The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral‐Treated HIV Infection
Open accessAbstract
The significance of elevated plasma levels of bacterial lipopolysaccharide (LPS) in persons with chronic HIV infection remains undefined. We measured LPS levels by use of limulus lysate assay, and DNA sequences encoding bacterial ribosomal 16S RNA (16S rDNA) were assessed by quantitative polymerase chain reactions in plasma samples obtained from 242 donors. Plasma levels of 16S rDNA were significantly higher in human immunodeficiency virus (HIV)-infected subjects than in uninfected subjects, and they correlated with LPS levels. Higher levels of 16S rDNA were associated with higher levels of T cell activation and with lower levels of CD4 T cell restoration during antiretroviral therapy. Antiretroviral therapy reduces but does not fully normalize plasma levels of bacterial 16S rDNA, an index of microbial translocation from the gastrointestinal tract. High levels of 16S rDNA during therapy are strongly associated with reduced increases in the CD4(+) T lymphocyte count, irrespective of plasma HIV RNA levels. These findings are consistent with the importance of microbial translocation in immunodeficiency and T cell homeostasis in chronic HIV infection.
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Cites
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559
Self-citationChanges in thymic function with age and during the treatment of HIV infection
Douek, D. C., McFarland, R. D., Keiser, P. H., Gage, E. A., Massey, J. M., Haynes, B. F., Polis, M. A., Haase, A. T., Feinberg, M. B., Sullivan#, J. L., et al. (1998) · Nature · doi:10.1038/25374 · Cited by 1,893
Self-citationHIV preferentially infects HIV-specific CD4+ T cells
Douek, D. C., Brenchley, J. M., Betts, M. R., Ambrozak, D. R., Hill, B. J., Okamoto, Y., Casazza, J. P., Kuruppu, J., Kunstman, K., Wolinsky, S., et al. (2002) · Nature · doi:10.1038/417095a · Cited by 1,262
Self-citationBrenchley, J. M., Karandikar, N. J., Betts, M. R., Ambrozak, D. R., Hill, B. J., Crotty, L. E., Casazza, J. P., Kuruppu, J., Migueles, S. A., Connors, M., et al. (2003) · Blood · doi:10.1182/blood-2002-07-2103 · Cited by 1,073
Self-citationGiorgi, J. V., Hultin, L. E., McKeating, J. A., Johnson, T. D., Owens, B., Jacobson, L. P., Shih, R., Lewis, J., Wiley, D. J., Phair, J. P., et al. (1999) · The Journal of Infectious Diseases · doi:10.1086/314660 · Cited by 1,033
Hunt, P. W., Martin, J. N., Sinclair, E., Bredt, B., Hagos, E., Lampiris, H., & Deeks, S. G. (2003) · The Journal of Infectious Diseases · doi:10.1086/374786 · Cited by 852
Self-citationPakker, N. G., Notermans, D. W., De Boer, R. J., Roos, M. T. L., Wolf, F. D., Hill, A., Leonard, J. M., Danner, S. A., Miedema, F., & Schellekens, P. T. A. (1998) · Nature Medicine · doi:10.1038/nm0298-208 · Cited by 701
Hunt, P. W., Brenchley, J., Sinclair, E., McCune, J. M., Roland, M., Page‐Shafer, K., Hsue, P., Emu, B., Krone, M., Lampiris, H., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/524143 · Cited by 638
Self-citationThe dynamics of CD4+ T-cell depletion in HIV disease
McCune, J. M. (2001) · Nature · doi:10.1038/35073648 · Cited by 583
HIV disease: fallout from a mucosal catastrophe?
Brenchley, J. M., Price, D. A., & Douek, D. C. (2006) · Nature Immunology · doi:10.1038/ni1316 · Cited by 579
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Self-citationSystemic Effects of Inflammation on Health during Chronic HIV Infection
Deeks, S. G., Tracy, R., & Douek, D. C. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.001 · Cited by 868
Self-citationNational Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2
Jacobson, T. A., Maki, K. C., Orringer, C. E., Jones, P. H., Kris-Etherton, P., Sikand, G., La Forge, R., Daniels, S. R., Wilson, D. P., Morris, P. B., et al. (2015) · Journal of Clinical Lipidology · doi:10.1016/j.jacl.2015.09.002 · Cited by 784
The impoverished gut—a triple burden of diarrhoea, stunting and chronic disease
Guerrant, R. L., DeBoer, M. D., Moore, S. R., Scharf, R. J., & Lima, A. A. M. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.239 · Cited by 604
Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concepts
Trinchieri, G. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075008 · Cited by 511
Metadata
- Authors
- Jiang, W., Lederman, M. M., Hunt, P., Sieg, S. F., Haley, K., Rodriguez, B., Landay, A., Martin, J., Sinclair, E., Asher, A. I., Deeks, S. G., Douek, D. C., & Brenchley, J. M.
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-04-15
- Volume
- 199
- Issue
- 8
- Pages
- 1177-1185
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2130603879
- Cited by
- 591
- References
- 31
- FWCI
- 19.65
- Type
- journal article
- Language
- en
- Open access
- green
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- Jiang, W., Lederman, M. M., Hunt, P., Sieg, S. F., Haley, K., Rodriguez, B., Landay, A., Martin, J., Sinclair, E., Asher, A. I., Deeks, S. G., Douek, D. C., & Brenchley, J. M. (2009). Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral‐Treated HIV Infection. The Journal of Infectious Diseases. https://doi.org/10.1086/597476
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
