Influence of Interleukin‐10 on Aspergillus fumigatus Infection in Patients with Cystic Fibrosis
Abstract
Recent evidence suggests that genetic polymorphisms that affect the production of interleukin (IL)-10 may play a role in the response to pathogens in cystic fibrosis (CF). The present study was designed to investigate a possible association between alleles carried at position -1082 in the promoter region of the IL-10 gene and clinical data on 378 patients with CF. After adjustment for potential confounding variables, a significant relationship was found between the -1082GG genotype and both colonization with Aspergillus fumigatus and allergic bronchopulmonary aspergillosis. In addition, higher serum levels of IL-10 were observed in patients colonized with A. fumigatus. These results suggest that polymorphisms in the promoter region of the IL-10 gene may influence the host response to A. fumigatus in the context of CF.
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Polymorphisms in several cytokines are associated with susceptibility to specific fungal diseases: aspergillosis with IL-1, IL-10, IL-15, and IL-23; candidiasis with IL-4; paracoccidioidomycosis with IL-4; and blastomycosis with IL-6.
“polymorphisms in a number of cytokines have also been found to predispose to fungal disease: aspergillosis (IL-1 [30], IL-10 [31,32], IL-15 [32], and IL-23); candidiasis (IL-4) [33,34]; paracoccidioidomycosis (IL-4) [35]; and blastomycosis (IL-6) [36].”
From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [31]
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Moss, R. B. (2014) · ASM Press eBooks · doi:10.1128/9781555815523.ch26 · Cited by 6 · see citing works
Infections fongiques au cours de la mucoviscidose
Bourgeois, M. L., Sermet‐Gaudelus, I., Bailly-Botuha, C., Delacourt, C., & Jacques de, B. L. I. C. (2011) · Archives de Pédiatrie · doi:10.1016/s0929-693x(11)70936-8 · Cited by 5 · see citing works
Aspergillose nécrosante semi invasive chez un enfant de 14 ans atteint de mucoviscidose
Bonnel, A.-S., Quinque, K., Roux, P. L., & Luyer, B. L. (2006) · Revue des Maladies Respiratoires · doi:10.1016/s0761-8425(06)71600-x · Cited by 4 · see citing works
Allergic bronchopulmonary aspergillosis and other fungal diseases
Hilvering, B., Speirs, J. J., van der Ent, C. K., & Beekman, J. M. (2011) · European Respiratory Society eBooks · doi:10.1183/1025448x.10003710 · Cited by 4 · see citing works
Biologics Use in Eosinophilic Lung Disease: Controversies and Consensus
de Llano, L. P., Dacal-Rivas, D., Pavord, I. D., ASLAM, M. M. S., & Lugogo, N. L. (2026) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2026.01.022 · Cited by 3 · see citing works
Impact of Gene Modifiers on Cystic Fibrosis Phenotypic Profiles: A Systematic Review
Ward, A., Mauleon, R., Ooi, C. Y., & Rosic, N. N. (2024) · Human Mutation · doi:10.1155/2024/6165547 · Cited by 3 · see citing works
Diagnosis and treatment of allergic bronchopulmonary aspergillosis
Tanner, N. T., & Judson, M. A. (2008) · Current Fungal Infection Reports · doi:10.1007/s12281-008-0029-8 · Cited by 3 · see citing works
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Allergic Aspects of Aspergillosis
Knutsen, A. P. (2013) · Current Fungal Infection Reports · doi:10.1007/s12281-013-0153-y · Cited by 3 · see citing works
Environmental Exposures in the Normal Host
Knutsen, A. P., Temprano, J., Wooldridge, J. L., Bhatla, D., & Slavin, R. G. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-1984-0.00059-0 · Cited by 3 · see citing works
Immunogenetics of Chronic and Allergic Aspergillosis
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Immunopathogenesis of Aspergillosis
Singh, S., Kanaujia, R., & Rudramurthy, S. M. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.98782 · Cited by 4 · see citing works
Allergic Bronchopulmonary Aspergillosis
Stahlbaum, D., Patterson, K. C., & Strek, M. E. (2023) · Springer eBooks · doi:10.1007/978-3-031-12950-6_4 · Cited by 2 · see citing works
Hypersensitivity Pneumonitis and Eosinophilic Lung Diseases
Knutsen, A. P., Temprano, J., Bhatla, D., & Slavin, R. G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-44887-1.00065-1 · Cited by 2 · see citing works
Allergic Bronchopulmonary Aspergillosis
Moss, R. B. (2008) · Elsevier eBooks · doi:10.1016/b978-032304048-8.50050-5 · Cited by 2 · see citing works
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- Authors
- Brouard, J., Knauer, N., Boelle, P., Corvol, H., Henrion‐Caude, A., Flamant, C., Bremont, F., Delaisi, B., Duhamel, J., Marguet, C., Roussey, M., Miesch, M., Chadelat, K., Boule, M., Fauroux, B., Ratjen, F., Grasemann, H., & Clement, A.
- Affiliations
- Inserm (FR)
- Hôpital Robert-Debré (FR)
- Hôpital Charles-Nicolle (FR)
- Essen University Hospital (DE)
- ORCID
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-06
- Volume
- 191
- Issue
- 11
- Pages
- 1988-1991
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2144375300
- Cited by
- 120
- References
- 15
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 1 · 2019: 2 · 2018: 7 · 2017: 7 · 2016: 5 · 2014: 13 · 2013: 5 · 2012: 7
- FWCI
- 6.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Keywords
- IL-10, Aspergillus fumigatus, cystic fibrosis, allergic bronchopulmonary aspergillosis, IL-10 gene polymorphism, genetic susceptibility, fungal colonization, host immune response, serum IL-10 levels
- MeSH terms
- Adolescent, Aspergillosis, Aspergillus fumigatus, Child, Child, Preschool, Cystic Fibrosis, Humans, Lung Diseases, Fungal, Polymorphism, Genetic, Interleukin-10
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