A High-Density Screen for Linkage in Multiple Sclerosis

Haploview: analysis and visualization of LD and haplotype maps

Barrett, J. C., Fry, B., Maller, J., & Daly, M. J. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth457 · Cited by 14,551

New diagnostic criteria for multiple sclerosis: Guidelines for research protocols

Poser, C. M., Paty, D. W., Scheinberg, L., McDonald, W. I., Davis, F. A., Ebers, G. C., Johnson, K. P., Sibley, W. A., Silberberg, D. H., & Tourtellotte, W. W. (1983) · Annals of Neurology · doi:10.1002/ana.410130302 · Cited by 7,384

Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis

McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591

The Future of Genetic Studies of Complex Human Diseases

Risch, N., & Merikangas, K. (1996) · Science · doi:10.1126/science.273.5281.1516 · Cited by 5,355

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

Lander, E. S., & Kruglyak, L. (1995) · Nature Genetics · doi:10.1038/ng1195-241 · Cited by 5,236

Merlin—rapid analysis of dense genetic maps using sparse gene flow trees

Abecasis, G. R., Cherny, S. S., Cookson, W., & Cardon, L. R. (2001) · Nature Genetics · doi:10.1038/ng786 · Cited by 3,323

Parametric and nonparametric linkage analysis: a unified multipoint approach.

Kruglyak, L., Daly, M. J., Daly, M. J., & Lander, E. S. (1996) · PubMed Central · Cited by 2,883

Complement factor H variant increases the risk of age-related macular degeneration

Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424

PedCheck: A Program for Identification of Genotype Incompatibilities in Linkage Analysis

O'Connell, J. R., & Weeks, D. E. (1998) · The American Journal of Human Genetics · doi:10.1086/301904 · Cited by 2,063

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

The International Multiple Sclerosis Genetics Consortium & The Wellcome Trust Case Control Consortium 2 (2011) · Nature · doi:10.1038/nature10251 · Cited by 2,697

Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

(2007) · New England Journal of Medicine · doi:10.1056/nejmoa073493 · Cited by 1,746

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

Fletcher, J. M., Lalor, S. J., Sweeney, C. M., Tubridy, N. J., & Mills, K. H. G. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04143.x · Cited by 975

Multiple Sclerosis: Mechanisms and Immunotherapy

Baecher-Allan, C., Kaskow, B. J., & Weiner, H. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.021 · Cited by 938

The Neurobiology of Multiple Sclerosis: Genes, Inflammation, and Neurodegeneration

Hauser, S. L., & Oksenberg, J. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.011 · Cited by 793

Multiple sclerosis

Nylander, A., & Hafler, D. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58649 · Cited by 495

Variation in interleukin 7 receptor α chain (IL7R) influences risk of multiple sclerosis

Lundmark, F., Duvefelt, K., Iacobaeus, E., Kockum, I., Wallström, E., Khademi, M., Oturai, A., Ryder, L. P., Saarela, J., Harbo, H. F., et al. (2007) · Nature Genetics · doi:10.1038/ng2106 · Cited by 483

Class II HLA interactions modulate genetic risk for multiple sclerosis

the International Multiple Sclerosis Genetics Consortium (2015) · Nature Genetics · doi:10.1038/ng.3395 · Cited by 418

Multiple sclerosis genetics

Sawcer, S. J., Franklin, R. J. M., & Ban, M. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70041-9 · Cited by 432

The genetics of multiple sclerosis: SNPs to pathways to pathogenesis

Oksenberg, J. R., Baranzini, S. E., Sawcer, S., & Hauser, S. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2395 · Cited by 347

B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers

van Langelaar, J., Rijvers, L., Smolders, J., & van Luijn, M. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00760 · Cited by 343

Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis

Barcellos, L. F., Sawcer, S. J., Ramsay, P. P., Baranzini, S. E., Thomson, G. J., Briggs, F. B. S., Cree, B., Begovich, A. B., Villoslada, P., Montalbán, X., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl223 · Cited by 312

Effector T Cells in Multiple SclerosisPreprint

Kaskow, B. J., & Baecher‐Allan, C. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029025 · Cited by 335

The genetics of multiple sclerosis: an up‐to‐date review

Gourraud, P., Harbo, H. F., Hauser, S. L., & Baranzini, S. E. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01134.x · Cited by 294

Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis

Hedström, A. K., Sundqvist, E., Bäärnhielm, M., Nordin, N. S., Hillert, J. A., Kockum, I. S., Olsson, T. P., & Alfredsson, L. S. (2011) · Brain · doi:10.1093/brain/awq371 · Cited by 279

A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility

Reich, D., Patterson, N. J., Jager, P. L. D., McDonald, G. J., Waliszewska, A., Tandon, A., Lincoln, R., DeLoa, C., Fruhan, S. A., Cabre, P., et al. (2005) · Nature Genetics · doi:10.1038/ng1646 · Cited by 269

The Genetics of Multiple Sclerosis: From 0 to 200 in 50 Years

Baranzini, S. E., & Oksenberg, J. R. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.09.004 · Cited by 264

HLA-A Confers an HLA-DRB1 Independent Influence on the Risk of Multiple Sclerosis

Brynedal, B., Duvefelt, K., Jonasdottir, G., Roos, I. M., Åkesson, E., Palmgren, J., & Hillert, J. A. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000664 · Cited by 202

Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study

Barcellos, L. F., Kamdar, B. B., Ramsay, P. P., DeLoa, C., Lincoln, R., Caillier, S. J., Schmidt, S., Haines, J. L., Pericak‐Vance, M. A., Oksenberg, J. R., et al. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70552-x · Cited by 205

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

Friese, M. A., Jakobsen, K. B., Friis, L. S., Etzensperger, R., Craner, M. J., McMahon, R. M., Jensen, L. T., Huygelen, V., Jones, E. Y., Bell, J. I., et al. (2008) · Nature Medicine · doi:10.1038/nm.1881 · Cited by 184

Integrating risk factors

Jager, P. L. D., Simon, K. C., Munger, K. L., Rioux, J. D., Hafler, D. A., & Ascherio, A. (2008) · Neurology · doi:10.1212/01.wnl.0000294325.63006.f8 · Cited by 179

Genotype–Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures

Okuda, D. T., Srinivasan, R., Oksenberg, J. R., Goodin, D. S., Baranzini, S. E., Beheshtian, A., Waubant, E. L., Zamvil, S. S., Leppert, D., Qualley, P., et al. (2008) · Brain · doi:10.1093/brain/awn301 · Cited by 175

A second major histocompatibility complex susceptibility locus for multiple sclerosis

Yeo, T. W., Jager, P. L. D., Gregory, S. G., Barcellos, L. F., Walton, A., Goris, A., Fenoglio, C., Ban, M., Taylor, C. J., Goodman, R. S., et al. (2007) · Annals of Neurology · doi:10.1002/ana.21063 · Cited by 175

Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk

Mitrovič, M., Patsopoulos, N. A., Beecham, A. H., Dankowski, T., Goris, A., Dubois, B., D'hooghe, M. B., Lemmens, R., Damme, P. V., Søndergaard, H. B., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.049 · Cited by 179

Pathogenic CD8+ T cells in multiple sclerosis

Friese, M. A., & Fugger, L. H. (2009) · Annals of Neurology · doi:10.1002/ana.21744 · Cited by 170

Multiple sclerosis: the environment and causation

Giovannoni, G., & Ebers, G. C. (2007) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32815610c2 · Cited by 169

Evidence for Polygenic Susceptibility to Multiple Sclerosis—The Shape of Things to Come

The International Multiple Sclerosis Genetics Consortium (IMSGC) (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.02.027 · Cited by 167

Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?

Mayne, K., White, J. A., McMurran, C. E., Rivera, F. J., & de la Fuente, A. G. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.572090 · Cited by 167

Advances in the immunopathogenesis of multiple sclerosis

Yadav, S. K., Mindur, J. E., Ito, K., & Dhib-Jalbut, S. S. (2015) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000205 · Cited by 173

Epidemiology and natural history of multiple sclerosis: new insights

Kantarci, O., & Wingerchuk, D. (2006) · Current Opinion in Neurology · doi:10.1097/01.wco.0000227033.47458.82 · Cited by 156

Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations

Kristjansdottir, G., Sandling, J. K., Bonetti, A., Roos, I. M., Milani, L. A., Wang, C., Gustafsdottir, S., Sigurðsson, S., Lundmark, A., Tienari, P. J., et al. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2007.055012 · Cited by 151

FTY720 Rescue Therapy in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis: Expression of Central Nervous System Genes and Reversal of Blood‐Brain‐Barrier Damage

Foster, C. A., Mechtcheriakova, D., Storch, M. K., Balatoni, B., Howard, L. M., Bornancin, F., Wlachos, A., Sobanov, J., Kinnunen, A., & Baumruker, T. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2008.00182.x · Cited by 143

Multiple sclerosis genetics—is the glass half full, or half empty?

