Cited by 297Multiple Sclerosis Research StudiesGenetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.

A High-Density Screen for Linkage in Multiple Sclerosis

Open access

*·2005·The American Journal of Human Genetics

DOI 10.1086/444547PMC PMC1226210

Open this paper in CoChat — free account

Abstract

To provide a definitive linkage map for multiple sclerosis, we have genotyped the Illumina BeadArray linkage mapping panel (version 4) in a data set of 730 multiplex families of Northern European descent. After the application of stringent quality thresholds, data from 4,506 markers in 2,692 individuals were included in the analysis. Multipoint nonparametric linkage analysis revealed highly significant linkage in the major histocompatibility complex (MHC) on chromosome 6p21 (maximum LOD score [MLS] 11.66) and suggestive linkage on chromosomes 17q23 (MLS 2.45) and 5q33 (MLS 2.18). This set of markers achieved a mean information extraction of 79.3% across the genome, with a Mendelian inconsistency rate of only 0.002%. Stratification based on carriage of the multiple sclerosis-associated DRB1*1501 allele failed to identify any other region of linkage with genomewide significance. However, ordered-subset analysis suggested that there may be an additional locus on chromosome 19p13 that acts independent of the main MHC locus. These data illustrate the substantial increase in power that can be achieved with use of the latest tools emerging from the Human Genome Project and indicate that future attempts to systematically identify susceptibility genes for multiple sclerosis will have to involve large sample sizes and an association-based methodology.

Integrity signals

Registry

Crossref · 10.1086/444547

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Haploview: analysis and visualization of LD and haplotype maps
Barrett, J. C., Fry, B., Maller, J., & Daly, M. J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth457 · Cited by 14,551
New diagnostic criteria for multiple sclerosis: Guidelines for research protocols
Poser, C. M., Paty, D. W., Scheinberg, L., McDonald, W. I., Davis, F. A., Ebers, G. C., Johnson, K. P., Sibley, W. A., Silberberg, D. H., & Tourtellotte, W. W. (1983) · Annals of Neurology · doi:10.1002/ana.410130302 · Cited by 7,384
Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis
McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
The Future of Genetic Studies of Complex Human Diseases
Risch, N., & Merikangas, K. (1996) · Science · doi:10.1126/science.273.5281.1516 · Cited by 5,355
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
Lander, E. S., & Kruglyak, L. (1995) · Nature Genetics · doi:10.1038/ng1195-241 · Cited by 5,236
Merlin—rapid analysis of dense genetic maps using sparse gene flow trees
Abecasis, G. R., Cherny, S. S., Cookson, W., & Cardon, L. R. (2001) · Nature Genetics · doi:10.1038/ng786 · Cited by 3,323
Parametric and nonparametric linkage analysis: a unified multipoint approach.
Kruglyak, L., Daly, M. J., Daly, M. J., & Lander, E. S. (1996) · PubMed Central · Cited by 2,883
Complement factor H variant increases the risk of age-related macular degeneration
Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424
PedCheck: A Program for Identification of Genotype Incompatibilities in Linkage Analysis
O'Connell, J. R., & Weeks, D. E. (1998) · The American Journal of Human Genetics · doi:10.1086/301904 · Cited by 2,063

