The DOI matches its Crossref record; 75 of the 78 references it cites were found in a registry or an index.
Allelic Heterogeneity at the Serotonin Transporter Locus (SLC6A4) Confers Susceptibility to Autism and Rigid-Compulsive Behaviors
Open accessAbstract
Autism is a spectrum of neurodevelopmental disorders with a primarily genetic etiology exhibiting deficits in (1) development of language and (2) social relationships and (3) patterns of repetitive, restricted behaviors or interests and resistance to change. Elevated platelet serotonin (5-HT) in 20%-25% of cases and efficacy of selective 5-HT reuptake inhibitors (SSRIs) in treating anxiety, depression, and repetitive behaviors points to the 5-HT transporter (5-HTT; SERT) as a strong candidate gene. Association studies involving the functional insertion/deletion polymorphism in the promoter (5-HTTLPR) and a polymorphism in intron 2 are inconclusive, possibly because of phenotypic heterogeneity. Nonetheless, mounting evidence for genetic linkage of autism to the chromosome 17q11.2 region that harbors the SERT locus (SLC6A4) supports a genetic effect at or near this gene. We confirm recent reports of sex-biased genetic effects in 17q by showing highly significant linkage driven by families with only affected males. Association with common alleles fails to explain observed linkage; therefore, we hypothesized that preferential transmission of multiple alleles does explain it. From 120 families, most contributing to linkage at 17q11.2, we found four coding substitutions at highly conserved positions and 15 other variants in 5' noncoding and other intronic regions transmitted in families exhibiting increased rigid-compulsive behaviors. In the aggregate, these variants show significant linkage to and association with autism. Our data provide strong support for a collection of multiple, often rare, alleles at SLC6A4 as imposing risk of autism.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The most common of these variants, SERT Ala56, was found to be associated with both rigid-compulsive behavior and sensory aversion [53, 54].”
From Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders (2018) · cites this paper as [53]
Citations
Cites
(1943) · The Nervous child · Cited by 8,870
Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162
A high-resolution recombination map of the human genome
Kong, A., Gudbjartsson, D. F., Sainz, J., Jonsdottir, G. M., Gudjonsson, S. A., Richardsson, B., Sigurdardottir, S. L., Barnard, J., Hallbeck, B., Másson, G., et al. (2002) · Nature Genetics · doi:10.1038/ng917 · Cited by 1,750
Characterization of single-nucleotide polymorphisms in coding regions of human genes
Cargill, M., Altshuler, D., Ireland, J., Sklar, P., Ardlie, K., Patil, N., Lane, C. R., Lim, E. P., Kalyanaraman, N., Nemesh, J., et al. (1999) · Nature Genetics · doi:10.1038/10290 · Cited by 1,547
Prevalence of Autism in a US Metropolitan Area
Yeargin-Allsopp, M., Rice, C., Karapurkar, T., Doernberg, N., Boyle, C., & Murphy, C. (2003) · JAMA · doi:10.1001/jama.289.1.49 · Cited by 1,248
Pervasive Developmental Disorders in preschool children
Chakrabarti, S. (2001) · JAMA · doi:10.1001/jama.285.24.3093 · Cited by 1,132
Nickerson, D. A. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.14.2745 · Cited by 929
The TDT and other family-based tests for linkage disequilibrium and association.