Oksenberg, J. R., & Baranzini, S. E. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.91 · Cited by 138

Pathophysiology of multiple sclerosis

Korn, T. (2008) · Journal of Neurology · doi:10.1007/s00415-008-6001-2 · Cited by 147

High-density SNP analysis of 642 Caucasian families with rheumatoid arthritis identifies two new linkage regions on 11p12 and 2q33

Amos, C. I., Chen, W. V., Lee, A., Li, W., Kern, M., Lundsten, R., Batliwalla, F., Wener, M. H., Remmers, E. F., Kastner, D. L., et al. (2006) · Genes and Immunity · doi:10.1038/sj.gene.6364295 · Cited by 132

Using high-throughput SNP technologies to study cancer

Engle, L. J., Simpson, C. L., & Landers, J. E. (2006) · Oncogene · doi:10.1038/sj.onc.1209368 · Cited by 128

Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor

Ban, M., Goris, A., Lorentzen, Å. R., Baker, A., Mihalova, T., Ingram, G., Booth, D. R., Heard, R. N., Stewart, G. J., Bogaert, E., et al. (2009) · European Journal of Human Genetics · doi:10.1038/ejhg.2009.41 · Cited by 128

The complex genetics of multiple sclerosis: pitfalls and prospects

Sawcer, S. J. (2008) · Brain · doi:10.1093/brain/awn081 · Cited by 117

Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA

Cree, B., Reich, D., Khan, O. A., Jager, P. L. D., Nakashima, I., Takahashi, T., Bar‐Or, A., Tong, C., Hauser, S. L., & Oksenberg, J. R. (2009) · Archives of Neurology · doi:10.1001/archneurol.2008.541 · Cited by 113

Complement in multiple sclerosis: its role in disease and potential as a biomarker

Ingram, G., Hakobyan, S. A., Robertson, N. P., & Morgan, B. P. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03830.x · Cited by 112

Genetics of multiple sclerosis: lessons from polygenicity

Goris, A., Vandebergh, M., McCauley, J. L., Saarela, J., & Cotsapas, C. J. (2022) · The Lancet Neurology · doi:10.1016/s1474-4422(22)00255-1 · Cited by 116

Genetics and pathogenesis of multiple sclerosis

Zuvich, R. L., McCauley, J. L., Pericak‐Vance, M. A., & Haines, J. L. (2009) · Seminars in Immunology · doi:10.1016/j.smim.2009.08.003 · Cited by 98

Interrogating the major histocompatibility complex with high-throughput genomics

de Bakker, P. I. W., & Raychaudhuri, S. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds384 · Cited by 95

A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches

Bashinskaya, V. V., Кулакова, О. Г., Boyko, A. N., Favorov, A. V., & Favorova, O. O. (2015) · Human Genetics · doi:10.1007/s00439-015-1601-2 · Cited by 102

APOE epsilon variation in multiple sclerosis susceptibility and disease severity

Burwick, R. M., Ramsay, P. P., Haines, J. L., Hauser, S. L., Oksenberg, J. R., Pericak‐Vance, M. A., Schmidt, S., Compston, A., Sawcer, S. J., Cittadella, R., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000210531.19498.3f · Cited by 90

Genome‐wide association studies of multiple sclerosis

Cotsapas, C., & Mitrovic, M. (2018) · Clinical & Translational Immunology · doi:10.1002/cti2.1018 · Cited by 89

The Immunogenetic Architecture of Autoimmune DiseasePreprint

Goris, A., & Liston, A. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007260 · Cited by 96

Cortical Demyelination Can Be Modeled in Specific Rat Models of Autoimmune Encephalomyelitis and Is Major Histocompatability Complex (MHC) Haplotype-Related