Flagged first, then by citations

Show all 69 references

Sorted by citations

Items 201–296 of 296

Autoimmune Disorders
Baranzini, S. E. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382227-7.00070-7 · Cited by 5
A single nucleotide polymorphism in the metabotropic glutamate receptor 7 gene is associated with multiple sclerosis in Iranian population
Mazdeh, M., Noroozi, R., Komaki‬, A., Azari, I., Ghafouri‐Fard, S., & Taheri, M. N. (2019) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2019.01.012 · Cited by 6
DIAGNOSIS AND DIFFERENTIAL DIAGNOSIS OF MULTIPLE SCLEROSIS
Cree, B. (2010) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000389932.38919.c7 · Cited by 6
Microsatellites and genome scans — A GAMES postscript
Dyment, D. A., & Ebers, G. C. (2007) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2007.07.011 · Cited by 6
Low frequency and rare coding variation contributes to multiple sclerosis riskPreprint
Mitrovič, M., Patsopoulos, N. A., Beecham, A. H., Dankowski, T., Goris, A., Dubois, B., D'hooghe, M. B., Lemmens, R., Damme, P. V., Fitzgerald, K., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/286617 · Cited by 6
High‐resolution HLA class II sequencing of Swedish multiple sclerosis patients
Akel, O., Zhao, L. P., Geraghty, D. E., & Lind, A. (2022) · International Journal of Immunogenetics · doi:10.1111/iji.12594 · Cited by 6
CD24 Gene Allele Variation Is Not Associated with Oligoclonal IgG Bands and IgG Index of Multiple Sclerosis Patients
Saadatnia, M., Najafi, M. R., Najafi, F., Davoudi, V., Keyhanian, K., & Maghzi, A. H. (2012) · NeuroImmunoModulation · doi:10.1159/000332011 · Cited by 5
Application of oligonucleotide arrays to high-content genetic analysis
Gibson, N. J. (2006) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.6.3.451 · Cited by 5
No association of leukemia inhibitory factor (LIF) DNA polymorphisms with multiple sclerosis
Vanderlocht, J., Burzykowski, T., Somers, V. A., Stinissen, P., & Hellings, N. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.09.016 · Cited by 5
From genes to characteristics of multiple sclerosis
Harbo, H. F., & Mero, I.-L. (2012) · Acta Neurologica Scandinavica · doi:10.1111/ane.12027 · Cited by 4
No evidence of IL21 association with multiple sclerosis in a Swedish population
Lindén, M., Nohra, R. G., Sundqvist, E., Khademi, M., Hillert, J. A., Alfredsson, L. S., Olsson, T. P., & Kockum, I. S. (2011) · Tissue Antigens · doi:10.1111/j.1399-0039.2011.01734.x · Cited by 4
Association of CD58 polymorphism and multiple sclerosis in Malaysia: a pilot study
Ching, Y. M., Viswanathan, S., Nor, N. M., Shuib, S., Kamarudin, B., Mansor, S., Yusof, A. Y., & Arip, M. (2019) · Autoimmunity Highlights · doi:10.1186/s13317-019-0123-7 · Cited by 4
The Potential of Human Amnion Epithelial Cells as an Immunomodulatory and Neuroregenerative Treatment for Multiple Sclerosis
McDonald, C., Short, M. A., Jenkin, G., & Bernard, C. C. A. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1118-9_21 · Cited by 4
Epidemiology and Genetics
Roostaei, T., & Jager, P. L. D. (2019) · Current clinical neurology · doi:10.1007/978-3-030-24436-1_4 · Cited by 4
DNA methylation signatures of Multiple Sclerosis occur independently of genetic risk and are primarily attributed to B cells and monocytesPreprint
Xavier, A., Maltby, V. E., Ewing, E., Campagna, M. P., Burnard, S. M., Tegner, J. N., Slee, M., Butzkueven, H., Kockum, I. S., Kular, L., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2570500/v1 · Cited by 4
Genetic variation in the human leukocyte antigen region confers susceptibility to Clostridioides difficile infection
Ferar, K., Hall, T. O., Crawford, D. C., Rowley, R. K., Satterfield, B. A., Li, R., Gragert, L. A., Karlson, E. W., de Andrade, M., Kullo, I. J., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-45649-4 · Cited by 3
Ofatumumab: A Novel Anti-CD20 Monoclonal Antibody for Multiple Sclerosis: A Review of Clinical Considerations
Barham, W. T., Dillman, K. M., Hebert, J. D., Kerut, C. K., Klapper, R. J., Ahmadzadeh, S., Shekoohi, S., Cornett, E. M., & Kaye, A. D. (2024) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-024-01649-7 · Cited by 3
Multiple Sclerosis: Clinical Features, Immunopathogenesis, and Treatment
Lizarraga, A., & Sheremata, W. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-51220-4_2 · Cited by 3
Role of Genetic Factors in Pathophysiology of Multiple Sclerosis
Goris, A., Dubois, B., & Hilven, K. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800763-1.00008-7 · Cited by 3
