In Vivo Comparison of the Pharmacodynamic Targets for Echinocandin Drugs against Candida Species

Andes, D.; Diekema, D. J.; Pfaller, M. A.; Bohrmuller, J.; Marchillo, K.; Lepak, A.

doi:10.1128/aac.01584-09

Cited by 226Antifungal resistance and susceptibilityAntibiotics Pharmacokinetics and EfficacyFungal Infections and Studies

In Vivo Comparison of the Pharmacodynamic Targets for Echinocandin Drugs against Candida Species

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Andes, D., Diekema, D. J., Pfaller, M. A., Bohrmuller, J., Marchillo, K., Lepak, A.·2010·Antimicrobial Agents and Chemotherapy

DOI 10.1128/aac.01584-09PMC PMC2876357

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Abstract

Previous pharmacodynamic studies using in vivo candidiasis models have demonstrated that the 24-h area under the concentration-time curve (AUC)/MIC is a good descriptor of the echinocandin exposure-response relationship. Further studies investigating the 24-h AUC/MIC target for a stasis endpoint identified free-drug 24-h AUC/MIC against Candida albicans and were similar for two echinocandins, anidulafungin and micafungin. The current studies expand investigation of a third echinocandin (caspofungin) and compare the pharmacodynamic target among C. albicans , Candida glabrata , and Candida parapsilosis . Treatment studies were conducted with six C. albicans , nine C. glabrata , and 15 C. parapsilosis strains with various MICs (anidulafungin, 0.015 to 4.0 μg/ml; caspofungin, 0.03 to 4.0 μg/ml; and micafungin, 0.008 to 1.0 μg/ml). Efficacy was closely tied to MIC and the 24-h AUC/MIC. Therapy against C. parapsilosis required more of each echinocandin on a mg/kg basis. Caspofungin required less drug on a mg/kg basis for efficacy against all of the organisms than did the other two drugs. However, the 24-h AUC/MIC targets were similar among the echinocandins when free drug concentrations were considered, suggesting the relevance of protein binding. The targets for C. parapsilosis (mean, 7) and C. glabrata (mean, 7) were significantly lower than those for C. albicans (mean, 20) for each echinocandin. The results suggest that current susceptibility breakpoints and the consideration of organism species in these determinations should be reexplored.

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The amount of echinocandin relative to the MIC needed for efficacy was higher for C. albicans than for C. glabrata or C. parapsilosis.
“The results of these studies demonstrated the amount of echinocandin relative to the MIC needed for efficacy was higher for C albicans than for C glabrata or C parapsilosis.”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [165]
The free drug AUC/MIC target for echinocandins was approximately 5 to 7 for C. parapsilosis and C. glabrata, whereas for C. albicans the target AUC/MIC was approximately 10 to 20.
“The free drug AUC/MIC target was much less for C parapsilosis and C glabrata at approximately 5 to 7, whereas for C albicans the target AUC/MIC was approximately 10 to 20.”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [165]

