Cited by 4,917Antifungal resistance and susceptibilityFungal Infections and StudiesNeutropenia and Cancer Infections

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group

Open access

De Pauw, Ben, Walsh, Thomas J., Donnelly, J. Peter, Stevens, David A., Edwards, John E., Calandra, Thierry, Pappas, Peter G., Maertens, Johan, Lortholary, Olivier, Kauffman, Carol A., Denning, David W., Patterson, Thomas F., Maschmeyer, Georg, Bille, Jacques, Dismukes, William E., Herbrecht, Raoul, Hope, William W., Kibbler, Christopher C., Kullberg, Bart Jan, Marr, Kieren A., Muñoz, Patricia, Odds, Frank C., Perfect, John R., Restrepo, Angela, Ruhnke, Markus, Segal, Brahm H., Sobel, Jack D., Sorrell, Tania C., Viscoli, Claudio, Wingard, John R., Zaoutis, Theoklis, Bennett, John E.·2008·Clinical Infectious Diseases

DOI 10.1086/588660PMC PMC2671227

Open this paper in CoChat — free account Open PDF

Abstract

BACKGROUND: Invasive fungal diseases are important causes of morbidity and mortality. Clarity and uniformity in defining these infections are important factors in improving the quality of clinical studies. A standard set of definitions strengthens the consistency and reproducibility of such studies. METHODS: After the introduction of the original European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group definitions, advances in diagnostic technology and the recognition of areas in need of improvement led to a revision of this document. The revision process started with a meeting of participants in 2003, to decide on the process and to draft the proposal. This was followed by several rounds of consultation until a final draft was approved in 2005. This was made available for 6 months to allow public comment, and then the manuscript was prepared and approved. RESULTS: The revised definitions retain the original classifications of "proven," "probable," and "possible" invasive fungal disease, but the definition of "probable" has been expanded, whereas the scope of the category "possible" has been diminished. The category of proven invasive fungal disease can apply to any patient, regardless of whether the patient is immunocompromised, whereas the probable and possible categories are proposed for immunocompromised patients only. CONCLUSIONS: These revised definitions of invasive fungal disease are intended to advance clinical and epidemiological research and may serve as a useful model for defining other infections in high-risk patients.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1086/588660