Multiple Sclerosis
Reynolds, R., & Crichton, R. R. (2013) · Royal Society of Chemistry eBooks · doi:10.1039/9781849735896-00163 · Cited by 3
Susceptibility to experimental autoimmune encephalomyelitis (model of multiple sclerosis) and anxiety in genetically heterogeneous rats
Martínez-Membrives, E. (2012) · TDX (Tesis Doctorals en Xarxa) · Cited by 3
Could vitamin D be the answer to multiple sclerosis?
Broadley, S. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458507078683 · Cited by 3
Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families
Ramagopalan, S. V., Morrison, K., Para, A. E., Handel, A. E., Disanto, G., Handunnetthi, L., Orton, S. M., Sadovnick, A. D., & Ebers, G. C. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.04.017 · Cited by 2
Role of T and B cells in pathogenesis of multiple sclerosis
Pavelek, Z., Krejsek, J., & Vališ, M. (2016) · Neurologie pro praxi · doi:10.36290/neu.2016.020 · Cited by 2
Sp3 ameliorated experimental autoimmune encephalomyelitis by triggering Socs3 in Th17 cells
Li, Y., Zhu, M., Yang, P., Chen, D., Zhou, D., Ren, Y., Zhang, Z., Ruan, C., Da, Y., & Zhang, R. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.01.051 · Cited by 2
Adenosine and Multiple Sclerosis
Sánchez‐Gómez, M. V., González‐Fernández, E., Arellano, R. O., & Matute, C. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3903-5_21 · Cited by 2
UNCOVERING THE GENETIC ARCHITECTURE OF MULTIPLE SCLEROSIS
Esposito, F., & Jager, P. L. D. (2010) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000389939.15155.eb · Cited by 2
NOS2A as a candidate gene in Relapsing–Remitting Multiple Sclerosis: A haplotype study using selected subsets of single nucleotide polymorphisms
Manna, I., Liguori, M., Valentino, P., Vena, L., Condino, F., Nisticò, R., Palma, G. D., Quattrone, A., & Gambardella, A. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.02.008 · Cited by 2
Genetics in multiple sclerosis: past and future perspectives
Harbo, H. F., & Spurkland, A. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2007.00843.x · Cited by 2
Collaboration in Translational Neuroscience: A Call to Arms
Ivinson, A. J. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.036 · Cited by 2
Lymphocyte populations and their change during five-year glatiramer acetate treatment
Pavelek, Z., Vyšata, O., Sobíšek, L., Klímová, B., Andrýs, C., Vokurková, D., Mazurová, R., Štourač, P., & Vališ, M. (2018) · Neurologia i Neurochirurgia Polska · doi:10.1016/j.pjnns.2018.08.001 · Cited by 2
23rd Nantes Actualités Transplantation: “Genomics and Immunogenetics of Kidney and Inflammatory Diseases—Lessons for Transplantation”
Vince, N., Poschmann, J., Josien, R., Anegón, I., Limou, S., & Gourraud, P. (2018) · Transplantation · doi:10.1097/tp.0000000000002517 · Cited by 2
Genetics of Multiple Sclerosis
Alcina, A., Fedetz, M., & Matesanz, F. (2019) · Rare diseases of the immune system · doi:10.1007/978-3-030-03934-9_10 · Cited by 2
Multiple Sclerosis
Houtchens, M. K., & Khoury, S. J. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-384978-6.00052-2 · Cited by 2
Epidemiology and Genetics
Jager, P. L. D. (2012) · Wiley eBooks · doi:10.1002/9781119963714.ch3 · Cited by 2
Evidence for a complex interaction between HLA-DRB1 and environmental factors in MS
Fontaine, B., & Barcellos, L. F. (2008) · Neurology · doi:10.1212/01.wnl.0000296821.72466.d3 · Cited by 2
From the Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
Wadman, C. (2007) · Cited by 2
Multiple Sclerosis
Quintana, F. J., & Weiner, H. L. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382227-7.00072-0 · Cited by 1
Genetic Risk in Multiple Sclerosis: Susceptibility, Modifiers and Unresolved Questions
He, J., Blackburn, N. B., & Jokubaitis, V. (2026) · Neurology and Therapy · doi:10.1007/s40120-026-01009-8 · Cited by 1
Genetic and Environmental Risk Factors for Multiple Sclerosis—A Role for Interaction Analysis
Kockum, I. S., Alfredsson, L. S., & Olsson, T. P. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397017-6.00006-4 · Cited by 2
OCTN genes: Susceptibility genes for autoimmune diseases?
Urcelay, E., de la Concha, E. G., & Martínez, A. (2007) · Inmunología · doi:10.1016/s0213-9626(07)70078-1 · Cited by 1
MEDICAL MANAGEMENT AND PHARMACOLOGY UPDATE
Epstein, J. B., Raber‐Durlacher, J. E., Chavarria, M.-G., & Myint, H. (2009) · Cited by 1
Just in Time: An Update on Continuum Neurogenetics
Rost, N. S. (2011) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000396959.52198.1b · Cited by 1
