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Relationship of Pneumocystis Antibody Response to Severity of Chronic Obstructive Pulmonary Disease
Open accessAbstract
Pneumocystis colonization has been associated with severity of chronic obstructive pulmonary disease (COPD). The relationship of Pneumocystis antibody status to COPD severity has not been investigated, but antibody levels might relate to both colonization susceptibility and COPD progression. We investigated anti-Pneumocystis antibody titers and airway obstruction in a cohort of patients with COPD. Undetectable anti-Pneumocystis antibody titer was an independent predictor of more-severe airway obstruction, although use of inhaled corticosteroids is a possible confounder of this effect.
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Fungal infections can complicate chronic conditions and nonfungal infections, including in patients with asthma, cirrhosis, COPD, diabetes, cystic fibrosis, tuberculosis, and influenza.
“Fungal infections can further complicate chronic conditions and nonfungal infections, reported in patients with asthma [12], cirrhosis [13], chronic obstructive pulmonary disease (COPD) [14], diabetes [15, 16], cystic fibrosis (CF) [17, 18], tuberculosis [19], and influenza [20, 21].”
From Prevalence and Healthcare Burden of Fungal Infections in the United States, 2018 (2022) · cites this paper as [14]
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Metadata
- Authors
- Morris, A., Netravali, M., Kling, H. M., Shipley, T., Ross, T., Sciurba, F. C., & Norris, K. A.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Morris, Alison
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-10
- Volume
- 47
- Issue
- 7
- Pages
- e64-e68
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- PMC
- PMC2602869
- OpenAlex
- W2152858989
- Cited by
- 39
- References
- 17
- Citations by year
- 2026: 2 · 2025: 2 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2016: 2 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Clinical Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Pittsburgh
- National Institutes of Health (UL1TR000005)
- National Heart, Lung, and Blood Institute (P50HL084948, K23HL072837, HL07837, R01HL083462)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Epidemiology › Pneumocystis jirovecii pneumonia detection and treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
- Keywords
- Pneumocystis, chronic obstructive pulmonary disease, disease severity, airway obstruction, Pneumocystis colonization, antibody titers, inhaled corticosteroids
- MeSH terms
- Antibodies, Fungal, Female, Humans, Male, Middle Aged, Serine Endopeptidases, Smoking, Multivariate Analysis, Pulmonary Disease, Chronic Obstructive, Pneumocystis carinii
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