The DOI matches its Crossref record; 126 of the 126 references it cites were found in a registry or an index.
Resistance to Therapies for Infection by Plasmodium vivax
Open accessAbstract
SUMMARY: The gravity of the threat posed by vivax malaria to public health has been poorly appreciated. The widely held misperception of Plasmodium vivax as being relatively infrequent, benign, and easily treated explains its nearly complete neglect across the range of biological and clinical research. Recent evidence suggests a far higher and more-severe disease burden imposed by increasingly drug-resistant parasites. The two frontline therapies against vivax malaria, chloroquine and primaquine, may be failing. Despite 60 years of nearly continuous use of these drugs, their respective mechanisms of activity, resistance, and toxicity remain unknown. Although standardized means of assessing therapeutic efficacy against blood and liver stages have not been developed, this review examines the provisional in vivo, ex vivo, and animal model systems for doing so. The rationale, design, and interpretation of clinical trials of therapies for vivax malaria are discussed in the context of the nuance and ambiguity imposed by the hypnozoite. Fielding new drug therapies against real-world vivax malaria may require a reworking of the strategic framework of drug development, namely, the conception, testing, and evaluation of sets of drugs designed for the cure of both blood and liver asexual stages as well as the sexual blood stages within a single therapeutic regimen.
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Cites
The global distribution and population at risk of malaria: past, present, and future
Hay, S. I., Guerra, C. A., Tatem, A. J., Noor, A. M., & Snow, R. W. (2004) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(04)01043-6 · Cited by 1,001
(1973) · Annals of Internal Medicine · doi:10.7326/0003-4819-79-2-324_1 · Cited by 994
The neglected burden of Plasmodium vivax malaria
Mendis, K., Sina, B., Marchesini, P., & Carter, R. (2001) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2001.64.97 · Cited by 970
Vivax Malaria: Neglected and Not Benign
Price, R. N., Tjitra, E., Guerra, C. A., Yeung, S., White, N. J., & Anstey, N. M. (2007) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2007.77.79 · Cited by 838
Space-Time Relationships in Somesthetic Localization
Jones, F. N. (1956) · Science · doi:10.1126/science.124.3220.484-a · Cited by 836
Beutler, E. (1994) · Blood · doi:10.1182/blood.v84.11.3613.bloodjournal84113613 · Cited by 731
Tjitra, E., Anstey, N. M., Sugiarto, P., Warikar, N., Kenangalem, E., Karyana, M., Lampah, D. A., & Price, R. N. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050128 · Cited by 611
Ruwende, C., Khoo, S. C., Snow, R. W., Yates, S. N. R., Kwiatkowski, D., Gupta, S., Warn, P., Allsopp, C. E. M., Gilbert, S. C., Peschu, N., et al. (1995) · Nature · doi:10.1038/376246a0 · Cited by 595
Genton, B., D'Acremont, V., Rare, L., Baea, K., Reeder, J. C., Alpers, M. P., & Müller, I. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050127 · Cited by 463
Coatney, G. R., Collins, W. E., Warren, M., & Contacos, P. G. (1971) · Cited by 454
Cited by
Bousema, T., & Drakeley, C. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00051-10 · Cited by 746
A Long Neglected World Malaria Map: Plasmodium vivax Endemicity in 2010
Gething, P. W., Elyazar, I. R. F., Moyes, C. L., Smith, D. L., Battle, K. E., Guerra, C. A., Patil, A. P., Tatem, A. J., Howes, R. E., Myers, M. F., et al. (2012) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0001814 · Cited by 538
Self-citationOperational strategies to achieve and maintain malaria elimination
Moonen, B., Cohen, J. M., Snow, R. W., Slutsker, L., Drakeley, C., Smith, D. L., Abeyasinghe, R. R., Rodriguez, M. H., Maharaj, R., Tanner, M., et al. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61269-x · Cited by 381
Malaria in pregnancy in the Asia-Pacific region
Rijken, M. J., McGready, R., Boel, M. E., Poespoprodjo, R., Singh, N., Syafruddin, D., Rogerson, S., & Nosten, F. (2012) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(11)70315-2 · Cited by 181
Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand
Rijken, M. J., Boel, M. E., Russell, B., Imwong, M., Leimanis, M. L., Phyo, A. P., Muehlenbachs, A., Lindegardh, N., McGready, R., Rénia, L., et al. (2011) · Malaria Journal · doi:10.1186/1475-2875-10-113 · Cited by 62
“Chloroquine (CQ) remains the recommended first-line treatment for Plasmodium vivax globally except for Indonesia, Papua New Guinea, the Solomon Islands and Vanuatu where widespread CQ resistance prompted a change in treatment policy [1,2].”
Background
Metadata
- Authors
- Baird, J. K.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2009-07
- Volume
- 22
- Issue
- 3
- Pages
- 508-534
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2132107151
- Cited by
- 262
- References
- 126
- FWCI
- 30.57
- Type
- journal article
- Language
- en
- Open access
- green
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