Storch, M., Bauer, J., Linington, C., Olsson, T., Weissert, R., & Lassmann, H. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000248547.13176.9d · Cited by 90

Large scale single nucleotide polymorphism discovery in unsequenced genomes using second generation high throughput sequencing technology: applied to turkey

Kerstens, H. H. D., Crooijmans, R. P. M. A., Veenendaal, A., Dibbits, B. W., Chin‐A‐Woeng, T. F. C., den Dunnen, J. T., & Groenen, M. A. M. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-479 · Cited by 87

Multiple sclerosis

Cotsapas, C. J., Mitrovič, M., & Hafler, D. A. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64076-5.00046-6 · Cited by 88

Efficacy and Safety of the Newer Multiple Sclerosis Drugs Approved Since 2010

Faissner, S., & Gold, R. (2018) · CNS Drugs · doi:10.1007/s40263-018-0488-6 · Cited by 78

Multiple sclerosis genetics

Cantó, E., & Oksenberg, J. R. (2018) · Multiple Sclerosis Journal · doi:10.1177/1352458517737371 · Cited by 89

The impact of HLA‐A and ‐DRB1 on age at onset, disease course and severity in Scandinavian multiple sclerosis patients

Smestad, C., Brynedal, B., Jonasdottir, G., Lorentzen, Å. R., Masterman, T., Åkesson, E., Spurkland, A., Lie, B. A., Palmgren, J., Celius, E. G., et al. (2007) · European Journal of Neurology · doi:10.1111/j.1468-1331.2007.01825.x · Cited by 75

A population‐based study of coeliac disease, neurodegenerative and neuroinflammatory diseases

Ludvigsson, J. F., Olsson, T. P., Ekbom, A., & Montgomery, S. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03329.x · Cited by 71

Immunology Taught by Human GeneticsPreprint

Casanova, J., Abel, L., & Quintana‐Murci, L. (2013) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2013.78.019968 · Cited by 77

Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis

McKay, F. C., Swain, L. I., Schibeci, S. D., Rubio, J. P., Kilpatrick, T. J., Heard, R. N., Stewart, G. J., & Booth, D. R. (2007) · Genes and Immunity · doi:10.1038/sj.gene.6364436 · Cited by 68

A Major Histocompatibility Class I Locus Contributes to Multiple Sclerosis Susceptibility Independently from HLA-DRB1*15:01

Cree, B., Rioux, J. D., McCauley, J. L., Gourraud, P., Goyette, P., McElroy, J. P., Jager, P. L. D., Santaniello, A., Vyse, T. J., Gregersen, P. K., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011296 · Cited by 66

Genes implicated in multiple sclerosis pathogenesis from consilience of genotyping and expression profiles in relapse and remission

Arthur, A., Armati, P. J., Bye, C., Heard, R., Stewart, G. J., Pollard, J., Booth, D. R., & S. Consortium (2008) · BMC Medical Genetics · doi:10.1186/1471-2350-9-17 · Cited by 180

A Role for VAV1 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis

Jagodic, M., Colacios, C., Nohra, R. G., Dejean, A. S., Beyeen, A. D., Khademi, M., Casemayou, A., Lamouroux, L., Duthoit, C. T., Papapietro, O., et al. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000278 · Cited by 66

Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility

Zuvich, R. L., McCauley, J. L., Oksenberg, J. R., Sawcer, S. J., Jager, P. L. D., Aubin, C., Cross, A. H., Piccio, L. M., Aggarwal, N. T., Evans, D. A., et al. (2010) · Human Genetics · doi:10.1007/s00439-010-0789-4 · Cited by 65

European Charcot Foundation Lecture: The natural history of multiple sclerosis and gender

Sadovnick, A. D. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.09.005 · Cited by 61

PRKCA and Multiple Sclerosis: Association in Two Independent Populations

Saarela, J., Kallio, S. P., Chen, D., Montpetit, A., Jokiaho, A. J., Choi, E., Asselta, R., Bronnikov, D., Lincoln, M. R., Sadovnick, A. D., et al. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020042 · Cited by 60

