Assessment of the Utility of Viral Culture of Cerebrospinal Fluid
Abstract
Nucleic acid amplification testing is the preferred method to detect enteroviruses and Herpesviridae in cerebrospinal fluid, but clinicians still request viral culture. Review of 22,394 viral cultures of cerebrospinal fluid samples found that <0.1% recovered nonenterovirus, non-Herpesviridae species, suggesting that, when nucleic acid amplification testing is performed, viral culture may have no additional benefit.
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Molecular diagnostics have become the gold standard for demonstrating viral DNA or RNA in the CSF.
“Since its implementation, molecular diagnostics have become the gold standard for demonstrating viral DNA or RNA in the CSF (15).”
From Molecular diagnostics in cerebrospinal fluid for the diagnosis of central nervous system infections (2024) · cites this paper as [15]
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Laboratory diagnosis of central nervous system infection
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Self-citationMolecular diagnostics in cerebrospinal fluid for the diagnosis of central nervous system infections
Olie, S. E., Andersen, C. Ø., van de Beek, D., & Brouwer, M. C. (2024) · Clinical Microbiology Reviews · doi:10.1128/cmr.00021-24 · Cited by 38 · see citing works
“Since its implementation, molecular diagnostics have become the gold standard for demonstrating viral DNA or RNA in the CSF (15).”
- Authors
- Polage, C. R., & Petti, C. A.
- Affiliations
- University of Utah (US)
- Corresponding author
- Polage, C. R.
- ORCID
- Polage, C. R.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-12-15
- Volume
- 43
- Issue
- 12
- Pages
- 1578-1579
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2100322429
- Cited by
- 61
- References
- 10
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 2 · 2016: 8 · 2015: 5 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 2.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Keywords
- enterovirus, herpesvirus, nucleic acid amplification tests, virus detection, diagnostic yield, viral meningitis
- MeSH terms
- Cost-Benefit Analysis, Enterovirus Infections, Enterovirus, Herpesviridae, Herpesviridae Infections, Humans, Virus Cultivation, Nucleic Acid Amplification Techniques
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