(1996) · PubMed Central · Cited by 901
Nomenclature for the description of human sequence variations
den Dunnen, J., & Antonarakis, S. E. (2001) · Human Genetics · doi:10.1007/s004390100505 · Cited by 899
Allegro, a new computer program for multipoint linkage analysis
Gudbjartsson, D. F., Jónasson, K., Frigge, M. L., & Kong, A. (2000) · Nature Genetics · doi:10.1038/75514 · Cited by 785
Genetics of austim: complex aetiology for a heterogeneous disorder
Folstein, S. E., & Rosen-Sheidley, B. (2001) · Nature Reviews Genetics · doi:10.1038/35103559 · Cited by 771
Self-citationA Genomic Screen of Autism: Evidence for a Multilocus Etiology
Risch, N., Spiker, D., Lotspeich, L., Nouri, N., Hinds, D., Hallmayer, J., Kalaydjieva, L., McCague, P., Dimiceli, S., Pitts, T., et al. (1999) · The American Journal of Human Genetics · doi:10.1086/302497 · Cited by 684
Fombonne, E. (2003) · JAMA · doi:10.1001/jama.289.1.87 · Cited by 604
Genomic variants in exons and introns: identifying the splicing spoilers
Pagani, F., & Baralle, F. E. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1327 · Cited by 601
Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children
Schain, R. J., & Freedman, D. X. (1961) · The Journal of Pediatrics · doi:10.1016/s0022-3476(61)80261-8 · Cited by 579
Bailey, A. J., Amaia Hervas, G., Matthews, N., Palferman, S., Wallace, S., Aubin, A., Michelotti, J., Wainhouse, C., Papanikolaou, Κ., Rutter, M. L., et al. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.3.571 · Cited by 543
A Test for Linkage and Association in General Pedigrees: The Pedigree Disequilibrium Test
Martin, E. R., Monks, S. A., Warren, L. L., & Kaplan, N. L. (2000) · The American Journal of Human Genetics · doi:10.1086/302957 · Cited by 537
Polymorphism in serotonin transporter gene associated with susceptibility to major depression
Ogilvie, A. D., Battersby, S., Fink, G., Harmar, A. J., Goodwin, G. M., Bubb, V. J., & Smith, C. A. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90079-3 · Cited by 534
Genome-Wide Scan for Autism Susceptibility Genes
Philippe, A., Martinez, M., Guilloud-Bataille, M., Gillberg, C., Rastam, M., Sponheim, E., Coleman, M., Zappella, M., Aschauer, H., Van Maldergem, L., et al. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.5.805 · Cited by 471
A Genomewide Screen for Autism: Strong Evidence for Linkage to Chromosomes 2q, 7q, and 16p
(2001) · The American Journal of Human Genetics · doi:10.1086/323264 · Cited by 453
Evidence of linkage between the serotonin transporter and autistic disorder
Cook, E., Yeung-Courchesne, R., Lord, C., Cox, N. J., Yan, S., Lincoln, A. J., Haas, R., Courchesne, E., & LEVENTHAL, B. L. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000266 · Cited by 426
Hollander, E., Phillips, A., Chaplin, W. F., Zagursky, K., Novotny, S., Wasserman, S., & Iyengar, R. L. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300627 · Cited by 418
Genetic influences and infantile autism
FOLSTEIN, S., & RUTTER, M. (1977) · Nature · doi:10.1038/265726a0 · Cited by 400
Self-citationThe serotonin system in autism
Cook, E. H., & LEVENTHAL, B. L. (1996) · Current Opinion in Pediatrics · doi:10.1097/00008480-199608000-00008 · Cited by 394
Ramamoorthy, S., & Blakely, R. (1999) · Science · doi:10.1126/science.285.5428.763 · Cited by 392
Self-citationPickles, A. R., Bolton, P., Macdonald, H., Bailey, A., Couteur, A. S. L., Sim, C. H., & Rutter, M. L. (1995) · Europe PMC (PubMed Central) · Cited by 388
Autism, affective and other psychiatric disorders: Patterns of familial aggregation
BOLTON, P. F., PICKLES, A., MURPHY, M., & RUTTER, M. (1998) · Psychological Medicine · doi:10.1017/s0033291797006004 · Cited by 387
Qian, Y., Galli, A., Ramamoorthy, S., Risso, S., DeFelice, L. J., & Blakely, R. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00045.1997 · Cited by 381
Self-citationAutomated Finishing with AutofinishPreprint
Gordon, D., Desmarais, C., & Green, P. (2001) · Genome Research · doi:10.1101/gr.171401 · Cited by 376
MacKenzie, A., & Quinn, J. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15251 · Cited by 374
Evidence for a Susceptibility Gene for Autism on Chromosome 2 and for Genetic Heterogeneity
Buxbaum, J. D., Silverman, J. M., Smith, C. J., Kilifarski, M., Reichert, J. G., Hollander, E., LAWLOR, B. A., Fitzgerald, M., Greenberg, D. A., & Davis, K. L. (2001) · The American Journal of Human Genetics · doi:10.1086/320588 · Cited by 325
A genomewide screen for autism susceptibility loci
Liu, J., Nyholt, D. R., Magnussen, P., Parano, E., Pavone, P., Geschwind, D., Lord, C., Iversen, P., Hoh, J., Autism Genetic Resource Exchange Consortium, T., et al. (2001) · The American Journal of Human Genetics · doi:10.1086/321980 · Cited by 309
Pharmacogenetics and the serotonin system: initial studies and future directions
Veenstra-VanderWeele, J. M., Anderson, G. M., & Cook, E. H. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00814-1 · Cited by 292
AUTISM AS A PARADIGMATIC COMPLEX GENETIC DISORDER
Veenstra-VanderWeele, J. M., Christian, S. L., & Cook, E. H. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.180050 · Cited by 282
Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype
Ozaki, N., Goldman, D. A., Kaye, W. H., Plotnicov, K. H., Greenberg, B. D., Lappalainen, J., Rudnick, G., & Murphy, D. L. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001365 · Cited by 275
The UCLA-University of Utah epidemiologic survey of autism: prevalence
(1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.2.194 · Cited by 273
A Genomewide Screen of 345 Families for Autism-Susceptibility Loci
Yonan, A. L., Alarcón, M., Cheng, R., Magnusson, P. K. E., Spence, S. J., Palmer, A. A., Grunn, A., Juo, S. H., Terwilliger, J. D., Liu, J., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/378778 · Cited by 272
Serotonin transporter (5-HTT) gene variants associated with autism?