Risk alleles for multiple sclerosis in multiplex families

D’Netto, M. J., Ward, H., Morrison, K., Ramagopalan, S. V., Dyment, D. A., DeLuca, G. C., Handunnetthi, L., Sadovnick, A. D., & Ebers, G. C. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a92c25 · Cited by 62

Multiple sclerosis genetics

Cree, B. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52001-2.00009-1 · Cited by 62

Role of the MHC2TA gene in autoimmune diseases

Martínez, A., Sánchez-López, M., Varadé, J., Mas, A. I. R., Martín, M. C., Heras, V. D. L., Arroyo, R., Mendoza, J. L., Díaz‐Rubio, M., Fernández‐Gutiérrez, B., et al. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.059428 · Cited by 60

Revealing the genetic basis of multiple sclerosis: are we there yet?

Baranzini, S. E. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.12.006 · Cited by 58

What role for genetics in the prediction of multiple sclerosis?

Sawcer, S. J., Ban, M., Wason, J. M. S., & Dudbridge, F. (2009) · Annals of Neurology · doi:10.1002/ana.21911 · Cited by 55

Multifactor dimensionality reduction reveals gene–gene interactions associated with multiple sclerosis susceptibility in African Americans

Brassat, D., Motsinger, A. A., Caillier, S., Erlich, H., Walker, K., Steiner, L., Cree, B., Barcellos, L., Pericak-Vance, M., Schmidt, S., et al. (2006) · Genes and Immunity · doi:10.1038/sj.gene.6364299 · Cited by 54

An update on the use of cerebrospinal fluid analysis as a diagnostic tool in multiple sclerosis

Gastaldi, M., Zardini, E., & Franciotta, D. M. (2016) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2017.1262260 · Cited by 54

The interplay between T helper cells and brain barriers in the pathogenesis of multiple sclerosis

Angelini, G., Bani, A., Constantin, G., & Rossi, B. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1101379 · Cited by 57

CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis

Bronson, P. G., Caillier, S. J., Ramsay, P. P., McCauley, J. L., Zuvich, R. L., Jager, P. L. D., Rioux, J. D., Ivinson, A. J., Compston, A., Hafler, D. A., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq101 · Cited by 52

Heterogeneity at the HLA-DRB1 allelic variation locus does not influence multiple sclerosis disease severity, brain atrophy or cognition

van der Walt, A., Stankovich, J. M., Bahlo, M., Taylor, B. V., van der Mei, I. A. F., Foote, S. J., Rubio, J. P., Kilpatrick, T. J., & Butzkueven, H. (2010) · Multiple Sclerosis Journal · doi:10.1177/1352458510389101 · Cited by 51

Dissecting the locus heterogeneity of autism: significant linkage to chromosome 12q14

Q, D., Cuccaro, M. L., Jaworski, J. M., Haynes, C. S., Stephan, D. A., Parod, J. M., Abramson, R. K., Wright, H. H., Gilbert, J. R., Haines, J. L., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001927 · Cited by 51

The genetics of multiple sclerosis

Lin, R., Charlesworth, J., van der Mei, I. A. F., & Taylor, B. V. (2012) · Practical Neurology · doi:10.1136/practneurol-2012-000276 · Cited by 51

Multiple Sclerosis Genetics

McElroy, J., & Oksenberg, J. R. (2007) · Current topics in microbiology and immunology · doi:10.1007/978-3-540-73677-6_3 · Cited by 49

Meta-analysis of genome-wide linkage studies across autoimmune diseases

Forabosco, P., Bouzigon, E., Ng, M., Hermanowski, J., Fisher, S. A., Criswell, L. A., & Lewis, C. M. (2008) · European Journal of Human Genetics · doi:10.1038/ejhg.2008.163 · Cited by 47

Genetic determinants of risk and progression in multiple sclerosis

Didonna, A., & Oksenberg, J. R. (2015) · Clinica Chimica Acta · doi:10.1016/j.cca.2015.01.034 · Cited by 49

Gender-based blood transcriptomes and interactomes in multiple sclerosis: Involvement of SP1 dependent gene transcription

Menon, R., Dario, M. D., Cordiglieri, C., Musio, S., Mantia, L. L., Milanese, C., Stefano, A. L. D., Crabbio, M., Franciotta, D. M., Bergamaschi, R., et al. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.11.004 · Cited by 46

