The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Association between Adherence to Antiretroviral Therapy and Human Immunodeficiency Virus Drug Resistance
Open accessAbstract
Nonadherence to highly active antiretroviral therapy (HAART) is a major cause of human immunodeficiency virus (HIV) drug resistance; however the level of nonadherence associated with the greatest risk of resistance is unknown. Beginning in February 2000, 195 patients at the Johns Hopkins Outpatient Center (Baltimore, MD) who were receiving HAART and who had HIV loads of <500 copies/mL were recruited into a cohort study and observed for 1 year. At each visit, adherence to HAART was assessed and plasma samples were obtained and stored for resistance testing, if indicated. The overall incidence of viral rebound with clinically significant resistance was 14.5 cases per 100 person-years. By multivariate Cox proportional hazards regression, a cumulative adherence of 70%-89%, a CD4 cell nadir of <200 cells/microL, and the missing of a scheduled clinic visit in the past month were independently associated with an increased hazard of viral rebound with clinically significant resistance. Clinicians and patients must set high adherence goals to avoid the development of resistance.
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Citations
Cites
Chesney, M. A., Ickovics, J. R., Chambers, D. B., Gifford, A. L., Neidig, J., Zwickl, B., Wu, A. W., & PATIENT CARE COMMITTEE & ADHERENCE (2000) · AIDS Care · doi:10.1080/09540120050042891 · Cited by 1,428 · cited 1×
“The ART adherence instrument was modeled after the Adult AIDS Clinical Trials Group questionnaire [7] and supplemented with pictures of specific antiretrovirals [8].”
Method
Cited by
An information-motivation-behavioral skills model of adherence to antiretroviral therapy.
Fisher, J. D., Fisher, W. A., Amico, K. R., & Harman, J. J. (2006) · Health Psychology · doi:10.1037/0278-6133.25.4.462 · Cited by 696
Retention in Care: A Challenge to Survival with HIV Infection
Giordano, T. P., Gifford, A. L., White, A. C., Almazor, M. E. S., Rabeneck, L., Hartman, C., Backus, L. I., Mole, L. A., & Morgan, R. O. (2007) · Clinical Infectious Diseases · doi:10.1086/516778 · Cited by 566
Adherence to Highly Active Antiretroviral Therapy (HAART): A Meta-Analysis
Ortego, C., Huedo-Medina, T. B., Llorca, J., Sevilla, L., Santos, P., Rodríguez, E., Warren, M. R., & Vejo, J. (2011) · AIDS and Behavior · doi:10.1007/s10461-011-9942-x · Cited by 310
Nachega, J. B., Hislop, M., Dowdy, D. W., Lo, M., Omer, S. B., Regensberg, L., Chaisson, R. E., & Maartens, G. (2006) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000225015.43266.46 · Cited by 270
de Bruin, M. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.536 · Cited by 181
Metadata
- Authors
- Sethi, A. K., Celentano, D. D., Gange, S. J., Moore, R. D., & Gallant, J. E.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-10-15
- Volume
- 37
- Issue
- 8
- Pages
- 1112-1118
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2108723265
- Cited by
- 475
- References
- 1
- FWCI
- 14.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