Klauck, S. M. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.13.2233 · Cited by 259
Genomic screen and follow‐up analysis for autistic disorder
Shao, Y., Wolpert, C. M., Raiford, K. L., Menold, M. M., Donnelly, S. L., Ravan, S. A., Bass, M. P., McClain, C., von Wendt, L., Vance, J. M., et al. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.10153 · Cited by 252
Zhu, C.-B., Carneiro, A. M., Dostmann, W. R., Hewlett, W. A., & Blakely, R. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410858200 · Cited by 228
Self-citationSamuvel, D. J., Jayanthi, L. D., Bhat, N. R., & Ramamoorthy, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3754-04.2005 · Cited by 215
Incorporating language phenotypes strengthens evidence of linkage to autism
Bradford, Y., Haines, J. L., Hutcheson, H. B., Gardiner, M., Braun, T. A., Sheffield, V. C., Cassavant, T., Huang, W. Q., Wang, K., Vieland, V. J., et al. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1497 · Cited by 205
Self-citationAdenosine A3 receptors regulate serotonin transport via nitric oxide and cGMP.
Miller, K. J., & Hoffman, B. J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46992-x · Cited by 199
Role of the serotonin transporter gene in the behavioral expression of autism
Tordjman, S., Gutknecht, L., Carlier, M., Spitz, E., Antoine, C., Slama, F., Carsalade, V, Cohen, D. J., Ferrari, P., Roubertoux, P. L., et al. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000873 · Cited by 196
Genetic Studies of Autistic Disorder and Chromosome 7
Ashley‐Koch, A. E., Wolpert, C. M., Menold, M. M., Zaeem, L., Basu, S., Donnelly, S. L., Ravan, S. A., Powell, C. M., Qumsiyeh, M. Β., Aylsworth, A. S., et al. (1999) · Genomics · doi:10.1006/geno.1999.5968 · Cited by 195
Autism and the serotonin transporter: the long and short of it
Devlin, B., Cook, E. H., Coon, H. H., Dawson, G., Grigorenko, E. L., McMahon, W., Minshew, N. J., Pauls, D. L., Smith, M., Spence, M. A., et al. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001724 · Cited by 189
Prasad, H. C., Zhu, C.-B., McCauley, J. L., Samuvel, D. J., Ramamoorthy, S., Shelton, R. C., Hewlett, W. A., Sutcliffe, J. S., & Blakely, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501432102 · Cited by 178
Self-citationEvidence for Sex-Specific Risk Alleles in Autism Spectrum Disorder
Stone, J. L., Merriman, B., Cantor, R. M., Yonan, A. L., Gilliam, T. C., Geschwind, D. H., & Nelson, S. F. (2004) · The American Journal of Human Genetics · doi:10.1086/426034 · Cited by 176
Further characterization of the autism susceptibility locus AUTS1 on chromosome 7q
International Molecular Genetic Study of Autism Consortium (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.9.973 · Cited by 176
A Principal Components Analysis of the Autism Diagnostic Interview-Revised
Tadevosyan-leyfer, O., Dowd, M., Mankoski, R., Winklosky, B., Putnam, S., McGrath, L., Tager-flusberg, H., & Folstein, S. E. (2003) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000046870.56865.90 · Cited by 173
Self-citationPhenotypic Homogeneity Provides Increased Support for Linkage on Chromosome 2 in Autistic Disorder
Shao, Y., Raiford, K. L., Wolpert, C. M., Cope, H., Ravan, S. A., Ashley‐Koch, A. E., Abramson, R. K., Wright, H. H., DeLong, R. G., Gilbert, J. R., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/339765 · Cited by 172
Evidence for an association with the serotonin transporter promoter region polymorphism and autism
Yirmiya, N., Pilowsky, T., Nemanov, L., Arbelle, S., Feinsilver, T., Fried, I., & Ebstein, R. P. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1365 · Cited by 171