Monitoring of Lymphocyte Populations During Treatment with Interferon-β-1b to Predict Multiple Sclerosis Disability Progression
Vališ, M., Vyšata, O., Sobíšek, L., Klímová, B., Andrýs, C., Vokurková, D., & Pavelek, Z. (2018) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2018.0100 · Cited by 1
ASSOCIAÇÃO ENTRE MICROBIOTA INTESTINAL E DOENÇAS AUTOIMUNES: UMA ANÁLISE COM ÊNFASE NA ESCLEROSE MÚLTIPLA
Reis, M. F., Nascimento, J. V. P., de Carvalho, L. I., de Carvalho, D. C., Tironi, T. D. S., & Perobelli, S. M. (2022) · Revista Educação e Saúde fundamentos e desafios · doi:10.29327/2192205.2.3-8 · Cited by 14
Multiple Sklerose und andere autoimmune ZNS-Erkrankungen
Kroner, A., Kleinschnitz, C., Stadelmann, C., Raab, P., Stangel, M., Trebst, C., Voß, E. V., & Cordes, A.-L. (2011) · Springer eBooks · doi:10.1007/978-3-642-20477-7_1 · Cited by 1
Genetics of multiple sclerosis today
Sokolova, E. А., Boyarskikh, U. A., Aulchenko, Y. S., & Филипенко, М. Л. (2016) · Biology Bulletin Reviews · doi:10.1134/s2079086416020080 · Cited by 1
Potencjalne czynniki patogenne w stwardnieniu rozsianym (SM) Potential pathogens in multiple sclerosis (MS)
Zawada, M. (2012) · Cited by 1
Introduction
Cohen, J. A., & Rae-Grant, A. D. (2012) · doi:10.1007/978-1-907673-50-4_1 · Cited by 1
Genética de la esclerosis múltiple: papel del HLA-DRB1 en la susceptibilidad y expresión fenotípica
Pinel, R., & María, L. (2010) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) · Cited by 1
Genetic Variation and Expression of the IRF5 Gene in Autoimmune Diseases
Kristjansdottir, G. (2009) · Opin vísindi (Opin vísindi) · Cited by 1
GENETIC ANALYSIS OF IL7R AND OTHER IMMUNE- REGULATORY GENES IN MULTIPLE SCLEROSIS
Lundmark, F. (2007) · Figshare · Cited by 1
Linkage disequilibrium analyses within chromosome 19p in multiple sclerosis
Vyshkina, T., & Kálmán, B. (2008) · Multiple Sclerosis Journal · doi:10.1177/1352458507084267 · Cited by 1
A follow-up study of Nordic multiple sclerosis candidate gene regions
Datta, P., Harbo, H. F., Ryder, L. P., Åkesson, E., Benedikz, J. E. G., Celius, E. G., Andersen, O., Myhr, K., Sandberg‐Wollheim, M., Hillert, J. A., et al. (2007) · Multiple Sclerosis Journal · doi:10.1177/1352458506071790 · Cited by 1
Multiple sclerosis in Asian populations : the genetic and environmental determinants of variable susceptibility and clinical profile
Lee, J. D. (2014) · cIRcle (University of British Columbia) · doi:10.14288/1.0165922 · Cited by 1
Untitled work
(2017) · doi:10.1101/061366 · Cited by 1
Novel Multiple Sclerosis Predisposing Genetic Variants Outside the HLA Region
Kallio, S. (2009) · Työväentutkimus Vuosikirja · Cited by 1
Immunopathogenesis of Multiple Sclerosis: Overview
Menge, T., Hemmer, B., Nessler, S., Zhou, D., Kieseier, B. C., & Hartung, H. (2007) · Springer eBooks · doi:10.1007/978-0-387-36003-4_10
Studies on causes of multiple sclerosis : From genes to transcriptome
Kemppinen, A. (2011) · Työväentutkimus Vuosikirja
Imaging patterns of inflammation in multiple sclerosis: a multifocal approach
Vellinga, M. M. (2009) · Pure Amsterdam UMC
Genetic analysis of chromosomal regions 2q33, 7q32 and 19q13 in multiple sclerosis susceptibility
Bonetti, A. (2009) · Työväentutkimus Vuosikirja
Relação entre funções cognitivas e perdas adquiridas na visão de cores de pacientes com esclerose múltipla tipo remitente recorrente
Teixeira, R. A. A. (2012) · doi:10.11606/t.47.2012.tde-05122012-151814
Cytogenetic effects of combination of tridecactide and met-enkephalin on lymphocytes of patients with multiple sclerosis
Rakanović-Todić, M., Ibrulj, S., Burnazović-Ristić, L., Ćatović, A., Aganović-Mušinović, I., & Kusturica, J. (2015) · Journal of Health Sciences · doi:10.17532/jhsci.2015.237
Investigating the role of Th17 cells in the initiation and chronification of autoimmune CNS demyelination
Paterka, M. (2013) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-8598
Genetic and Immunological Mechanisms Regulating Neuroinflammation
Gillett, A. (2010) · Figshare
Heterogeneity in multiple sclerosis; a bio-marker approach
Zwemmer, J. (2011) · Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam)
Genetic variations influencing susceptibility to multiple sclerosis
Duvefelt, K. (2005) · Figshare
Investigation of genetic factors in multiple sclerosis
Bomfim, I. L. (2009) · Figshare
Blood and CSF biomarkers for investigation of the immunopathogenesis of relapse in Multiple Sclerosis