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Voriconazole versus Amphotericin B for Primary Therapy of Invasive Aspergillosis
Herbrecht, R., Denning, D. W., Patterson, T. F., Bennett, J. E., Greene, R. E., Oestmann, J.-W., Kern, W. V., Marr, K. A., Ribaud, P., Lortholary, O., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020191 · Cited by 3,304
Self-citation
Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America
Walsh, T. J., Anaissie, E. J., Denning, D. W., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Segal, B. H., Steinbach, W. J., Stevens, D. A., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/525258 · Cited by 2,705
Self-citation
Defining Opportunistic Invasive Fungal Infections in Immunocompromised Patients with Cancer and Hematopoietic Stem Cell Transplants: An International Consensus
Aşçıoğlu, S., Rex, J. H., de Pauw, B., Bennett, J. E., Billé, J., Crokaert, F., Denning, D. W., Donnelly, J. P., Edwards, J. E., Erjavec, Z., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/323335 · Cited by 2,315
Self-citation
Posaconazole vs. Fluconazole or Itraconazole Prophylaxis in Patients with Neutropenia
Cornely, O. A., Maertens, J. A., Winston, D. J., Perfect, J. R., Ullmann, A. J., Walsh, T. J., HELFGOTT, D. C., Hołowiecki, J., Stockelberg, D., Goh, Y. T., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa061094 · Cited by 1,802
Self-citation
Posaconazole or Fluconazole for Prophylaxis in Severe Graft-versus-Host Disease
Ullmann, A. J., Lipton, J. H., Vesole, D. H., Chandrasekar, P. H., Langston, A. A., Tarantolo, S., Greinix, H., de Azevedo, W. M., Reddy, V. S., Boparai, N., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa061098 · Cited by 1,339
Voriconazole Compared with Liposomal Amphotericin B for Empirical Antifungal Therapy in Patients with Neutropenia and Persistent Fever
Walsh, T. J., Pappas, P., Winston, D. J., Lazarus, H. M., Petersen, F., Raffalli, J., Yanovich, S., Stiff, P., Greenberg, R., Donowitz, G., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejm200201243460403 · Cited by 979
Self-citation
Caspofungin versus Liposomal Amphotericin B for Empirical Antifungal Therapy in Patients with Persistent Fever and Neutropenia
Walsh, T. J., Teppler, H., Donowitz, G. R., Maertens, J. A., Baden, L. R., Dmoszyńska, A., Cornely, O. A., Bourque, M. R., Lupinacci, R. J., Sable, C. A., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040446 · Cited by 907
Self-citation
Glossary of terms for CT of the lungs: recommendations of the Nomenclature Committee of the Fleischner Society.
Austin, J. H. M., Müller, N. L., Friedman, P. J., Hansell, D. M., Naidich, D. P., Rémy-Jardin, M., Webb, W. R., & Zerhouni, E. A. (1996) · Radiology · doi:10.1148/radiology.200.2.8685321 · Cited by 836
Invasive Aspergillosis Disease Spectrum, Treatment Practices, and Outcomes
Patterson, T. F., Kirkpatrick, W. R., White, M., Hiemenz, J. W., WINGARD, J. R., DUPONT, B., RINALDI, M. G., STEVENS, D. A., & Graybill, J. R. (2000) · Medicine · doi:10.1097/00005792-200007000-00006 · Cited by 791
Self-citation
Liposomal Amphotericin B as Initial Therapy for Invasive Mold Infection: A Randomized Trial Comparing a High-Loading Dose Regimen with Standard Dosing (AmBiLoad Trial)
Cornely, O. A., Maertens, J. A., Bresnik, M., Ebrahimi, R., Ullmann, A. J., Bouza, E., Heußel, C. P., Lortholary, O., Rieger, C. T., Boehme, A., et al. (2007) · Clinical Infectious Diseases · doi:10.1086/514341 · Cited by 744
Self-citation
Multicenter Clinical Evaluation of the (1->3) -D-Glucan Assay as an Aid to Diagnosis of Fungal Infections in Humans
Ostrosky-Zeichner, L., Alexander, B. D., Kett, D. H., Vazquez, J., Pappas, P. G., Saeki, F., Ketchum, P. A., Wingard, J., Schiff, R., Tamura, H., et al. (2005) · Clinical Infectious Diseases · doi:10.1086/432470 · Cited by 669
Self-citation
-D-Glucan as a Diagnostic Adjunct for Invasive Fungal Infections: Validation, Cutoff Development, and Performance in Patients with Acute Myelogenous Leukemia and Myelodysplastic Syndrome
Odabaşı, Z., Mattiuzzi, G. N., Estey, E., Kantarjian, H. M., Saeki, F., Ridge, R. J., Ketchum, P. A., Finkelman, M., Rex, J. H., & Ostrosky‐Zeichner, L. (2004) · Clinical Infectious Diseases · doi:10.1086/421944 · Cited by 641
Imaging Findings in Acute Invasive Pulmonary Aspergillosis: Clinical Significance of the Halo Sign