Parental transmission of MS in a population-based Canadian cohort

Herrera, B. M., Ramagopalan, S. V., Orton, S. M., Chao, M., Yee, I. M. L., Sadovnick, A. D., & Ebers, G. C. (2007) · Neurology · doi:10.1212/01.wnl.0000268486.40851.d6 · Cited by 46

No evidence of association between mutant alleles of the CYP27B1 gene and multiple sclerosis

Ban, M., Caillier, S. J., Mero, I., Myhr, K., Celius, E. G., Aarseth, J. H., Torkildsen, Ø., Harbo, H. F., Oksenberg, J. R., Hauser, S. L., et al. (2012) · Annals of Neurology · doi:10.1002/ana.23833 · Cited by 45

Accuracy of Multiplexed Illumina Platform-Based Single-Nucleotide Polymorphism Genotyping Compared between Genomic and Whole Genome Amplified DNA Collected from Multiple Sources

Paynter, R. A., Skibola, D. R., Skibola, C. F., Buffler, P. A., Wiemels, J. L., & Smith, M. T. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0219 · Cited by 45

Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15

Traherne, J. A., Barcellos, L. F., Sawcer, S. J., Compston, A., Ramsay, P. P., Hauser, S. L., Oksenberg, J. R., & Trowsdale, J. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi436 · Cited by 45

Multiple sclerosis associates with LILRA3 deletion in Spanish patients

Ordóñez, D., Sánchez, A., Rodríguez, J., Cisneros, E., Ramil, E., Romo, N., Moraru, M., Munteis, E., López‐Botet, M., Roquer, J., et al. (2009) · Genes and Immunity · doi:10.1038/gene.2009.34 · Cited by 45

Interferon Gamma Allelic Variants

Kantarci, O. H., Hebrink, D. D., Schaefer-Klein, J. L., Sun, Y., Achenbach, S. J., Atkinson, E. J., Heggarty, S., Cotleur, A. C., de Andrade, M., Vandenbroeck, K., et al. (2008) · Archives of Neurology · doi:10.1001/archneurol.2007.66 · Cited by 43

Transmission of class I/II multi-locus MHC haplotypes and multiple sclerosis susceptibility: accounting for linkage disequilibrium

Chao, M., Barnardo, M., Lui, G., Lincoln, M. R., Ramagopalan, S. V., Herrera, B. M., Dyment, D. A., Sadovnick, A. D., & Ebers, G. C. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm142 · Cited by 42

Low frequency of the disease‐associated DRB1*15‐DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami

Harbo, H. F., Utsi, E., Lorentzen, Å. R., Kampman, M. T., Celius, E. G., Myhr, K. M., Lie, B. A., Mellgren, S. I., & Thorsby, E. (2007) · Tissue Antigens · doi:10.1111/j.1399-0039.2007.00803.x · Cited by 40

Environmental factors in early childhood are associated with multiple sclerosis: a case-control study

Conradi, S., Malzahn, U., Schröter, F., Paul, F., Quill, S., Spruth, E. J., Harms, L., Bergh, F. T., Ditzenbach, A., Georgi, T., et al. (2011) · BMC Neurology · doi:10.1186/1471-2377-11-123 · Cited by 39

Association between the ACCN1 Gene and Multiple Sclerosis in Central East Sardinia

Bernardinelli, L., Murgia, S. B., Bitti, P. P., Foco, L., Ferrai, R., Musu, L., Prokopenko, I., Pastorino, R., Saddi, V., Ticca, A., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000480 · Cited by 43

Mapping gene activity in complex disorders: Integration of expression and genomic scans for multiple sclerosis.

