The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Pathogenesis of Enterovirus 71 Brainstem Encephalitis in Pediatric Patients: Roles of Cytokines and Cellular Immune Activation in Patients with Pulmonary Edema
Abstract
Taiwan experienced several epidemics of enterovirus 71 (EV71) infections, which were associated with brainstem encephalitis (BE) and pulmonary edema (PE). To elucidate the role of immune mechanisms in the pathogenesis of BE caused by EV71 and its fatal complication, PE, we analyzed the laboratory findings, cytokine, and immunophenotypes of 73 EV71-infected patients with BE. Patients were stratified by disease: PE (n=14), autonomic nervous system (ANS) dysregulation (n=25), and isolated BE (n=34). The mortality rate for PE was 64.3%. Leukocytosis and thrombocytosis were significantly more frequent among patients with PE. A significant elevation of plasma interleukin (IL)-10, IL-13, and interferon (IFN)-gamma levels observed in patients with PE. Patients with PE also had lower circulating CD4(+) T cells, CD8(+) T cells, and natural killer (NK) cells. An extensive peripheral and central nervous system inflammatory response with abnormal IL-10, IL-13, and IFN-gamma cytokine production and lymphocyte depletion appears to be responsible for the pathogenesis of EV71-associated PE.
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Cites
CELLULAR RESPONSES TO INTERFERON-γ
Boehm, U., Klamp, T., Groot, M., & Howard, J. C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.749 · Cited by 2,890
Cited by
An interferon‐γ‐related cytokine storm in SARS patients
Huang, K., Su, I., Theron, M., Wu, Y., Lai, S., Liu, C., & Lei, H. (2005) · Journal of Medical Virology · doi:10.1002/jmv.20255 · Cited by 679
Self-citationRetrograde Axonal Transport: a Major Transmission Route of Enterovirus 71 in Mice
Chen, C.-S., Yao, Y.-C., Lin, S.-C., Lee, Y.-P., Wang, Y.-F., Wang, J.-R., Liu, C.-C., Lei, H.-Y., & Yu, C.-K. (2007) · Journal of Virology · doi:10.1128/jvi.00236-07 · Cited by 178
Self-citationWong, K. T., Munisamy, B., Ong, K. C., Kojima, H., Noriyo, N., Chua, K. B., Ong, B. B., & Nagashima, K. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318163a990 · Cited by 159
Neural pathogenesis of enterovirus 71 infection
Weng, K.-F., Chen, L.-L., Huang, P.-N., & Shih, S.-R. (2010) · Microbes and Infection · doi:10.1016/j.micinf.2010.03.006 · Cited by 146
Neurotropic Enterovirus Infections in the Central Nervous System
Huang, H.-I., & Shih, S.-R. (2015) · Viruses · doi:10.3390/v7112920 · Cited by 130
Metadata
- Authors
- Wang, S., Lei, H., Huang, K., Wu, J., Wang, J., Yu, C., Su, I., & Liu, C.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-08-15
- Volume
- 188
- Issue
- 4
- Pages
- 564-570
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2054662375
- Cited by
- 290
- References
- 1
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, S., Lei, H., Huang, K., Wu, J., Wang, J., Yu, C., Su, I., & Liu, C. (2003). Pathogenesis of Enterovirus 71 Brainstem Encephalitis in Pediatric Patients: Roles of Cytokines and Cellular Immune Activation in Patients with Pulmonary Edema. The Journal of Infectious Diseases. https://doi.org/10.1086/376998
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