Cited by 120Cystic Fibrosis Research AdvancesAntifungal resistance and susceptibilityImmunodeficiency and Autoimmune Disorders

Influence of Interleukin‐10 on Aspergillus fumigatus Infection in Patients with Cystic Fibrosis

Brouard, Jacques, Knauer, Nicola, Boelle, Pierre‐Yves, Corvol, Harriet, Henrion‐Caude, Alexandra, Flamant, Cyril, Bremont, François, Delaisi, Bertrand +10 more·2005·The Journal of Infectious Diseases

Abstract

Recent evidence suggests that genetic polymorphisms that affect the production of interleukin (IL)-10 may play a role in the response to pathogens in cystic fibrosis (CF). The present study was designed to investigate a possible association between alleles carried at position -1082 in the promoter region of the IL-10 gene and clinical data on 378 patients with CF. After adjustment for potential confounding variables, a significant relationship was found between the -1082GG genotype and both colonization with Aspergillus fumigatus and allergic bronchopulmonary aspergillosis. In addition, higher serum levels of IL-10 were observed in patients colonized with A. fumigatus. These results suggest that polymorphisms in the promoter region of the IL-10 gene may influence the host response to A. fumigatus in the context of CF.

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Crossref · 10.1086/429964

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  • Polymorphisms in several cytokines are associated with susceptibility to specific fungal diseases: aspergillosis with IL-1, IL-10, IL-15, and IL-23; candidiasis with IL-4; paracoccidioidomycosis with IL-4; and blastomycosis with IL-6.

    “polymorphisms in a number of cytokines have also been found to predispose to fungal disease: aspergillosis (IL-1 [30], IL-10 [31,32], IL-15 [32], and IL-23); candidiasis (IL-4) [33,34]; paracoccidioidomycosis (IL-4) [35]; and blastomycosis (IL-6) [36].”

    From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [31]

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Authors
Brouard, J., Knauer, N., Boelle, P., Corvol, H., Henrion‐Caude, A., Flamant, C., Bremont, F., Delaisi, B., Duhamel, J., Marguet, C., Roussey, M., Miesch, M., Chadelat, K., Boule, M., Fauroux, B., Ratjen, F., Grasemann, H., & Clement, A.
Affiliations
  • Inserm (FR)
  • Hôpital Robert-Debré (FR)
  • Hôpital Charles-Nicolle (FR)
  • Essen University Hospital (DE)
Venue
The Journal of Infectious Diseases
Published
2005-06
Volume
191
Issue
11
Pages
1988-1991
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
OpenAlex
W2144375300
Cited by
120
References
15
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 1 · 2019: 2 · 2018: 7 · 2017: 7 · 2016: 5 · 2014: 13 · 2013: 5 · 2012: 7
FWCI
6.39
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords
IL-10, Aspergillus fumigatus, cystic fibrosis, allergic bronchopulmonary aspergillosis, IL-10 gene polymorphism, genetic susceptibility, fungal colonization, host immune response, serum IL-10 levels
MeSH terms
Adolescent, Aspergillosis, Aspergillus fumigatus, Child, Child, Preschool, Cystic Fibrosis, Humans, Lung Diseases, Fungal, Polymorphism, Genetic, Interleukin-10

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