Fernald, G., Yeh, R., Hauser, S., Oksenberg, J., & Baranzini, S. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.06.032 · Cited by 43

The role of inflammatory bowel disease susceptibility loci in multiple sclerosis and systemic lupus erythematosus

Jager, P. L. D., Graham, R., Farwell, L. M., Sawcer, S. J., Richardson, A. M., Behrens, T. W., Compston, A., Hafler, D. A., Kere, J., Vyse, T. J., et al. (2006) · Genes and Immunity · doi:10.1038/sj.gene.6364303 · Cited by 40

Evaluating the role of the 620W allele of protein tyrosine phosphatase PTPN22 in Crohn's disease and multiple sclerosis

Jager, P. L. D., Sawcer, S. J., Waliszewska, A., Farwell, L. M., Wild, G., Cohen, A., Langelier, D., Bitton, A., Compston, A., Hafler, D. A., et al. (2005) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201548 · Cited by 38

Complex gene–gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes

Motsinger‐Reif, A. A., Brassat, D., Caillier, S. J., Erlich, H. A., Walker, K., Steiner, L. L., Barcellos, L. F., Pericak‐Vance, M. A., Schmidt, S., Gregory, S. G., et al. (2006) · Neurogenetics · doi:10.1007/s10048-006-0058-9 · Cited by 38

MYO9B gene polymorphisms are associated with autoimmune diseases in Spanish population

Sánchez, E., Alizadeh, B. Z., Valdigem, G., Ortego‐Centeno, N., Jiménez-Alonso, J. F., de Ramón, E., García, A., López‐Nevot, M. Á., Wijmenga, C., Martin, J. J., et al. (2007) · Human Immunology · doi:10.1016/j.humimm.2007.03.006 · Cited by 38

Bayes factors in complex genetics

Sawcer, S. J. (2010) · European Journal of Human Genetics · doi:10.1038/ejhg.2010.17 · Cited by 37

Pathways to cures for multiple sclerosis: A research roadmap

Bebo, B. F., Allegretta, M., Landsman, D., Zackowski, K. M., Brabazon, F., Kostich, W. A., Coetzee, T., Ng, A. V., Marrie, R. A., Monk, K. R., et al. (2022) · Multiple Sclerosis Journal · doi:10.1177/13524585221075990 · Cited by 43

The genetics of multiple sclerosis and its experimental models

Olsson, T. P., & Hillert, J. A. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3282fd10cc · Cited by 34

Multiple sclerosis: an update for oral health care providers

Fischer, D. J., Epstein, J. B., & Klasser, G. D. (2009) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2009.05.047 · Cited by 33

Risk conferring genes in multiple sclerosis

Nischwitz, S., Müller‐Myhsok, B., & Weber, F. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.037 · Cited by 35

Performance of Amplified DNA in an Illumina GoldenGate BeadArray Assay

Cunningham, J. M., Sellers, T. A., Schildkraut, J. M., Fredericksen, Z. S., Vierkant, R. A., Kelemen, L. E., Gadre, M. K., Phelan, C. M., Huang, Y., Meyer, J. G., et al. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-2849 · Cited by 34

Finding disease candidate genes by liquid association

Li, K.-C., Palotie, A. V., Yuan, S., Bronnikov, D., Chen, D., Wei, X., Choi, O., Saarela, J., & Peltonen, L. (2007) · Genome biology · doi:10.1186/gb-2007-8-10-r205 · Cited by 33

A whole genome screen for linkage disequilibrium in multiple sclerosis confirms disease associations with regions previously linked to susceptibility

Sawcer, S. J., Maranian, M. J., Setakis, E., Curwen, V., Akesson, E., Hensiek, A. E., Coraddu, F., Roxburgh, R. H., Sawcer, D., Gray, J., et al. (2002) · Brain · doi:10.1093/brain/awf143 · Cited by 111

A meta-analysis of genomic screens in multiple sclerosis

Cooperative, T. T. M. S. G. (2001) · Multiple Sclerosis Journal · doi:10.1177/135245850100700102 · Cited by 39

Updated results of the United Kingdom linkage-based genome screen in multiple sclerosis

Hensiek, A. E., Roxburgh, R. H., Smilie, B., Coraddu, F., Åkesson, E., Holmans, P., Sawcer, S. J., & Compston, D. A. S. (2003) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.08.007 · Cited by 42

A Second-Generation Genomic Screen for Multiple Sclerosis

Kenealy, S. J., Babron, M., Bradford, Y. M., Schnetz‐Boutaud, N. C., Haines, J. L., Rimmler, J. B., Schmidt, S., Pericak‐Vance, M. A., Barcellos, L. F., Lincoln, R., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/426459 · Cited by 57

A meta-analysis of whole genome linkage screens in multiple sclerosis

(2003) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2003.08.009 · Cited by 115