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Survival and Prognostic Factors of Invasive Aspergillosis After Allogeneic Bone Marrow Transplantation
Open accessAbstract
To determine prognostic factors for survival in bone marrow transplant recipients with invasive aspergillosis (IA), we retrospectively reviewed 27 IA cases observed in our bone marrow transplantation unit between January 1994 and October 1994. On 30 September 1997, six patients were alive and disease-free. The median survival after IA diagnosis was 36 days. Of eight variables found to be related to survival according to the univariate analysis, graft-versus-host disease (GVHD) status at IA diagnosis (P = .0008) and the cumulative prednisolone dose taken during the week preceding IA diagnosis (CPDlw) (P < .0001) were selected by a backward stepwise Cox regression model. A three-stage classification was established: CPD1w of < or =7 mg/kg (3 of 8 patients died; 60-day survival rate, 88%), CPD1w of >7 mg/kg and no GVHD (9 of 10 patients died; 60-day survival rate, 20%), and CPD1w of >7 mg/kg and active acute grade 2 or more or extensive chronic GVHD (9 of 9 patients died; 30-day survival rate, 0) (P < .0001).
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Citations
Cited by
Aspergillus fumigatus and Aspergillosis
Latgé, J.-P. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.2.310 · Cited by 2,307
Denning, D. W. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14472-8 · Cited by 1,131
Walsh, T. J., Pappas, P., Winston, D. J., Lazarus, H. M., Petersen, F., Raffalli, J., Yanovich, S., Stiff, P., Greenberg, R., Donowitz, G., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejm200201243460403 · Cited by 979
Marr, K. A., Carter, R. A., Boeckh, M., Martin, P., & Corey, L. (2002) · Blood · doi:10.1182/blood-2002-05-1496 · Cited by 957
Efficacy and safety of voriconazole in the treatment of acute invasive aspergillosis
Denning, D. W., Ribaud, P., Milpied, N., Caillot, D., Herbrecht, R., Thiel, E., Haas, A., Ruhnke, M., & Lode, H. (2002) · Clinical Infectious Diseases · doi:10.1086/324620 · Cited by 844
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Metadata
- Authors
- Ribaud, P., Chastang, C., Latgé, J., Baffroy‐Lafitte, L., Parquet, N., Espéton, A. D. H., Sélimi, F., Rocha, V., Derouin, F., Socié, G., & Glucknan, E.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-02
- Volume
- 28
- Issue
- 2
- Pages
- 322-330
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2133248401
- Cited by
- 236
- References
- 0
- FWCI
- 14.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Survival and Prognostic Factors of Invasive Aspergillosis After Allogeneic Bone Marrow Transplantation. https://app.cochat.ai/papers/10.1086/515116
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- Ribaud, P., Chastang, C., Latgé, J., Baffroy‐Lafitte, L., Parquet, N., Espéton, A. D. H., Sélimi, F., Rocha, V., Derouin, F., Socié, G., & Glucknan, E. (1999). Survival and Prognostic Factors of Invasive Aspergillosis After Allogeneic Bone Marrow Transplantation. Clinical Infectious Diseases. https://doi.org/10.1086/515116
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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