An interferon‐γ‐related cytokine storm in SARS patients
Open accessAbstract
Fourteen cytokines or chemokines were analyzed on 88 RT‐PCR‐confirmed severe acute respiratory syndrome (SARS) patients. IFN‐γ, IL‐18, TGF‐β, IL‐6, IP‐10, MCP‐1, MIG, and IL‐8, but not of TNF‐α, IL‐2, IL‐4, IL‐10, IL‐13, or TNFRI, were highly elevated in the acute phase sera of Taiwan SARS patients. IFN‐γ was significantly higher in the Ab(+) group than in the Ab(−) group. IFN‐γ, IL‐18, MCP‐1, MIG, and IP‐10 were already elevated at early days post fever onset. Furthermore, levels of IL‐18, IP‐10, MIG, and MCP‐1 were significantly higher in the death group than in the survival group. For the survival group, IFN‐γ and MCP‐1 were inversely associated with circulating lymphocytes count and monocytes count, but positively associated with circulating neutrophils count. It is concluded that an interferon‐γ‐related cytokine storm was induced post SARS coronavirus infection, and this cytokine storm might be involved in the immunopathological damage in SARS patients. J. Med. Virol. 75:185–194, 2005. © 2004 Wiley‐Liss, Inc.
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Cytokine storm was reported in patients with SARS and was associated with poor outcomes.
“Cytokine storm was also reported in patients with SARS and was associated with poor outcomes.86”
From Cytokine storm (2020) · cites this paper as [86]
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- Authors
- Huang, K., Su, I., Theron, M., Wu, Y., Lai, S., Liu, C., & Lei, H.
- Affiliations
- National Cheng Kung University (TW)
- National Health Research Institutes (TW)
- Department of Health (TW)
- Corresponding author
- Lei, Huan‐Yao
- Venue
- Journal of Medical Virology
- Publisher
- Wiley
- Published
- 2004-12-15
- Volume
- 75
- Issue
- 2
- Pages
- 185-194
- ISSN
- 0146-6615 (ISSN-L)
- 1096-9071
- PMC
- PMC7166886
- OpenAlex
- W2096092997
- Cited by
- 679
- References
- 31
- Citations by year
- 2026: 2 · 2025: 15 · 2024: 31 · 2023: 57 · 2022: 64 · 2021: 156 · 2020: 197 · 2019: 7 · 2018: 8 · 2017: 8 · 2016: 9 · 2015: 8 · 2014: 13 · 2013: 14 · 2012: 8
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Medical Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Centers for Disease Control and Prevention
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- SARS, SARS coronavirus, cytokine storm, interferon-gamma, IL-18, MCP-1, CXCL10, MIG, interleukin-6, TGF-beta, chemokines, immunopathology, SARS mortality, lymphocyte count, monocytes, neutrophils
- MeSH terms
- Adult, Aged, Antibodies, Viral, Female, Humans, Interferon-gamma, Male, Middle Aged, Taiwan, Cytokines, Chemokines, Severe Acute Respiratory Syndrome
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