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Pappas, P. G., Kauffman, C. A., Andes, D., Benjamin, D. K., Calandra, T. F., Edwards, J. E., Filler, S. G., Fisher, J. F., Kullberg, B.-J., Zeichner, L. O., et al. (2009) · Clinical Infectious Diseases · doi:10.1086/596757 · Cited by 3,191 · see citing works
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Craig, W. A. (1998) · Clinical Infectious Diseases · doi:10.1086/516284 · Cited by 2,908 · see citing works
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Mora-Duarte, J., Betts, R., Rotstein, C., Colombo, A. L., Thompson-Moya, L., Smietana, J., Lupinacci, R., Sable, C., Kartsonis, N., & Perfect, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021585 · Cited by 1,380 · see citing works
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Reboli, A. C., Rotstein, C., Pappas, P. G., Chapman, S. W., Kett, D. H., Kumar, D., Betts, R., Wible, M., Goldstein, B. P., Schranz, J., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa066906 · Cited by 894 · see citing works
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Rex, J. H., Pfaller, M. A., Galgiani, J. N., Bartlett, M. S., Espinel-Ingroff, A., Ghannoum, M. A., Lancaster, M., Odds, F. C., Rinaldi, M. G., Walsh, T. J., et al. (1997) · Clinical Infectious Diseases · doi:10.1093/clinids/24.2.235 · Cited by 855 · see citing works
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Kuse, E.-R., Chetchotisakd, P., da Cunha, C. A., Ruhnke, M., Barrios, C., Raghunadharao, D., Sekhon, J. S., Freire, A., Ramasubramanian, V., Demeyer, I., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60605-9 · Cited by 692 · see citing works
Clinical Practice Guidelines for the Management of Candidiasis: 2009 Update by the Infectious Diseases Society of America
Parczewska, O. K., Posaconazol, przeciwgrzybicze, L., Anidulafungina, Micafungina, & wrażliwość, O. (2009) · Cited by 656 · see citing works
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Hébert, M. F., Smith, H. E., Marbury, T. C., Swan, S. K., Smith, W. B., Townsend, R. W., Buell, D. N., Keirns, J. J., & Bekersky, I. (2005) · The Journal of Clinical Pharmacology · doi:10.1177/0091270005279580 · Cited by 181 · see citing works
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Self-citation
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Arendrup, M. C., Horn, T. D., & Møller, J. K. (2002) · Infection · doi:10.1007/s15010-002-2131-0 · Cited by 167 · see citing works
Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743,872)
Hajdu, R., Thompson, R. K., Sundelof, J. G., PELAK, B. A., Bouffard, F. A., Dropinski, J. F., & Kropp, H. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.11.2339 · Cited by 165 · see citing works
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Louie, A., Deziel, M. R., Liu, W., Drusano, M. F., Gumbo, T., & Drusano, G. L. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.12.5058-5068.2005 · Cited by 163 · see citing works
Caspofungin Resistance inCandida albicans: Correlating Clinical Outcome with Laboratory Susceptibility Testing of Three Isogenic Isolates Serially Obtained from a Patient with Progressive Candida Esophagitis
Hernandez, S., López-Ribot, J. L., Najvar, L. K., McCarthy, D. I., Bocanegra, R., & Graybill, J. R. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.4.1382-1383.2004 · Cited by 162 · see citing works
In Vitro Activities of Anidulafungin against More than 2,500 Clinical Isolates of Candida spp., Including 315 Isolates Resistant to Fluconazole
Pfaller, M. A., Boyken, L., Hollis, R. J., Messer, S. A., Tendolkar, S., & Diekema, D. J. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.11.5425-5427.2005 · Cited by 161 · see citing works
Self-citation
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Hakki, M., Staab, J. F., & Marr, K. A. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00148-06 · Cited by 148 · see citing works
Increasing incidence of Candida parapsilosis candidemia with caspofungin usage.
Forrest, G. N., Weekes, E., & Johnson, J. K. (2008) · Journal of Infection · doi:10.1016/j.jinf.2007.10.014 · Cited by 144 · see citing works
In vivo pharmacodynamic characterization of anidulafungin in a neutropenic murine candidiasis model
Andes, D., Diekema, D. J., Pfaller, M. A., Prince, R. A., Marchillo, K., Ashbeck, J., & Hou, J. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01061-07 · Cited by 140 · see citing works
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Kartsonis, N. A., Killar, J., Mixson, L. A., Hoe, C., Sable, C. A., Bartizal, K. F., & Motyl, M. R. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.9.3616-3623.2005 · Cited by 137 · see citing works
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Geographic and Temporal Trends in Isolation and Antifungal Susceptibility of Candida parapsilosis : a Global Assessment from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005
Pfaller, M. A., Diekema, D. J., Gibbs, D. L., Newell, V. A., Ng, K. P., Colombo, A. L., Finquelievich, J. L., Barnes, R. A., & Wadula, J. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.02122-07 · Cited by 105 · see citing works
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Asbeck, E. C. V., Clemons, K. V., Markham, A. N., et al. (2009) · Mycoses · doi:10.1111/j.1439-0507.2008.01649.x · Cited by 28 · see citing works
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Andes, D. R. (2005) · Humana Press eBooks · doi:10.1385/1-59259-943-5:111 · Cited by 28 · see citing works
Self-citation
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Authors: Andes, D., Diekema, D. J., Pfaller, M. A., Bohrmuller, J., Marchillo, K., & Lepak, A.
Affiliations: University of Wisconsin–Madison (US)
University of Iowa (US)
ORCID: Andes, D.
Diekema, D. J.
Pfaller, M. A.
Lepak, A.
Venue: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Published: 2010-06
Volume: 54
Issue: 6
Pages: 2497-2506
ISSN: 0066-4804 (ISSN-L)
1098-6596
DOI: 10.1128/aac.01584-09
PMC: PMC2876357
OpenAlex: W2147335917
Cited by: 226
References: 57
Citations by year: 2026: 5 · 2025: 8 · 2024: 11 · 2023: 11 · 2022: 9 · 2021: 16 · 2020: 21 · 2019: 10 · 2018: 11 · 2017: 18 · 2016: 15 · 2015: 10 · 2014: 18 · 2013: 15 · 2012: 14
FWCI: 12.81
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Antimicrobial Agents and Chemotherapy (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Pfizer
Astellas Pharma
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords: echinocandins, caspofungin, anidulafungin, micafungin, Candida albicans, Candida glabrata, Candida parapsilosis, therapeutic target, AUC/MIC, free drug concentration, protein binding, antifungal susceptibility breakpoints
MeSH terms: Caspofungin, Micafungin, Anidulafungin, Animals, Antifungal Agents, Candida, Candida albicans, Candidiasis, Female, Kidney, Mice, Inbred ICR, Microbial Sensitivity Tests, Protein Binding, Species Specificity, Candida glabrata, Mice, Echinocandins, Lipopeptides

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In Vivo Comparison of the Pharmacodynamic Targets for Echinocandin Drugs against Candida Species

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