Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults
Open accessAbstract
Purpose To discuss the different characteristics of clinical, laboratory, and chest computed tomography (CT) in pediatric patients from adults with 2019 novel coronavirus (COVID-19) infection. Methods The clinical, laboratory, and chest CT features of 20 pediatric inpatients with COVID-19 infection confirmed by pharyngeal swab COVID-19 nucleic acid test were retrospectively analyzed during 23 January and 8 February 2020. The clinical and laboratory information was obtained from inpatient records. All the patients were undergone chest CT in our hospital. Results Thirteen pediatric patients (13/20, 65%) had an identified history of close contact with COVID-19 diagnosed family members. Fever (12/20, 60%) and cough (13/20, 65%) were the most common symptoms. For laboratory findings, procalcitonin elevation (16/20, 80%) should be pay attention to, which is not common in adults. Coinfection (8/20, 40%) is common in pediatric patients. A total of 6 patients presented with unilateral pulmonary lesions (6/20, 30%), 10 with bilateral pulmonary lesions (10/20, 50%), and 4 cases showed no abnormality on chest CT (4/20, 20%). Consolidation with surrounding halo sign was observed in 10 patients (10/20, 50%), ground-glass opacities were observed in 12 patients (12/20, 60%), fine mesh shadow was observed in 4 patients (4/20, 20%), and tiny nodules were observed in 3 patients (3/20, 15%). Conclusion Procalcitonin elevation and consolidation with surrounding halo signs were common in pediatric…
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Inflammatory serological markers usually associated with bacterial infection may appear in patients with COVID-19 without a corresponding bacterial co-infection.
“there is evidence that the inflammatory serological markers that are usually associated with bacterial infection, such as raised procalcitonin and C-reactive protein, may appear in patients with COVID-19 without a corresponding bacterial co-infection occurring.12 , 13”
From Co-infections in people with COVID-19: a systematic review and meta-analysis. (2020) · cites this paper as [13]
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- Authors
- Xia, W., Shao, J., Guo, Y., Peng, X., Li, Z., & Hu, D.
- Affiliations
- Wuhan Children's Hospital (CN)
- Tongji Hospital (CN)
- Corresponding author
- Shao, Jianbo
- Venue
- Pediatric Pulmonology
- Publisher
- Wiley
- Published
- 2020-03-05
- Volume
- 55
- Issue
- 5
- Pages
- 1169-1174
- ISSN
- 1099-0496 (ISSN-L)
- 8755-6863
- PMC
- PMC7168071
- OpenAlex
- W3010375169
- Cited by
- 1,057
- References
- 12
- Citations by year
- 2026: 4 · 2025: 18 · 2024: 21 · 2023: 65 · 2022: 103 · 2021: 328 · 2020: 517 · 2019: 1
- FWCI
- 33.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pediatric Pulmonology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- COVID-19 pandemic, pediatric patients, chest CT findings, procalcitonin, co-infection, halo sign, ground-glass opacities, lung consolidation, clinical features, laboratory findings, close contact transmission
- MeSH terms
- Betacoronavirus, Procalcitonin, COVID-19, SARS-CoV-2, Adolescent, Age Factors, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Lung, Male, Pediatrics, Pneumonia, Viral, Retrospective Studies, Tomography, X-Ray Computed, Coronavirus Infections, Pandemics
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