Laboratory diagnosis of central nervous system infection

He, Taojun; Kaplan, Samuel; Kamboj, Mini; Tang, Yi-Wei

doi:10.1007/s11908-016-0545-6

Cited by 81Bacterial Identification and Susceptibility TestingBacterial Infections and VaccinesInfectious Encephalopathies and Encephalitis

Laboratory diagnosis of central nervous system infection

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He, Taojun, Kaplan, Samuel, Kamboj, Mini, Tang, Yi-Wei·2016·Current Infectious Disease Reports

DOI 10.1007/s11908-016-0545-6PMC PMC5612431

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Abstract

Central nervous system (CNS) infections are potentially life threatening if not diagnosed and treated early. The initial clinical presentations of many CNS infections are non-specific, making a definitive etiologic diagnosis challenging. Nucleic acid in vitro amplification-based molecular methods are increasingly being applied for routine microbial detection. These methods are a vast improvement over conventional techniques with the advantage of rapid turnaround and higher sensitivity and specificity. Additionally, molecular methods performed on cerebrospinal fluid samples are considered the new gold standard for diagnosis of CNS infection caused by pathogens, which are otherwise difficult to detect. Commercial diagnostic platforms offer various monoplex and multiplex PCR assays for convenient testing of targets that cause similar clinical illness. Pan-omic molecular platforms possess potential for use in this area. Although molecular methods are predicted to be widely used in diagnosing and monitoring CNS infections, results generated by these methods need to be carefully interpreted in combination with clinical findings. This review summarizes the currently available armamentarium of molecular assays for diagnosis of central nervous system infections, their application, and future approaches.

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Self-citation
Molecular diagnostics in cerebrospinal fluid for the diagnosis of central nervous system infections
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Laboratory diagnosis of CNS infections by molecular amplification techniques
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Self-citation
An Overview of Laboratory Diagnosis of Central Nervous System Viral Infections
Hussin, S. A. D. S., Chua, A.-L., Al-Talib, H. I., Sekaran, S. D., & Wang, S. M. (2022) · Journal of Pure and Applied Microbiology · doi:10.22207/jpam.16.4.34 · Cited by 4 · see citing works

Authors: He, T., Kaplan, S., Kamboj, M., & Tang, Y.-W.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
Corresponding author: Tang, Yi-Wei
ORCID: Kamboj, Mini
Tang, Yi-Wei
Venue: Current Infectious Disease Reports
Publisher: Springer Science and Business Media LLC
Published: 2016-09-30
Volume: 18
Issue: 11
Pages: 35-35
ISSN: 1523-3847 (ISSN-L)
1534-3146
DOI: 10.1007/s11908-016-0545-6
PMC: PMC5612431
OpenAlex: W2526342569
Cited by: 81
References: 97
Citations by year: 2026: 8 · 2025: 9 · 2024: 10 · 2023: 9 · 2022: 9 · 2021: 8 · 2020: 10 · 2019: 8 · 2018: 6 · 2017: 3 · 2016: 1
FWCI: 0.64
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (unspecified)
Locations: Current Infectious Disease Reports (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P30CA008748)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
Keywords: central nervous system infection, cerebrospinal fluid, molecular diagnosis, nucleic acid amplification, PCR testing, multiplex PCR, etiological diagnosis, meningitis, encephalitis

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