Greene, R. E., Schlamm, H. T., Oestmann, J. W., Stark, P., Durand, C. M., Lortholary, O., Wingard, J. R., Herbrecht, R., Ribaud, P., Patterson, T. F., et al. (2007) · Clinical Infectious Diseases · doi:10.1086/509917 · Cited by 589
Self-citation
Plasma (1→3)-β-D-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes
Obayashi, T., Kawai, T., Yoshida, M., Mori, T., Goto, H., Yasuoka, A., Shimada, K., Iwasaki, H., Teshima, H., KOHNO, S., et al. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91152-9 · Cited by 530
Laboratory diagnosis of invasive aspergillosis
Hope, W., Walsh, T., & Denning, D. (2005) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(05)70238-3 · Cited by 495
Self-citation
Detection of Galactomannan Antigenemia by Enzyme Immunoassay for the Diagnosis of Invasive Aspergillosis: Variables That Affect Performance
Marr, K. A., Balajee, S. A., McLaughlin, L., Tabouret, M., Bentsen, C. G., & Walsh, T. J. (2004) · The Journal of Infectious Diseases · doi:10.1086/422009 · Cited by 481
Self-citation
Invasive aspergillosis in the intensive care unit
Meersseman, W., Lagrou, K., Maertens, J., & Wijngaerden, E. V. (2007) · Clinical Infectious Diseases · doi:10.1086/518852 · Cited by 366
Self-citation
Comparison of Epidemiological, Clinical, and Biological Features of Invasive Aspergillosis in Neutropenic and Nonneutropenic Patients: A 6‐Year Survey
Cornillet, A., Camus, C., Nimubona, S., Gandemer, V., Tattevin, P., Belleguic, C., Chevrier, S., Meunier, C., Lebert, C., Aupee, M., et al. (2006) · Clinical Infectious Diseases · doi:10.1086/505870 · Cited by 361
Contribution of (1→3)-β- d -Glucan Chromogenic Assay to Diagnosis and Therapeutic Monitoring of Invasive Aspergillosis in Neutropenic Adult Patients: a Comparison with Serial Screening for Circulating Galactomannan
Pazos, C., Pontón, J., & del Palacio, A. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.1.299-305.2005 · Cited by 335
Prospective Comparison of the Diagnostic Potential of Real-Time PCR, Double-Sandwich Enzyme-Linked Immunosorbent Assay for Galactomannan, and a (1→3)-β- d -Glucan Test in Weekly Screening for Invasive Aspergillosis in Patients with Hematological Disorders
Kawazu, M., Kanda, Y., Nannya, Y., Aoki, K., Kurokawa, M., Chiba, S., Motokura, T., Hirai, H., & Ogawa, S. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.6.2733-2741.2004 · Cited by 277
The invasive and saprophytic syndromes due toAspergillusspp.
Hope, W. W., Walsh, T. J., & Denning, D. W. (2005) · Medical Mycology · doi:10.1080/13693780400025179 · Cited by 225
Self-citation
Multicenter clinical evaluation of the (1→3)β-D-glucan assay as an aid to diagnosis of fungal infections in humans: Ostrosky-Zeichner L, Alexander BD, Kett DH, et al: Clin Infect Dis 41 (5) : 654-659, 2005
吉田, 耕., & 二木, 芳. (2006) · 深在性真菌症 · Cited by 219
Optimization of the Cutoff Value for the Aspergillus Double-Sandwich Enzyme Immunoassay
Maertens, J. A., Klont, R., Masson, C., Theunissen, K., Meersseman, W., Lagrou, K., Heinen, C., Crepin, B., Eldere, J. V., Tabouret, M., et al. (2007) · Clinical Infectious Diseases · doi:10.1086/514349 · Cited by 182
Self-citation
Diagnosis of Cryptococcal Meningitis
Goodman, J. S., Kaufman, L., & Koenig, M. G. (1971) · New England Journal of Medicine · doi:10.1056/nejm197108192850804 · Cited by 161
Serologic studies in coccidioidomycosis
Pappagianis, D. (2001) · Seminars in Respiratory Infections · doi:10.1053/srin.2001.29315 · Cited by 134
Polymerase Chain Reaction for Diagnosing Invasive Aspergillosis: Getting Closer but Still a Ways to Go
Donnelly, J. P. (2006) · Clinical Infectious Diseases · doi:10.1086/499818 · Cited by 114
Self-citation
Evaluation of Serum Sandwich Enzyme-Linked Immunosorbent Assay for Circulating Galactomannan during Caspofungin Therapy: Results from the Caspofungin Invasive Aspergillosis Study
Maertens, J. A., Glasmacher, A. G., Selleslag, D., Ngai, A., Ryan, D., Layton, M., Taylor, A., Sable, C. A., & Kartsonis, N. A. (2005) · Clinical Infectious Diseases · doi:10.1086/430826 · Cited by 43
Self-citation
Usefulness of the MSG/IFICG/EORTC diagnostic criteria of invasive pulmonary aspergillosis in the clinical management of patients with acute leukaemia developing pulmonary infiltrates
Borlenghi, E., Cattaneo, C. M., Capucci, M. A., Pan, A., Quaresmini, G., Franco, F., Grazioli, L., Carosi, G. P., & Rossi, G. (2006) · Annals of Hematology · doi:10.1007/s00277-006-0204-3 · Cited by 29