McCauley, J. L., Li, C., Jiang, L., Olson, L. M., Crockett, G., Gainer, K., Folstein, S. E., Haines, J. L., & Sutcliffe, J. S. (2005) · BMC Medical Genetics · doi:10.1186/1471-2350-6-1 · Cited by 168
Self-citationZhu, C.-B., Hewlett, W. A., Feoktistov, I., Biaggioni, I., & Blakely, R. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.6.1462 · Cited by 168
Self-citationPlatelet serotonin studies in hyperserotonemic relatives of children with autistic disorder
Cook, E. H., Arora, R. C., Anderson, G. M., Berry‐Kravis, E., Yan, S., Yeoh, H. C., Sklena, P. J., Charak, D., & LEVENTHAL, B. L. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90685-v · Cited by 165
A Human Serotonin Transporter Mutation Causes Constitutive Activation of Transport Activity
Kilic, F., Murphy, D. L., & Rudnick, G. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.2.440 · Cited by 162
Replication of Autism Linkage: Fine-Mapping Peak at 17q21
Cantor, R. M., Kono, N., Duvall, J. A., Alvarez-Retuerto, A., Stone, J. L., Alarcón, M., Nelson, S. F., & Geschwind, D. H. (2005) · The American Journal of Human Genetics · doi:10.1086/430278 · Cited by 157 · cited 5×
“6 a more distal site in 17q21 (Cantor et al. 2005)—that overall linkage in this region represents two loci, with the likely stronger effect at SLC6A4.”
InfluentialGlatt, C. E., DeYoung, J. A., Delgado, S., Service, S. K., Giacomini, K. M., Edwards, R. H., Risch, N., & Freimer, N. B. (2001) · Nature Genetics · doi:10.1038/86948 · Cited by 154
Kim, S.-J., Cox, N. J., Yeung-Courchesne, R., Lord, C., Corsello, C. M., Akshoomoff, N., Guter, S. J., LEVENTHAL, B. L., Courchesne, E., & Cook, E. H. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001033 · Cited by 152
Buxbaum, J. D., Silverman, J. M., Keddache, M. A., Smith, C. J. W., Hollander, E., Ramoz, N., & Reichert, J. G. (2003) · Molecular Psychiatry · doi:10.1038/sj.mp.4001465 · Cited by 143
Hahn, M. K., & Blakely, R. (2002) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500106 · Cited by 141
Self-citationMcCauley, J. L., Olson, L. M., Dowd, M., Amin, T. T., Steele, A., Blakely, R., Folstein, S. E., Haines, J. L., & Sutcliffe, J. S. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20151 · Cited by 137
Self-citationSex-specific genetic architecture of whole blood serotonin levels
Weiss, L. A., Abney, M., Cook, E. H., & Ober, C. (2005) · The American Journal of Human Genetics · doi:10.1086/426697 · Cited by 137
Stoppage rules and genetic studies of autism
Jones, M. B., & Szatmári, P. (1988) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02211816 · Cited by 130
Rice, T., Përusse, L., Bouchard, C., & Rao, D. C. (1999) · Genetic Epidemiology · doi:10.1002/(sici)1098-2272(1999)16:3 · Cited by 116
Integrated platform for detection of DNA sequence variants using capillary array electrophoresis
Li, Q., Liu, Z., Monroe, H., & Culiat, C. T. (2002) · Electrophoresis · doi:10.1002/1522-2683(200205)23:10 · Cited by 112
Serotonin transporter gene and autism: a haplotype analysis in an Irish autistic population
Conroy, J., Meally, E., Kearney, G., Fitzgerald, M., Gill, M., & Gallagher, L. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001459 · Cited by 105
Auranen, M., Nieminen, T. T., Majuri, S., Vanhala, R., Peltonen, L., & Järvelä, I. E. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000708 · Cited by 55
Evaluation of linkage of markers on chromosome 6p with schizophrenia in Taiwanese families
Hwu, H., Lin, M., Lee, P.-C., Lee, S. F. ‐., Ouyang, W., & Liu, C. (2000) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(20000207)96:1 · Cited by 30
Prevalence of high serotonin uptake in lymphocytes of abstinent alcoholics
Faraj, B. A., Olkowski, Z. L., & Jackson, R. T. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00726-5 · Cited by 25
Souery, D., Lipp, O., Rivelli, S. K., Massat, I., Serretti, A., Cavallini, M. C., Ackenheil, M., Adolfsson, R., Aschauer, H. N., Blackwood, D., et al. (1999) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19991015)88:5 · Cited by 19
Sequence-Based Detection of Single Nucleotide Polymorphisms
Nickerson, D. A., Kolker, N., Taylor, S. L., & Rieder, M. J. (2003) · Humana Press eBooks · doi:10.1385/1-59259-235-x:029 · Cited by 15
Ca2+/Calmodulin and Protein Kinase C Regulation of Serotonin Transport in Human K562 Lymphocytes
Khan, N. A., Meyniel, J.-P., & Deschaux, P. (1996) · Cellular Immunology · doi:10.1006/cimm.1996.0242 · Cited by 13
Heikkinen, J., Pousi, B., Pope, M., & Myllyl�, R. (1999) · Human Mutation · doi:10.1002/(sici)1098-1004(199910)14:4 · Cited by 8
Flagged first, then by citations
3 of the 78 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Advances in autism genetics: on the threshold of a new neurobiology
Abrahams, B. S., & Geschwind, D. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2346 · Cited by 1,866
SLC6 Neurotransmitter Transporters: Structure, Function, and Regulation
Kristensen, A. S., Andersen, J., Jørgensen, T. N., Sørensen, L., Eriksen, J., Loland, C. J., Strømgaard, K., & Gether, U. (2011) · Pharmacological Reviews · doi:10.1124/pr.108.000869 · Cited by 874
Hoekstra, R. A., Bartels, M., Cath, D. C., & Boomsma, D. I. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0538-x · Cited by 651
The genetics of autistic disorders and its clinical relevance: a review of the literature
Freitag, C. M. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001896 · Cited by 638
Leekam, S. R., Prior, M. R., & Uljarevic, M. (2011) · Psychological Bulletin · doi:10.1037/a0023341 · Cited by 612
Metadata
- Authors
- Sutcliffe, J. S., Delahanty, R. J., Prasad, H. C., McCauley, J. L., Han, Q., Jiang, L., Li, C., Folstein, S. E., & Blakely, R. D.
- Affiliations
- Vanderbilt University (US)
- Johns Hopkins University (US)
- Corresponding author
- Sutcliffe, James S.
- Venue
- The American Journal of Human Genetics
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 77
- Issue
- 2
- Pages
- 265-279
- ISSN
- 0002-9297 (ISSN-L)
- PMC
- PMC1224529
- OpenAlex
- W2136328934
- Cited by
- 392
- References
- 78
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 10 · 2023: 13 · 2022: 6 · 2021: 17 · 2020: 15 · 2019: 10 · 2018: 15 · 2017: 16 · 2016: 18 · 2015: 16 · 2014: 20 · 2013: 22 · 2012: 27
- FWCI
- 18.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- The American Journal of Human Genetics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Vanderbilt Kennedy Center, Vanderbilt University Medical Center
- National Institute of Mental Health (R01MH061009, MH 61009, MH 64547, MH 55135, R01MH064547)
- National Institute on Drug Abuse (DA-07390, R01DA007390)
- National Center for Research Resources (M01RR000095, M01-RR-00095)
- NIH Clinical Center
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- autism spectrum disorder, serotonin transporter, allelic heterogeneity, 5-HTTLPR, chromosome 17q11.2, genetic linkage, rare alleles, candidate genes, platelet serotonin, 5-HT reuptake inhibitors
- MeSH terms
- Alanine, Alleles, Autistic Disorder, Blood Platelets, Chromosomes, Human, Pair 17, Compulsive Behavior, Exons, Family Health, Female, Genetic Markers, Glycine, Humans, Introns, Genetic Linkage, Male, Membrane Glycoproteins, Models, Genetic, Nerve Tissue Proteins, Pedigree, Phenotype, Polymorphism, Genetic, Risk, Serotonin, Time Factors, Linkage Disequilibrium, Gene Deletion, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
