The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.
Changes in the Levels of Chemokines and Cytokines in the Placentas of Women with Plasmodium falciparum Malaria
Abstract
Plasmodium falciparum-infected erythrocytes often are sequestered in the placenta and stimulate the accumulation of maternal mononuclear cells. In this study, the role that chemokines and cytokines play in mediating the inflammatory response was investigated. Placental parasites elicited a statistically significant increase in the levels of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-10, in plasma collected from the intervillous space. Explants of fetal tissue from malaria-positive placentas also secreted significantly enhanced amounts of IFN-gamma. Culture supernatant of maternal intervillous leukocytes obtained from infected placentas contained significantly higher levels of TNF-alpha, IL-10, monocyte chemotactic protein-1, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and IFN-gamma inducible protein-10 than did cultures of white blood cells obtained from uninfected placentas. Taken together, these results show that both fetal and maternal cells secrete inflammatory and immunoregulatory cytokines in response to P. falciparum and suggest that beta-chemokines produced by maternal cells contribute to the accumulation of macrophages in the intervillous space.
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“In addition, activation of immune cells with upregulation of markers such as CD4 + , CD8 + and CD68 + can be observed [121, 123, 124].”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [123]
In the citing paper
“PM is associated with inflammatory immune responses [75–79], with increased levels of soluble mediators like TNF-α, TNF receptor I, TNF receptor II and IL-10 in peripheral blood [80,81].”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [76]
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No adjustments are needed for multiple comparisons.
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Adherence of Plasmodium falciparum to Chondroitin Sulfate A in the Human Placenta
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The burden of malaria in pregnancy in malaria-endemic areas
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Th 1-type immunity is incompatible with successful pregnancy
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The Impact of Placental Malaria on Gestational Age and Birth Weight
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The Role of T H 1 and T H 2 Cells in a Rodent Malaria Infection
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Chemokines: signal lamps for trafficking of T and B cells for development and effector function
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Cited by
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Malaria in pregnancy: pathogenesis and immunity
Rogerson, S. J., Hviid, L., Duffy, P. E., Leke, R. F., & Taylor, D. W. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70022-1 · Cited by 628
Self-citationter Kuile, F. O., Parise, M. E., Verhoeff, F. H., Udhayakumar, V., Newman, R. D., van Eijk, A. M., Rogerson, S. J., & Steketee, R. W. (2004) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2004.71.41 · Cited by 364
Human malarial disease: a consequence of inflammatory cytokine release
Clark, I. A., Budd, A. C., Alleva, L. M., & Cowden, W. B. (2006) · Malaria Journal · doi:10.1186/1475-2875-5-85 · Cited by 318
Placental Responses to Changes in the Maternal Environment Determine Fetal Growth
Dimasuay, K. G., Boeuf, P., Powell, T. L., & Jansson, T. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00012 · Cited by 258
Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children
Armah, H. B., Wilson, N. O., Sarfo, B. Y., Powell, M. D., Bond, V. C., Anderson, W. A., Adjei, A. A., Gyasi, R. K., Tettey, Y., Wiredu, E. K., et al. (2007) · Malaria Journal · doi:10.1186/1475-2875-6-147 · Cited by 239
Metadata
- Authors
- Suguitan, Jr., Leke, R. G. F., Fouda, G., Zhou, A., Thuita, L., Metenou, S., Fogako, J., Megnekou, R., & Taylor, D. W.
- Affiliations
- Université de Yaoundé I (CM)
- Georgetown University (US)
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2003-10
- Volume
- 188
- Issue
- 7
- Pages
- 1074-7082
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2096731679
- Cited by
- 161
- References
- 44
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 13
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (U01A1 43888)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- Plasmodium falciparum, malaria in pregnancy, placenta, chemokines, cytokines, interferon-gamma, TNF-α, IL-10, MCP-1, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1β, CXCL10, fetal tissue, placental inflammation, macrophage accumulation, immune regulation
- MeSH terms
- Adult, Animals, Cameroon, Enzyme-Linked Immunosorbent Assay, Female, Fetus, Hematocrit, Humans, Immunohistochemistry, Leukocyte Count, Placenta, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Parasitic, Cytokines, Malaria, Falciparum, Parasitemia, Chemokines
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