Cited by 161Malaria Research and ControlPregnancy and preeclampsia studiesReproductive System and Pregnancy

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Changes in the Levels of Chemokines and Cytokines in the Placentas of Women with Plasmodium falciparum Malaria

Suguitan, Jr., Amorsolo L., Leke, Rose G. F., Fouda, Genevieve, Zhou, Ainong, Thuita, Lucy, Metenou, Simon, Fogako, Josephine, Megnekou, Rosette, Taylor, Diane Wallace·2003·The Journal of Infectious Diseases

DOI 10.1086/378500

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Abstract

Plasmodium falciparum-infected erythrocytes often are sequestered in the placenta and stimulate the accumulation of maternal mononuclear cells. In this study, the role that chemokines and cytokines play in mediating the inflammatory response was investigated. Placental parasites elicited a statistically significant increase in the levels of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-10, in plasma collected from the intervillous space. Explants of fetal tissue from malaria-positive placentas also secreted significantly enhanced amounts of IFN-gamma. Culture supernatant of maternal intervillous leukocytes obtained from infected placentas contained significantly higher levels of TNF-alpha, IL-10, monocyte chemotactic protein-1, macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and IFN-gamma inducible protein-10 than did cultures of white blood cells obtained from uninfected placentas. Taken together, these results show that both fetal and maternal cells secrete inflammatory and immunoregulatory cytokines in response to P. falciparum and suggest that beta-chemokines produced by maternal cells contribute to the accumulation of macrophages in the intervillous space.

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Authors: Suguitan, Jr., Leke, R. G. F., Fouda, G., Zhou, A., Thuita, L., Metenou, S., Fogako, J., Megnekou, R., & Taylor, D. W.
Affiliations: Université de Yaoundé I (CM)
Georgetown University (US)
ORCID: Fouda, Genevieve
Thuita, Lucy
Megnekou, Rosette
Taylor, Diane Wallace
Venue: The Journal of Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2003-10
Volume: 188
Issue: 7
Pages: 1074-7082
ISSN: 0022-1899 (ISSN-L)
1537-6613
DOI: 10.1086/378500
OpenAlex: W2096731679
Cited by: 161
References: 44
Citations by year: 2026: 4 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 11 · 2014: 8 · 2013: 10 · 2012: 13
FWCI: 8.12
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Public Health Service (U01A1 43888)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords: Plasmodium falciparum, malaria in pregnancy, placenta, chemokines, cytokines, interferon-gamma, TNF-α, IL-10, MCP-1, macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1β, CXCL10, fetal tissue, placental inflammation, macrophage accumulation, immune regulation
MeSH terms: Adult, Animals, Cameroon, Enzyme-Linked Immunosorbent Assay, Female, Fetus, Hematocrit, Humans, Immunohistochemistry, Leukocyte Count, Placenta, Plasmodium falciparum, Pregnancy, Pregnancy Complications, Parasitic, Cytokines, Malaria, Falciparum, Parasitemia, Chemokines

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Changes in the Levels of Chemokines and Cytokines in the Placentas of Women with Plasmodium falciparum Malaria

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