Perfect, John R.

Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group

De Pauw, B., Walsh, T. J., Donnelly, J. P., Stevens, D. A., Edwards, J. E., Calandra, T., Pappas, P. G., Maertens, J., Lortholary, O., Kauffman, C. A., et al. (2008) · Clinical Infectious Diseases

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 4,917

Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America

Perfect, J. R., Dismukes, W. E., Dromer, F., Goldman, D. L., Graybill, J. R., Hamill, R. J., Harrison, T. S., Larsen, R. A., Lortholary, O., Nguyen, M.-H., et al. (2010) · Clinical Infectious Diseases

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 2,660

Comparison of Caspofungin and Amphotericin B for Invasive Candidiasis

Mora-Duarte, J., Betts, R., Rotstein, C., Colombo, A. L., Thompson-Moya, L., Smietana, J., Lupinacci, R., Sable, C., Kartsonis, N., & Perfect, J. (2002) · New England Journal of Medicine

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 1,380

Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans

Mitchell, T. G., & Perfect, J. R. (1995) · Clinical Microbiology Reviews

Fungal Infections and StudiesBacterial Infections and Vaccines

Cited by 1,213

Voriconazole Compared with Liposomal Amphotericin B for Empirical Antifungal Therapy in Patients with Neutropenia and Persistent Fever

Walsh, T. J., Pappas, P., Winston, D. J., Lazarus, H. M., Petersen, F., Raffalli, J., Yanovich, S., Stiff, P., Greenberg, R., Donowitz, G., et al. (2002) · New England Journal of Medicine

Antifungal resistance and susceptibilityNeutropenia and Cancer Infections

Cited by 979

The antifungal pipeline: a reality check

Perfect, J. R. (2017) · Nature Reviews Drug Discovery

Antifungal resistance and susceptibilityFungal Plant Pathogen Control

Cited by 866

Human dectin-1 deficiency and mucocutaneous fungal infections

Ferwerda, B., Ferwerda, G., Plantinga, T. S., Willment, J. A., van Spriel, A. B., Venselaar, H., Elbers, C. C., Johnson, M. D., Cambi, A., Huysamen, C., et al. (2009) · New England Journal of Medicine

Immunodeficiency and Autoimmune DisordersAntifungal resistance and susceptibility

Cited by 752

Cryptococcosis

Maziarz, E. K., & Perfect, J. R. (2016) · Infectious Disease Clinics of North America

Fungal Infections and StudiesAntifungal resistance and susceptibility

Cited by 698

Resistance to Antifungal Agents: Mechanisms and Clinical Impact

Kanafani, Z. A., & Perfect, J. R. (2008) · Clinical Infectious Diseases

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 619

Combination antifungal therapy

Johnson, M. D., MacDougall, C., Ostrosky-Zeichner, L., Perfect, J. R., & Rex, J. H. (2004) · Antimicrobial Agents and Chemotherapy

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 541

Urease as a Virulence Factor in Experimental Cryptococcosis

Cox, G. M., Mukherjee, J., Cole, G. T., Casadevall, A., & Perfect, J. R. (2000) · Infection and Immunity

Fungal Infections and StudiesBacterial Infections and Vaccines

Cited by 522

Calcineurin is required for virulence of Cryptococcus neoformans

Odom, A., Muir, S., Lim, E., Toffaletti, D. L., Perfect, J., & Heitman, J. (1997) · The EMBO Journal

Fungal Infections and StudiesSignaling Pathways in Disease

Cited by 516

Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak

Fraser, J. A., Giles, S. S., Wenink, E. C., Geunes-Boyer, S. G., Wright, J. R., Diezmann, S., Allen, A., Stajich, J. E., Dietrich, F. S., Perfect, J. R., et al. (2005) · Nature

Fungal Infections and StudiesPlant Pathogens and Fungal Diseases

Cited by 499

The Impact of Culture Isolation of Aspergillus Species: A Hospital‐Based Survey of Aspergillosis

Perfect, J. R., Cox, G. M., Lee, J. Y., Kauffman, C. A., de Repentigny, L., Chapman, S. W., Morrison, V. A., Pappas, P., Hiemenz, J. W., Stevens, D. A., et al. (2001) · Clinical Infectious Diseases

Antifungal resistance and susceptibilityNeutropenia and Cancer Infections

Cited by 458

Voriconazole in the treatment of aspergillosis, scedosporiosis and other invasive fungal infections in children

WALSH, T. J., LUTSAR, I., DRISCOLL, T., DUPONT, B., RODEN, M., GHAHRAMANI, P., HODGES, M., GROLL, A. H., & PERFECT, J. R. (2002) · The Pediatric Infectious Disease Journal

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 431

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

Cowen, L. E., Singh, S. D., Köhler, J. R., Collins, C., Zaas, A. K., Schell, W. A., Aziz, H., Mylonakis, E., Perfect, J. R., Whitesell, L., et al. (2009) · Proceedings of the National Academy of Sciences

Antifungal resistance and susceptibilityHeat shock proteins research

Cited by 413

The Spectrum of Fungi That Infects Humans

Kohler, J. R., Casadevall, A., & Perfect, J. (2015) · Cold Spring Harbor Perspectives in Medicine

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 364

Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin

Singh, S. D., Robbins, N., Zaas, A. K., Schell, W. A., Perfect, J. R., & Cowen, L. E. (2009) · PLoS Pathogens

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 362

Calcineurin is essential for survival during membrane stress in Candida albicans

Cruz, M. C., Goldstein, A. L., Blankenship, J. R., Del Poeta, M., Davis, D., Cardenas, M. E., Perfect, J. R., McCusker, J. H., & Heitman, J. (2002) · The EMBO Journal

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 342

PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90

LaFayette, S. L., Collins, C., Zaas, A. K., Schell, W. A., Betancourt-Quiroz, M., Gunatilaka, A. A. L., Perfect, J. R., & Cowen, L. E. (2010) · PLoS Pathogens

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 329

Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections.

Steinbach, W. J., Reedy, J. L., Cramer, R. A., Perfect, J. R., & Heitman, J. (2007) · Nature Reviews Microbiology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 313

Hsp90 Orchestrates Temperature-Dependent Candida albicans Morphogenesis via Ras1-PKA Signaling

Shapiro, R. S., Uppuluri, P., Zaas, A. K., Collins, C., Senn, H., Perfect, J. R., Heitman, J., & Cowen, L. E. (2009) · Current Biology

Fungal and yeast genetics researchHeat shock proteins research

Cited by 311

The Deferasirox–AmBisome Therapy for Mucormycosis (DEFEAT Mucor) study: a randomized, double-blinded, placebo-controlled trial

Spellberg, B., Ibrahim, A. S., Chin-Hong, P. V., Kontoyiannis, D. P., Morris, M. I., Perfect, J. R., Fredricks, D., & Brass, E. P. (2012) · Journal of Antimicrobial Chemotherapy

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 308

Calcineurin Controls Growth, Morphology, and Pathogenicity in Aspergillus fumigatus

Steinbach, W. J., Cramer, R. A., Perfect, B. Z., Asfaw, Y. G., Sauer, T. C., Najvar, L. K., Kirkpatrick, W. R., Patterson, T. F., Benjamin, D. K., Heitman, J., et al. (2006) · Eukaryotic Cell

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 264