Malmeström, C. (2008) · Gothenburg University Publications Electronic Archive (Gothenburg University)
The Genetics of Multiple Sclerosis and Neuromyelitis Optica in Japan
Yoshimura, S. (2014)
Investigating the potential regulation of Asic2 by microRNAs
Cole, H. R. (2012) · UEA Digital Repository (University of East Anglia)
Neutralizing antibodies and the biological response to interferon-beta therapy
Lam, S. M. (2010) · cIRcle (University of British Columbia) · doi:10.14288/1.0071071
Advance of genetics in multiple sclerosis
Matsushita, T. (2015) · Clinical and Experimental Neuroimmunology · doi:10.1111/cen3.12275
Gene Expression and Variation in Multiple Sclerosis
Szvetko, A. L. (2009) · Griffith Research Online · doi:10.25904/1912/1563
High-Throughput Mutation Screening Using a Single Amplification Condition
Shi, L., & Landers, J. E. (2009) · Methods in molecular biology · doi:10.1007/978-1-60327-811-9_14
Genetic and Immunological Dissection of Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
Nohra, R. G. (2009)
Immunologyof MS
Fletcher, J. M., & Mills, K. H. G. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511979088.005
CHAPTER 85 – “Omics” in the Study of Multiple Sclerosis
Quintana, F., & Weiner, H. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-369420-1.00085-8
Genomic Evaluation of Multiple Sclerosis
Quintana, F. J., & Weiner, H. L. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374934-5.00044-1
Quantifying environmental risk factors for multiple sclerosis in discordant monozygotic twins: A case report
Zahednasab, H., Jabalameli, M. R., Bahreini, S. A., & Ashtari, F. (2015) · Acta Medica International · doi:10.5530/ami.2015.5.2
The role of activated microglia in multiple sclerosis and clinically isolated syndromes: neuroimaging studies
Giannetti, P. (2015) · Spiral (Imperial College London) · doi:10.25560/34680
Gateway Reflexes Are Stimulated by Neural Activations and Promote the Pathogenesis of Multiple Sclerosis Models
Higuchi, K., Kamimura, D., Štofková, A., Nishikawa, N., Ohki, T., Arima, Y., & Murakami, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805298-3.00005-0
Rendimientos cognitivos en una muestra de pacientes con Esclerosis Múltiple en Navarra. Variables asociadas
Mingueza, A. M. A. (2017) · doi:10.14201/gredos.151014
Uncovering the Genetic Architecture of Multiple Sclerosis
Jager, P. L. D., & Hafler, D. A. (2009) · Blue books of neurology · doi:10.1016/b978-1-4160-6068-0.00003-6
White Matter Damage in Multiple Sclerosis
Sánchez‐Gómez, M. V., Pérez‐Cerdá, F., & Matute, C. (2013) · Springer eBooks · doi:10.1007/978-1-4614-9123-1_17
References
(2006) · Elsevier eBooks · doi:10.1016/b978-0-443-07271-0.50022-7
Multiple sclerosis
Sandrock, A. W., & Rudick, R. A. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9780511980053.011
Epidemiology and genetics of multiple sclerosis
Rous, M. (2023) · Neurologie pro praxi · doi:10.36290/neu.2023.055
Association of CD58 rs12044852 and rs2300747 polymorphisms with the risk of multiple sclerosis: A systematic review and meta-analysis
Ahmed, A., Rawshan, A. E. M., Tishe, Z. H., Shawkat, S., Popy, M. N., Shohag, M. H., Hossain, M., & Mostaid, M. S. (2023) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2023.105411
Microglial glutathione and glutamate: regulation mechanisms
Fry, V. A. H. (2009) · UCL Discovery (University College London)
HLA Genotyping in Patients with Multiple Sclerosis and Insulin-Dependent Diabetic Patients: Descriptive Study in A Multiplex Libyan Families
Tabagh, R. M. (2025) · AlQalam Journal of Medical and Applied Sciences · doi:10.54361/ajmas.258220
CXCL13: A Prognostic Marker in Multiple Sclerosis
Havervall, C. (2010) · Diva portal (Dalarna University Library)
Multiple sclerosis and pregnancy: pregnancy, delivery and birth outcome in woman with multiple sclerosis
Dahl, J. (2008) · NORA - Norwegian Open Research Archives
Depression, Fatigue, Declines in Cognitive Function and Uncertainty in Women with Multiple Sclerosis
Gray, C. L. (2014) · UA Campus Repository (The University of Arizona)
Multiple sclerosis
Khayat-Khoei, M., Houtchens, M. K., & Khoury, S. J. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45863-7.00078-0
Two Years of Ocrelizumab Treatment in Black and Hispanic People with Multiple Sclerosis in CHIMES : A Single‐Arm Clinical Trial
Amezcua, L., Reder, A. T., Bernitsas, E., Monson, N. L., Vartanian, T. K., Wu, G. F., Saleh, M. N., Okai, A. F., Obeidat, A. Z., Sokhi, D., et al. (2026) · Annals of Neurology · doi:10.1002/ana.78290

