The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Incidence and risk factors of immune reconstitution inflammatory syndrome complicating HIV-associated cryptococcosis in France
Abstract
BACKGROUND: Immune reconstitution inflammatory syndrome (IRIS) in association with cryptococcosis has been anecdotically reported following administration of highly active antiretroviral therapy (HAART). OBJECTIVE: To analyse the incidence and risk factors for IRIS-associated cryptococcosis among HIV-infected patients. DESIGN: Retrospective multicentre study between 1996 and 2000 through the French Cryptococcosis Database. METHODS: Subsequent occurrence of IRIS examined in 120 HIV-infected adult patients treated with HAART and experiencing a first episode of culture-confirmed cryptococcosis. RESULTS: Ten patients developed IRIS during the study period, giving an incidence of 10/239, or 4.2/100 person-years [95% confidence interval (CI), 2.2-7.8]. IRIS consisted of acute symptoms consistent with inflammation occurring within a median of 8 months (range, 2-37) after the diagnosis of cryptococcosis in the context of negative cultures and immunological and/or virological response to HAART. Radiology and histopathology detected features compatible with inflammation. Symptom severity required transfer into intensive care units for three patients and use of anti-inflammatory drugs for four. Three patients with evolutive IRIS died. Compared with patients without IRIS for whom complete clinical and microbiological information were available at baseline, previously unknown HIV infection [odds ratio (OR), 4.8; 95% CI, 1.0-21.7], CD4 cell count < 7 x 10 cells/l (OR, 4.0; 95% CI, 0.9-17.2), fungaemia (OR, 6.1; 95% CI, 1.1-35.2) and HAART initiation within 2 months of cryptococcosis diagnosis (OR, 5.50; 95% CI, 1.0-29.6) were independently associated with the risk of subsequent IRIS. CONCLUSIONS: IRIS-related cryptococcosis was observed more frequently in severely immunocompromised patients with disseminated infection and HAART initiation soon after the diagnosis.
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SHELBURNE, S. A., HAMILL, R. J., RODRIGUEZ-BARRADAS, M. C., GREENBERG, S. B., ATMAR, R. L., MUSHER, D. M., GATHE, J. C., VISNEGARWALA, F., & TRAUTNER, B. W. (2002) · Medicine · doi:10.1097/00005792-200205000-00005 · Cited by 654
Paradoxical Worsening of Tuberculosis Following Antiretroviral Therapy in Patients with AIDS
NARITA, M., ASHKIN, D., HOLLENDER, E. S., & PITCHENIK, A. E. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.1.9712001 · Cited by 608
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Immune Reconstitution in HIV‐Infected Patients
Hirsch, H. H., Kaufmann, G., Sendi, P., & Battegay, M. (2004) · Clinical Infectious Diseases · doi:10.1086/383034 · Cited by 327
Epidemiology of Cryptococcosis in France: A 9-Year Survey (1985-1993)
Dromer, F., Mathoulin, S., Dupont, B., Laporte, A., & French Cryptococcosis Study Group (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/23.1.82 · Cited by 240
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Cited by
Perfect, J. R., Dismukes, W. E., Dromer, F., Goldman, D. L., Graybill, J. R., Hamill, R. J., Harrison, T. S., Larsen, R. A., Lortholary, O., Nguyen, M.-H., et al. (2010) · Clinical Infectious Diseases · doi:10.1086/649858 · Cited by 2,660
Self-citationMaziarz, E. K., & Perfect, J. R. (2016) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2015.10.006 · Cited by 698
Early mortality among adults accessing antiretroviral treatment programmes in sub-Saharan Africa
Lawn, S. D., Harries, A. D., Anglaret, X., Myer, L., & Wood, R. (2008) · AIDS · doi:10.1097/qad.0b013e32830007cd · Cited by 639
Evidence of a Role for Monocytes in Dissemination and Brain Invasion by Cryptococcus neoformans
Charlier, C., Nielsen, K., Daou, S., Brigitte, M., Chretien, F., & Dromer, F. (2009) · Infection and Immunity · doi:10.1128/iai.01065-08 · Cited by 362
Self-citationImmune Reconstitution Inflammatory Syndrome: A Reappraisal
French, M. A. (2009) · Clinical Infectious Diseases · doi:10.1086/595006 · Cited by 323
Metadata
- Authors
- Lortholary, O., Fontanet, A., Mémain, N., Martin, A., Sitbon, K., & Dromer, F.
- Venue
- AIDS
- Published
- 2005-07-01
- Volume
- 19
- Issue
- 10
- Pages
- 1043-1049
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W1963966543
- Cited by
- 324
- References
- 27
- FWCI
- 16.36
- Type
- journal article
- Language
- en
- Open access
- closed
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