The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Immune Reconstitution Inflammatory Syndrome: A Reappraisal
Open accessAbstract
Individuals with human immunodeficiency virus infection who commence antiretroviral therapy when they are very immunodeficient are susceptible to immune reconstitution disorders. The most common disorders are the various forms of immune restoration disease (IRD) that appear to result from the restoration of a dysregulated immune response against pathogen-specific antigens. Essentially, any pathogen that can cause an opportunistic infection as a result of cellular immunodeficiency can provoke IRD when pathogen-specific immune responses recover during antiretroviral therapy. In resource-poor countries, Mycobacterium tuberculosis and Cryptococcus neoformans are the most significant pathogens, because the former causes substantial morbidity and the latter causes substantial mortality. IRD associated with these pathogens is characterized by severe inflammatory responses and is often referred to as immune reconstitution inflammatory syndrome. Prevention and treatment strategies for IRD are being developed, but preliminary data have demonstrated the efficacy of corticosteroid therapy in severe cases. Immune reconstitution after antiretroviral therapy may also be associated with autoimmune disease or sarcoidosis, both of which appear to have an immunopathogenesis that is different from that of IRD.
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Iannuzzi, M. C., Rybicki, B. A., & Teirstein, A. S. (2007) · New England Journal of Medicine · doi:10.1056/nejmra071714 · Cited by 1,968
Meintjes, G., Lawn, S. D., Scano, F., Maartens, G., French, M. A., Worodria, W., Elliott, J. H., Murdoch, D., Wilkinson, R. J., Seyler, C., et al. (2008) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(08)70184-1 · Cited by 745
Self-citationSHELBURNE, S. A., HAMILL, R. J., RODRIGUEZ-BARRADAS, M. C., GREENBERG, S. B., ATMAR, R. L., MUSHER, D. M., GATHE, J. C., VISNEGARWALA, F., & TRAUTNER, B. W. (2002) · Medicine · doi:10.1097/00005792-200205000-00005 · Cited by 654
Immune restoration disease after antiretroviral therapy
French, M. A., Price, P., & Stone, S. F. (2004) · AIDS · doi:10.1097/01.aids.0000131375.21070.06 · Cited by 651
Self-citationKamradt, T., & Mitchison, N. A. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103013440907 · Cited by 457
French, M. A., Lenzo, N., John, M., Mallal, S. A., McKinnon, E. J., James, I. R., Price, P., Flexman, J. P., & Tay‐Kearney, M. (2000) · HIV Medicine · doi:10.1046/j.1468-1293.2000.00012.x · Cited by 413
Self-citationScriba, T. J., Kalsdorf, B., Abrahams, D.-A., Isaacs, F., Hofmeister, J., Black, G., Hassan, H. Y., Wilkinson, R. J., Walzl, G., Gelderbloem, S. J., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1962 · Cited by 410
Lawn, S. D., Myer, L., Bekker, L.-G., & Wood, R. (2007) · AIDS · doi:10.1097/qad.0b013e328011efac · Cited by 343
Lortholary, O., Fontanet, A., Mémain, N., Martin, A., Sitbon, K., & Dromer, F. (2005) · AIDS · doi:10.1097/01.aids.0000174450.70874.30 · Cited by 324
Cited by
HIV and Tuberculosis: a Deadly Human Syndemic
Kwan, C. K., & Ernst, J. D. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00042-10 · Cited by 720
Maziarz, E. K., & Perfect, J. R. (2016) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2015.10.006 · Cited by 698
Secondary immunodeficiencies, including HIV infection
Chinen, J., & Shearer, W. T. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.08.040 · Cited by 305
Cryptococcal meningitis: epidemiology and therapeutic options
Sloan, D., & Parris, V. (2014) · Clinical Epidemiology · doi:10.2147/clep.s38850 · Cited by 277
Immune reconstitution inflammatory syndrome: the trouble with immunity when you had none
Barber, D. L., Andrade, B. B., Sereti, I., & Sher, A. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2712 · Cited by 169
Metadata
- Authors
- French, M. A.
- Venue
- Clinical Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01
- Volume
- 48
- Issue
- 1
- Pages
- 101-107
- ISSN
- 1058-4838 (ISSN-L)
- 1537-6591
- OpenAlex
- W2106841078
- Cited by
- 323
- References
- 49
- FWCI
- 33.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