Authors: *
Affiliations: University of Cambridge (GB)
Corresponding author: *
Venue: The American Journal of Human Genetics
Publisher: Elsevier BV
Published: 2005-09
Volume: 77
Issue: 3
Pages: 454-467
ISSN: 0002-9297 (ISSN-L)
DOI: 10.1086/444547
PMC: PMC1226210
OpenAlex: W114001912
Cited by: 297
References: 69
Citations by year: 2026: 3 · 2025: 3 · 2024: 2 · 2023: 10 · 2022: 8 · 2021: 2 · 2020: 3 · 2019: 7 · 2018: 11 · 2017: 5 · 2016: 10 · 2015: 9 · 2014: 12 · 2013: 9 · 2012: 25
FWCI: 23.99
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2878 d)
Locations: The American Journal of Human Genetics (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Multiple Sclerosis Society
Wellcome Trust
National Institutes of Health
National Institute of Allergy and Infectious Diseases (P01AI065687, U19AI067152)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK064869, U01DK062432)
National Institute of Neurological Disorders and Stroke (NS032830, R01NS032830)
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Keywords: multiple sclerosis, genetic linkage, high-density genotyping, major histocompatibility complex, chromosome 6p21, chromosome 19p13, multiplex families, susceptibility genes
MeSH terms: Australia, Chromosome Mapping, Chromosomes, Human, Europe, Family, Genetic Markers, Genetic Testing, Humans, Genetic Linkage, Middle Aged, Multiple Sclerosis, United States, Genetic Predisposition to Disease, Genomics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A High-Density Screen for Linkage in Multiple Sclerosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks