The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Serum Procalcitonin and C-Reactive Protein Levels as Markers of Bacterial Infection: A Systematic Review and Meta-analysis
Abstract
A meta-analysis was performed to evaluate the accuracy of determination of procalcitonin (PCT) and C-reactive protein (CRP) levels for the diagnosis of bacterial infection. The analysis included published studies that evaluated these markers for the diagnosis of bacterial infections in hospitalized patients. PCT level was more sensitive (88% [95% confidence interval [CI], 80%-93%] vs. 75% [95% CI, 62%-84%]) and more specific (81% [95% CI, 67%-90%] vs. 67% [95% CI, 56%-77%]) than CRP level for differentiating bacterial from noninfective causes of inflammation. The Q value for PCT markers was higher (0.82 vs. 0.73). The sensitivity for differentiating bacterial from viral infections was also higher for PCT markers (92% [95% CI, 86%-95%] vs. 86% [95% CI, 65%-95%]); the specificities were comparable (73% [95% CI, 42%-91%] vs. 70% [95% CI, 19%-96%]). The Q value was higher for PCT markers (0.89 vs. 0.83). PCT markers also had a higher positive likelihood ratio and lower negative likelihood ratio than did CRP markers in both groups. On the basis of this analysis, the diagnostic accuracy of PCT markers was higher than that of CRP markers among patients hospitalized for suspected bacterial infections.
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Cites
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Cited by
Procalcitonin as a diagnostic marker for sepsis: A systematic review and meta-analysis.
Wacker, C., Prkno, A., Brunkhorst, F. M., & Schlattmann, P. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(12)70323-7 · Cited by 1,198
Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults
Xia, W., Shao, J., Guo, Y., Peng, X., Li, Z., & Hu, D. (2020) · Pediatric Pulmonology · doi:10.1002/ppul.24718 · Cited by 1,057
Sepsis: a roadmap for future research
Cohen, J., Vincent, J.-L., Adhikari, N. K. J., Machado, F. R., Angus, D. C., Calandra, T., Jaton, K., Giulieri, S., Delaloye, J., Opal, S., et al. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)70112-x · Cited by 992
Tang, B. M., Eslick, G. D., Craig, J. C., & McLean, A. S. (2007) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(07)70052-x · Cited by 851
de Jong, E., van Oers, J. A., Beishuizen, A., Vos, P., Vermeijden, W. J., Haas, L. E., Loef, B. G., Dormans, T., van Melsen, G. C., Kluiters, Y. C., et al. (2016) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(16)00053-0 · Cited by 836
Metadata
- Authors
- Simon, L., Gauvin, F., Amre, D. K., Saint-Louis, P., & Lacroix, J.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2004-07-15
- Volume
- 39
- Issue
- 2
- Pages
- 206-217
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2138904389
- Cited by
- 1,787
- References
- 9
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Simon, L., Gauvin, F., Amre, D. K., Saint-Louis, P., & Lacroix, J. (2004). Serum Procalcitonin and C-Reactive Protein Levels as Markers of Bacterial Infection: A Systematic Review and Meta-analysis. Clinical Infectious Diseases. https://doi.org/10.1086/421997
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