Flagged first, then by citations

Sorted by citations

Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium
Donnelly, J. P., Chen, S. C.-J., Kauffman, C. A., Steinbach, W. J., Baddley, J. W., Verweij, P. E., Clancy, C. J., Wingard, J. R., Lockhart, S. R., Groll, A. H., et al. (2019) · Clinical Infectious Diseases · doi:10.1093/cid/ciz1008 · Cited by 2,987
Self-citation
Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America
Patterson, T. F., Thompson, G. R., Denning, D. W., Fishman, J. A., Hadley, S., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Nguyen, M. H., et al. (2016) · Clinical Infectious Diseases · doi:10.1093/cid/ciw326 · Cited by 2,926
Self-citation
Guidelines for Preventing Infectious Complications among Hematopoietic Cell Transplantation Recipients: A Global Perspective
Tomblyn, M. R., Chiller, T. M., Einsele, H., Gress, R. E., Sepkowitz, K. A., Storek, J., Wingard, J. R., Young, J. H., & Boeckh, M. (2009) · Transplantation and Cellular Therapy · doi:10.1016/j.bbmt.2009.06.019 · Cited by 1,832
Self-citation
Invasive candidiasis
Pappas, P. G., Lionakis, M. S., Arendrup, M. C., Ostrosky-Zeichner, L., & Kullberg, B. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.26 · Cited by 1,636
Self-citation
Invasive Fungal Infections among Organ Transplant Recipients: Results of the Transplant‐Associated Infection Surveillance Network (TRANSNET)
Pappas, P. G., Alexander, B. D., Andes, D. R., Hadley, S., Kauffman, C. A., Freifeld, A., Anaissie, E. J., Brumble, L. M., Herwaldt, L., Ito, J., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/651262 · Cited by 1,570
Self-citation

See all 4,917

Authors: De Pauw, B., Walsh, T. J., Donnelly, J. P., Stevens, D. A., Edwards, J. E., Calandra, T., Pappas, P. G., Maertens, J., Lortholary, O., Kauffman, C. A., Denning, D. W., Patterson, T. F., Maschmeyer, G., Bille, J., Dismukes, W. E., Herbrecht, R., Hope, W. W., Kibbler, C. C., Kullberg, B. J., Marr, K. A., Muñoz, P., Odds, F. C., Perfect, J. R., Restrepo, A., Ruhnke, M., Segal, B. H., Sobel, J. D., Sorrell, T. C., Viscoli, C., Wingard, J. R., Zaoutis, T., & Bennett, J. E.
Affiliations: Radboud University Medical Center (NL)
Corresponding author: Donnelly, J. Peter
ORCID: Walsh, Thomas J.
Donnelly, J. Peter
Stevens, David A.
Edwards, John E.
Calandra, Thierry
Pappas, Peter G.
Maertens, Johan
Lortholary, Olivier
Denning, David W.
Patterson, Thomas F.
Maschmeyer, Georg
Herbrecht, Raoul
Hope, William W.
Kullberg, Bart Jan
Marr, Kieren A.
Perfect, John R.
Ruhnke, Markus
Segal, Brahm H.
Sobel, Jack D.
Sorrell, Tania C.
Wingard, John R.
Zaoutis, Theoklis
Bennett, John E.
Venue: Clinical Infectious Diseases
Publisher: Oxford University Press (OUP)
Published: 2008-06-15
Volume: 46
Issue: 12
Pages: 1813-1821
ISSN: 1058-4838 (ISSN-L)
1537-6591
DOI: 10.1086/588660
PMC: PMC2671227
OpenAlex: W2166734004
Cited by: 4,917
References: 28
Citations by year: 2026: 85 · 2025: 146 · 2024: 169 · 2023: 172 · 2022: 203 · 2021: 280 · 2020: 362 · 2019: 424 · 2018: 383 · 2017: 354 · 2016: 345 · 2015: 376 · 2014: 363 · 2013: 299 · 2012: 279
FWCI: 140.34
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Clinical Infectious Diseases (publishedVersion)
PubMed (publishedVersion)
Institutional Repository University of Antioquia (University of Antioquia) (publishedVersion, cc-by-nc-nd)
PubMed Central (acceptedVersion)
IRIS (submittedVersion)
UCL Discovery (University College London) (submittedVersion)
CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion, other-oa)
Radboud Repository (Radboud University) (submittedVersion, other-oa)
Funders: Amgen
Pfizer
GlaxoSmithKline
Sanofi
Gilead Sciences
Children's Hospital of Philadelphia
Wayne State University
University of Pennsylvania
Wellcome Trust
Valeant Pharmaceuticals International
European Commission
University of Aberdeen
European Organisation for Research and Treatment of Cancer
Astellas Pharma
Centre Hospitalier Universitaire Vaudois
Basilea Pharmaceutica
Italfarmaco
National Institutes of Health
University at Buffalo
Medical School, University of Michigan
University of Texas Health Science Center at San Antonio
Medical Research Council
National Health and Medical Research Council
National Institute of Allergy and Infectious Diseases (Z01AI000654)
Janssen Pharmaceuticals
UCB Pharma
Daiichi Sankyo Europe
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
Keywords: invasive fungal infections, diagnostic definitions, immunocompromised patients, clinical trial endpoints, fungal epidemiology
MeSH terms: Humans, Mycoses, Terminology as Topic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks