impact of interventions against influenza and Strepto-
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Oral oseltamivir treatment of influenza in children
WHITLEY, R. J., HAYDEN, F. G., REISINGER, K. S., YOUNG, N., DUTKOWSKI, R., IPE, D., MILLS, R. G., & WARD, P. (2001) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-200102000-00002 · Cited by 711
Options for the control of influenza III
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Hayden, F. G., Treanor, J. J., Fritz, R. S., Lobo, M., Betts, R. F., Miller, M., Kinnersley, N., Mills, R. G., Ward, P., & Straus, S. E. (1999) · JAMA · doi:10.1001/jama.282.13.1240 · Cited by 550
Use of the Selective Oral Neuraminidase Inhibitor Oseltamivir to Prevent Influenza
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The Impact of Influenza Epidemics on Hospitalizations
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Pneumococcal Virulence Factors: Structure and Function
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Cited by
Insights into the Interaction between Influenza Virus and Pneumococcus
McCullers, J. A. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00058-05 · Cited by 846
Self-citationThe co-pathogenesis of influenza viruses with bacteria in the lung.
McCullers, J. A. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3231 · Cited by 722
Self-citationViral and Bacterial Interactions in the Upper Respiratory Tract
Bosch, A. A. T. M., Biesbroek, G., Trzcinski, K., Sanders, E. A. M., & Bogaert, D. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003057 · Cited by 651
Sun, K., & Metzger, D. W. (2008) · Nature Medicine · doi:10.1038/nm1765 · Cited by 587
Secondary bacterial infections associated with influenza pandemics
Morris, D. E., Cleary, D. W., & Clarke, S. C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01041 · Cited by 576
Metadata
- Authors
- McCullers, J. A., & Bartmess, K. C.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-03-15
- Volume
- 187
- Issue
- 6
- Pages
- 1000-1009
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2128374872
- Cited by
- 386
- References
- 43
- FWCI
- 9.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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